Social and Behavioral Sciences Commons^™

Four Potential Criteria For Deciding When To Use Antidepressants Or Psychotherapy For Unipolar Depression: A Literature Review, Christopher Sharpley, Vicki Bitsika

Vicki Bitsika

Objective: To evaluate the literature supporting four potential criteria for deciding whether to use psychotherapy or pharmacology when treating depression.

Method: Literature review of the evidence from the last 10 years on presenting patient’s demographics, aetiology, comorbidity, and genetic factors, as predictors of treatment outcome efficacy.

Results: Demographic information has little support as a potential criteria for decision-making; aetiology (melancholic vs. non-melancholic) has significant support; presence of personality disorder comorbidity is unproven as a criterion but may have some value; genetic predisposition has the strongest evidence supporting it as a criteria for treatment decision-making.

Conclusion: Although some presenting cases will …