Social and Behavioral Sciences Commons^™

Self-Reported Racism, Transphobia, Their Intersection And Impact On Past-Year Hiv Related Sexual Risk Behaviour, Roxanne M. Longman Marcellin

Electronic Thesis and Dissertation Repository

Background: Studies examining HIV prevalence and risk behaviors within trans subgroups have identified them as high risk. Yet few studies have addressed how discrimination impacts this prevalence. Minority stress theory suggests that there is a relationship between minority stress and HIV-related risk behaviour. We hypothesize that multiple minority statuses may result in discriminatory experiences, specifically self-reported transphobia and racism in synchrony with other attributes, that interact to alter past-year HIV-related risk behaviour.

Methods: Data came from the Trans PULSE project, a mixed-methods, community-based research study that used respondent-driven sampling to access 433 trans Ontarians, between May 2009 and …

The Cost-Effectiveness Of Combination Treatment Consisting Of Either Cetuximab Or Panitumumab Plus Folfiri Versus Treatment With Bevacizumab Plus Folfiri As First-Line Treatment For Kras Wild-Type Metastatic Colorectal Cancer Patients In Ontario, Emmanuel M.G. Ewara

Electronic Thesis and Dissertation Repository

I conducted a cost-effectiveness analysis of combination cetuximbab or panitumumab plus FOLFIRI as first-line treatment for patients with metastatic colorectal cancer (MCRC) from the perspective of the Ontario healthcare payer. I developed a Markov decision analytical model to simulate the lifetime costs and benefits of each treatment option. The model was parameterized using data collected from administrative databases in the province of Ontario and from published clinical trials. In the base case scenario, treatment consisting of bevacizumab plus FOLFIRI was found to dominate other treatment options. The ICER values were found to be sensitive to the efficacy of first-line treatment, …

Algorithmic Decomposition Of Shuffle On Words, Franziska Biegler, Mark Daley, Ian Mcquillan

Brain and Mind Institute Researchers' Publications

We investigate shuffle-decomposability into two words. We give an algorithm which takes as input a DFA M (under certain conditions) and determines the unique candidate decomposition into words u and v such that L(M) = u v ifM is shuffle decomposable, in time O(|u| + |v|). Even though this algorithm does not determine whether or not the DFA is shuffle decomposable, the sublinear time complexity of only determining the two words under the assumption of decomposability is surprising given the complexity of shuffle, and demonstrates an interesting property of the operation. We also show that for given words u and …

Expanding The Basic Science Debate: The Role Of Physics Knowledge In Interpreting Clinical Findings., Mark Goldszmidt, John Paul Minda, Sarah L Devantier, Aimee L Skye, Nicole N Woods

Brain and Mind Institute Researchers' Publications

Current research suggests a role for biomedical knowledge in learning and retaining concepts related to medical diagnosis. However, learning may be influenced by other, non-biomedical knowledge. We explored this idea using an experimental design and examined the effects of causal knowledge on the learning, retention, and interpretation of medical information. Participants studied a handout about several respiratory disorders and how to interpret respiratory exam findings. The control group received the information in standard "textbook" format and the experimental group was presented with the same information as well as a causal explanation about how sound travels through lungs in both the …

Psychophysical And Neural Evidence For Emotion-Enhanced Perceptual Vividness, Rebecca M. Todd, Deborah Talmi, Taylor W. Schmitz, Josh Susskind, Adam K. Anderson

Brain and Mind Institute Researchers' Publications

Highly emotional events are associated with vivid "flashbulb" memories. Here we examine whether the flashbulb metaphor characterizes a previously unknown emotion-enhanced vividness (EEV) during initial perceptual experience. Using a magnitude estimation procedure, human observers estimated the relative magnitude of visual noise overlaid on scenes. After controlling for computational metrics of objective visual salience, emotional salience was associated with decreased noise, or heightened perceptual vividness, demonstrating EEV, which predicted later memory vividness. Event-related potentials revealed a posterior P2 component at ~200 ms that was associated with both increased emotional salience and decreased objective noise levels, consistent with EEV. Blood oxygenation level-dependent …

