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Effects Of Mp2rage B1+ Sensitivity On Inter-Site T1 Reproducibility And Hippocampal Morphometry At 7t, Roy A.M. Haast, Jonathan C. Lau, Dimo Ivanov, Ravi S. Menon, Kâmil Uludağ, Ali R. Khan

Brain and Mind Institute Researchers' Publications

Most neuroanatomical studies are based on T -weighted MR images, whose intensity profiles are not solely determined by the tissue's longitudinal relaxation times (T ), but also affected by varying non-T contributions, hampering data reproducibility. In contrast, quantitative imaging using the MP2RAGE sequence, for example, allows direct characterization of the brain based on the tissue property of interest. Combined with 7 Tesla (7T) MRI, this offers unique opportunities to obtain robust high-resolution brain data characterized by a high reproducibility, sensitivity and specificity. However, specific MP2RAGE parameter choices – e.g., to emphasize intracortical myelin-dependent contrast variations – can substantially impact image …