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Full-Text Articles in Social and Behavioral Sciences
Comments On Slee Et Al. (2012). A Reassessment Of Last Interglacial Deposits At Mary Ann Bay, Tasmania. Quaternary Australasia 29: 4-11, Colin V. Murray-Wallace, Eric A. Colhoun, Albert Goede, Patrick G. Quilty
Comments On Slee Et Al. (2012). A Reassessment Of Last Interglacial Deposits At Mary Ann Bay, Tasmania. Quaternary Australasia 29: 4-11, Colin V. Murray-Wallace, Eric A. Colhoun, Albert Goede, Patrick G. Quilty
Faculty of Science, Medicine and Health - Papers: part A
It is always pleasing to see additional work undertaken on sedimentary successions that are critical to the understanding of Quaternary environmental changes. The deposits at Mary Ann Bay, as with other last interglacial (MIS 5e; 128-118 ka) coastal-marine successions in Tasmania, are critical for demonstrating that the region has experienced a different relative sea-level history to mainland southeastern Australia, and that parts of Tasmania have been uplifted by 16-17 m since the last interglacial maximum. Unfortunately, the recently published paper by Slee et al. (2012) gives credence to two thermoluminescence (TL) ages which must be inaccurate. In uncritically accepting the …
Elevated Stearoyl-Coa Desaturase In Brains Of Patients With Alzheimer's Disease, Giuseppe Astarita, Kwang-Mook Jung, Vitaly Vasilevko, Nicholas V. Dipatrizio, Sarah K. Martin, David H. Cribbs, Elizabeth Head, Carl W. Cotman, Daniele Piomelli
Elevated Stearoyl-Coa Desaturase In Brains Of Patients With Alzheimer's Disease, Giuseppe Astarita, Kwang-Mook Jung, Vitaly Vasilevko, Nicholas V. Dipatrizio, Sarah K. Martin, David H. Cribbs, Elizabeth Head, Carl W. Cotman, Daniele Piomelli
Sanders-Brown Center on Aging Faculty Publications
The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls (N = 17). The analyses revealed statistically detectable elevations in levels of non-esterified monounsaturated fatty acids (MUFAs) and mead acid (20:3n-9) in mid-frontal cortex, temporal cortex and hippocampus of AD patients. Further studies showed that brain mRNAs encoding for isoforms of the rate-limiting enzyme in MUFAs biosynthesis, stearoyl-CoA desaturase (SCD-1, SCD-5a and SCD-5b), were elevated in subjects with AD. The monounsaturated/saturated fatty acid ratio ('desaturation index')--displayed a strong …