Perceptual Fluency Can Be Used As A Cue For Categorization Decisions., Sarah J Miles, John Paul Minda

Brain and Mind Institute Researchers' Publications

Learning in the prototype distortion task is thought to involve perceptual learning in which category members experience an enhanced visual response (Ashby & Maddox. Annual Review of Psychology, 56, 149-178, 2005). This response likely leads to more-efficient processing, which in turn may result in a feeling of perceptual fluency for category members. We examined the perceptual-fluency hypothesis by manipulating fluency independently from category membership. We predicted that when perceptual fluency was induced using subliminal priming, this fluency would be misattributed to category membership and would affect categorization decisions. In a prototype distortion task, the participants were more likely to judge …

Gonadotropin-Releasing Hormone Plasticity: A Comparative Perspective., T J Stevenson, T P Hahn, S A Macdougall-Shackleton, G F Ball

Brain and Mind Institute Researchers' Publications

Gonadotropin-releasing hormone 1 (GnRH1) is a key regulator of the reproductive neuroendocrine system in vertebrates. Recent developments have suggested that GnRH1 neurons exhibit far greater plasticity at the cellular and molecular levels than previously thought. Furthermore, there is growing evidence that sub-populations of GnRH1 neurons in the preoptic area are highly responsive to specific environmental and hormonal conditions. In this paper we discuss findings that reveal large variation in GnRH1 mRNA and protein expression that are regulated by social cues, photoperiod, and hormonal feedback. We draw upon studies using histochemistry and immediate early genes (e.g., c-FOS/ZENK) to illustrate that specific …

“We Should Be Listening To Our Elders”: Evaluation Of Transfer Of Indigenous Knowledge Between Anishinabe Youth And Elders, Kassandra Kulmann

Electronic Thesis and Dissertation Repository

Indigenous knowledge (IK) (knowledge held by Indigenous peoples regarding local environments, ways of life and culture) can potentially improve health and environment conditions. This thesis examines IK transfer between Anishinabe Elders and youth. A knowledge translation intervention was applied to address community concerns regarding decline of IK transfer between Elders and youth.

Youth were hired to participate in a summer school and interview Elders regarding environment and health issues. Qualitative interviews were conducted with youth before and after their internships to evaluate their experiences and IK uptake. The summer school and internships were effective for facilitating IK transfer between Elders …

How Do Parents Use Health Information With The Aid Of A Knowledge Broker When Living With And Caring For Their Young Children With Cerebral Palsy?, Stephanie E. Lagosky

Electronic Thesis and Dissertation Repository

This research aims to understand how parents use health information (such as those developed from the Move & PLAY study) with the aid of a knowledge broker when living with and caring for young children with cerebral palsy. This research was conducted under a qualitative case study methodology and used questionnaires and in-depth interviews to collect data. Findings include the complexity of both parental use of health information and the desire to use a knowledge broker. A provisional model has been created to help describe information use of parents with young children with cerebral palsy. This provisional model is an …

Intimate Partner Violence (Ipv) And The Social Determinants Of Aboriginal Peoples’ Health: A Case Study Of First Nations Women’S Resilience, Resistance, And Renewal, Julie A. George

Electronic Thesis and Dissertation Repository

Worldwide, First Nations women are among the most vulnerable to Intimate Partner Violence (IPV); and yet, their lived experiences of violence are lacking in the literature. Using Photovoice methodology and a community-based, participatory action approach, this project addresses multiple questions pertaining to First Nations mothers’ experiences of IPV, including: What are the health and social consequences of IPV and how do the social determinants of Aboriginal peoples’ health shape the capacities of women survivors to manage and overcome IPV? Drawing on decolonization theory, a social determinants of Aboriginal peoples’ health framework, and aspects of feminist theory, this project was designed …

Enacting Occupation And Identity: Perspectives Of Children And Their Parents, Shanon K. Phelan

Electronic Thesis and Dissertation Repository

Children with disabilities are at risk for limited opportunities to engage in childhood occupations. Occupation is defined broadly as everything people need, want, or are obliged to do, and as understanding how social dimensions shape occupations and opportunities for participation. Emergent literature suggests that identities are shaped by what we do. This research examines how occupation is implicated in the shaping of identities for school-aged children with physical disabilities in light of the socio-cultural dimensions that shape opportunities for children to participate in childhood occupations.

