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Full-Text Articles in Social and Behavioral Sciences
Generation Of Hydrogen Peroxide-Resistant Murine Neuroblastoma Cells: A Target Discovery Platform For Novel Neuroprotective Genes, Annette E. Maczurek, Rebekka Wild, Daunia Laurenti, Megan L. Steele, Lezanne Ooi, Gerald Munch
Generation Of Hydrogen Peroxide-Resistant Murine Neuroblastoma Cells: A Target Discovery Platform For Novel Neuroprotective Genes, Annette E. Maczurek, Rebekka Wild, Daunia Laurenti, Megan L. Steele, Lezanne Ooi, Gerald Munch
Faculty of Science, Medicine and Health - Papers: part A
Oxidative stress has been suggested to play an important role in the pathogenesis of various neurodegenerative diseases including Alzheimer’s disease (AD). Hydrogen peroxide (H2O2), one of the main reactive oxygen species, is converted into the highly toxic ·OH radical in the presence of redox-active transition metals, which then oxidises nucleic acids, lipids and proteins, leading to neurodegeneration and cell death. There is an urgent need to gain more knowledge about relevant therapeutic targets to combat oxidative stress and it neurotoxic effects, and how this knowledge can be utilized to develop novel neuroprotective therapies for AD. One way to identify new …
Structure Based Design Towards The Identification Of Novel Binding Sites And Inhibitors For The Chikungunya Virus Envelope Proteins, Adel A. Rashad, Paul A. Keller
Structure Based Design Towards The Identification Of Novel Binding Sites And Inhibitors For The Chikungunya Virus Envelope Proteins, Adel A. Rashad, Paul A. Keller
Faculty of Science, Medicine and Health - Papers: part A
Chikungunya virus is an emerging arbovirus that is widespread in tropical regions and is spreading quickly to temperate climates with recent epidemics in Africa, Asia, Europe and the Americas. It is having an increasingly major impact on humans with potentially life-threatening and debilitating arthritis. Thus far, neither vaccines nor medications are available to treat or control the virus and therefore, the development of medicinal chemistry is a vital and immediate issue that needs to be addressed. The viral envelope proteins play a major role during infection through mediation of binding and fusion with the infected cell surfaces. The possible binding …
6-Hydroxy-5,6-Seco-Stemocurtisine: A Novel Seco-Stemocurtisine-Type Alkaloid, Pitchaya Mungkornasawakul, Stephen G. Pyne, Anthony C. Willis, Araya Jatisatienr, Duang Phuthsuk, Wilford Lie
6-Hydroxy-5,6-Seco-Stemocurtisine: A Novel Seco-Stemocurtisine-Type Alkaloid, Pitchaya Mungkornasawakul, Stephen G. Pyne, Anthony C. Willis, Araya Jatisatienr, Duang Phuthsuk, Wilford Lie
Faculty of Science, Medicine and Health - Papers: part A
A novel seco-stemocurtisine-type alkaloid, 6-hydroxy-5,6-seco-stemocurtisine was isolated from the aerial parts of Stemona curtisii (Stemonaceae) collected from Trang Province in Thailand. The unprecedented 5,6-seco-pyrido[1,2-a] azepine structure was elucidated by 2D NMR analysis and a single crystal X-ray crystallographic analysis. (C) 2013 Phytochemical Society of Europe.