This work is comprised of five integrated manuscripts, in addition to introduction, methodology, and …

Preliminary Economic Evaluation Of Brentuximab Vedotin In Relapsed And Refractory Hodgkin Lymphoma: An "Early Look" Model Based On Phase Ii Results, Vusal Babashov

Electronic Thesis and Dissertation Repository

We conducted a cost-effectiveness analysis of brentuximab vedotin for the treatment of relapsed and refractory Hodgkin Lymphoma (HL) from health care system perspective in Canada. We developed a Markov decision analytical model to simulate lifetime costs and benefits and parameterized the model using brentuximab phase II clinical trial and cd-link data which is a linked datasets of cancer registry with administrative databases of Ontario, Canada. In the base case scenario, brentuximab treatment led to an increase of 0.352 Quality Adjusted Life Years (QALYs) per person and $108,500 per person, which resulted in incremental cost effectiveness ratio (ICER) of $308,532 per …

Suicide In Young Men, Alexandra Pitman, Karolina Krysinska, Michael King

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.

Resting-State Connectivity Identifies Distinct Functional Networks In Macaque Cingulate Cortex., R Matthew Hutchison, Thilo Womelsdorf, Joseph S Gati, L Stan Leung, Ravi S Menon, Stefan Everling

Brain and Mind Institute Researchers' Publications

Subregions of the cingulate cortex represent prominent intersections in the structural networks of the primate brain. The relevance of the cingulate to the structure and dynamics of large-scale networks ultimately requires a link to functional connectivity. Here, we map fine-grained functional connectivity across the complete extent of the macaque (Macaca fascicularis) cingulate cortex and delineate subdivisions pertaining to distinct identifiable networks. In particular, we identified 4 primary networks representing the functional spectrum of the cingulate: somatomotor, attention-orienting, executive, and limbic. The cingulate nodes of these networks originated from separable subfields along the rostral-to-caudal axis and were characterized by positive and …

Greater Benefits Of Multisensory Integration During Complex Sensorimotor Transformations., Verena N Buchholz, Samanthi C Goonetilleke, W Pieter Medendorp, Brian D Corneil

Brain and Mind Institute Researchers' Publications

Multisensory integration enables rapid and accurate behavior. To orient in space, sensory information registered initially in different reference frames has to be integrated with the current postural information to produce an appropriate motor response. In some postures, multisensory integration requires convergence of sensory evidence across hemispheres, which would presumably lessen or hinder integration. Here, we examined orienting gaze shifts in humans to visual, tactile, or visuotactile stimuli when the hands were either in a default uncrossed posture or a crossed posture requiring convergence across hemispheres. Surprisingly, we observed the greatest benefits of multisensory integration in the crossed posture, as indexed …

Self-Presentation And Social Physique Anxiety In Injury Rehabilitation Settings, Molly Driediger

Electronic Thesis and Dissertation Repository

The objective of this dissertation was to provide an initial description of self-presentation in injury rehabilitation (i.e., physiotherapy). To accomplish this, one qualitative and two quantitative studies were conducted. Study 1 determined whether self-presentational concerns were present in this setting. Female (n = 134) and male (n = 54) undergraduate students with a mean age of 20.64 years (SD = 1.99) completed measures of Social Physique Anxiety (SPA; Hart et al., 1989), self-presentational concerns, and preferences for features of the social and physical physiotherapy environment. An examination of the relationships between these variables revealed that self-presentation exists …

Hearts And Minds: Examining The Evolution Of The Egyptian Excerebration And Evisceration Traditions Through The Impact Mummy Database, Andrew D. Wade

Electronic Thesis and Dissertation Repository

Egyptian mummification and funerary rituals were a transformative process, making the deceased a pure being; free of disease, injury, and disfigurements, as well as ethical and moral impurities. Consequently, the features of mummification available to specific categories of individuals hold social and ideological significance. This study refutes long-held classical stereotypes, particularly dogmatic class associations; demonstrates the apocryphal nature of universal heart retention; and expands on the purposes of excerebration and evisceration implied by synthetic and radiological analyses.

Features of the embalming traditions, specifically the variable excerebration and evisceration traditions, represented the Egyptian view of death. Fine-grain analyses, through primary imaging …

Encoding Of Sensory Prediction Errors In The Human Cerebellum., John Schlerf, Richard B Ivry, Jörn Diedrichsen

Brain and Mind Institute Researchers' Publications

A central tenet of motor neuroscience is that the cerebellum learns from sensory prediction errors. Surprisingly, neuroimaging studies have not revealed definitive signatures of error processing in the cerebellum. Furthermore, neurophysiologic studies suggest an asymmetry, such that the cerebellum may encode errors arising from unexpected sensory events, but not errors reflecting the omission of expected stimuli. We conducted an imaging study to compare the cerebellar response to these two types of errors. Participants made fast out-and-back reaching movements, aiming either for an object that delivered a force pulse if intersected or for a gap between two objects, either of which …

Provision Of Pandemic Disease Information By Health Sciences Librarians: A Multisite Comparative Case Series., Robin Featherstone, Gabriel Boldt, Nazi Torabi, Shauna-Lee Konrad

Western Libraries Publications

Objective: The research provides an understanding of pandemic information needs and informs professional development initiatives for librarians in disaster medicine. Methods: Utilizing a multisite, comparative case series design, the researchers conducted semi-structured interviews and examined supplementary materials in the form of organizational documents, correspondence, and websites to create a complete picture of each case. The rigor of the case series was ensured through data and investigator triangulation. Interview transcripts were coded using NVivo to identify common themes and points of comparison. Results: Comparison of the four cases revealed a distinct difference between “client-initiated” and “librarian-initiated” provision of pandemic information. Librarian-initiated …

Does Access To A Family Physician Matter For Adolescents?, Bridget L. Ryan, Moira Stewart, M. Karen Campbell, John Koval, Amardeep Thind

RDC@Western Research Highlights

No abstract provided.

Does Access To A Family Physician Matter For Adolescents?, Bridget L. Ryan, Moira Stewart, M. Karen Campbell, John J. Koval, Amardeep Thind

CRDCN Research Highlight/RCCDR en évidence

No abstract provided.

Preventing Mental Distress In The Military, Charles Nelson, Kate St. Cyr, Bradley Corbett, Elisa Hurley, Shannon Gifford, Jon D. Elhaid, J. Donald Richardson

RDC@Western Research Highlights

No abstract provided.

Preventing Mental Distress In The Military, Charles Nelson, Kate St. Cyr, Bradley Corbett, Elisa Hurley, Shannon Gifford, Jon D. Elhai, J. Donald Richardson

CRDCN Research Highlight/RCCDR en évidence

No abstract provided.

Discriminating Famous From Fictional Names Based On Lifetime Experience: Evidence In Support Of A Signal-Detection Model Based On Finite Mixture Distributions., Ben Bowles, Iain M Harlow, Melissa M Meeking, Stefan Köhler

Brain and Mind Institute Researchers' Publications

It is widely accepted that signal-detection mechanisms contribute to item-recognition memory decisions that involve discriminations between targets and lures based on a controlled laboratory study episode. Here, the authors employed mathematical modeling of receiver operating characteristics (ROC) to determine whether and how a signal-detection mechanism contributes to discriminations between moderately famous and fictional names based on lifetime experience. Unique to fame judgments is a lack of control over participants' previous exposure to the stimuli deemed "targets" by the experimenter; specifically, if they pertain to moderately famous individuals, participants may have had no prior exposure to a substantial proportion of the …

Distinct Patterns Of Functional And Effective Connectivity Between Perirhinal Cortex And Other Cortical Regions In Recognition Memory And Perceptual Discrimination., Edward B O'Neil, Andrea B Protzner, Cornelia Mccormick, D Adam Mclean, Jordan Poppenk, Anthony D Cate, Stefan Köhler

Brain and Mind Institute Researchers' Publications

Traditionally, the medial temporal lobe (MTL) is thought to be dedicated to declarative memory. Recent evidence challenges this view, suggesting that perirhinal cortex (PrC), which interfaces the MTL with the ventral visual pathway, supports highly integrated object representations in recognition memory and perceptual discrimination. Even with comparable representational demands, perceptual and memory tasks differ in numerous task demands and the subjective experience they evoke. Here, we tested whether such differences are reflected in distinct patterns of connectivity between PrC and other cortical regions, including differential involvement of prefrontal control processes. We examined functional magnetic resonance imaging data for closely matched …

Area-Based Differentials In Childhood Cancer Incidence In Australia, 1996–2006, Danny R. Youlden, Peter D. Baade, Patricia C. Valery, Timothy E. Hassall, Leisa J. Ward, Adele C. Green, Joanne F. Aitken

Aboriginal Policy Research Consortium International (APRCi)

Background. International studies examining the association between the incidence of childhood cancer and characteristics of the area in which the patient lives have generally reported inconsistent patterns. Area-based differentials in childhood cancer throughout Australia have not been previously published at a national level. Procedure. Population-based information from the Australian Paediatric Cancer Registry was used to identify all children aged 0- to 14-years old diagnosed with invasive cancer or intracranial and intraspinal tumors of benign or uncertain behavior between 1996 and 2006. Age-standardized incidence rates per million children per year and the corresponding incidence rate ratios were calculated, categorized by remoteness …

Evaluation Of A Culturally Adapted Training In Indigenous Mental Health And Wellbeing For The Alcohol And Other Drug Workforce, Racheal Hinton, Tricia Nagel

Aboriginal Policy Research Consortium International (APRCi)

Indigenous Australians have high rates of mental illness comorbid with substance misuse. The complex needs of this client group create challenges for the alcohol and other drug (AOD) workforce. This paper describes the outcomes of an Indigenous-specific “Yarning about Mental Health” training for the AOD workforce to strengthen knowledge and skills in mental health approaches and in their engagement with Indigenous clients. The training provides culturally adapted strategies and tools for understanding mental health, promoting wellbeing, and delivering brief interventions in the substance misuse setting. A nonexperimental evaluation which incorporated pre-post questionnaires was conducted with workshop participants attending one of …

Growing Up Our Way : The First Year Of Life In Remote Aboriginal Australia, Sue Kruske, Suzanne Belton, Molly Wardaguga, Conceptual Narjic

Aboriginal Policy Research Consortium International (APRCi)

In this study, we attempted to explore the experiences and beliefs of Aboriginal families as they cared for their children in the first year of life. We collected family stories concerning child rearing, development, behavior, health, and wellbeing between each infant’s birth and first birthday. We found significant differences in parenting behaviors and childrearing practices between Aboriginal groups and mainstream Australians. Aboriginal parents perceived their children to be autonomous individuals with responsibilities toward a large family group. The children were active agents in determining their own needs, highly prized, and included in all aspects of community life. Concurrent with poverty, …

Children And Adolescent Exposure To Alcohol Advertising During Bathurst 1000, Sondra L. Davoren, Craig A. Sinclair

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.

Do Indigenous Australians Age Prematurely? The Implications Of Life Expectancy And Health Conditions Of Older Indigenous People For Health And Aged Care Policy, Philippa R. Cotter, John R. Condon, Tony Barnes, Ian P.S. Anderson, Leonard R. Smith, Teresa Cunningham

Aboriginal Policy Research Consortium International (APRCi)

Objective. To assess whether Indigenous Australians age prematurely compared with other Australians, as implied by Australian Government aged care policy, which uses age 50 years and over for population-based planning for Indigenous people compared with 70 years for non-indigenous people.

Methods. Cross-sectional analysis of aged care assessment, hospital and health survey data comparing Indigenous and non-indigenous age-specific prevalence of health conditions. Analysis of life tables for Indigenous and non-indigenous populations comparing life expectancy at different ages.

Results. At age 63 for women and age 65 for men, Indigenous people had the same life expectancy as non-indigenous people at age 70. …