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Full-Text Articles in Social and Behavioral Sciences
Impaired Synaptic Development In A Maternal Immune Activation Mouse Model Of Neurodevelopmental Disorders, Pierluca Coiro, Ragunathan Padmashri, Anand Suresh, Elizabeth Spartz, Gurudutt Pendyala, Shinnyi Chou, Yoosun Jung, Brittney Meays, Shreya Roy, Nagsen Gautam, Yazen Alnouti, Ming Li, Anna Dunaevsky
Impaired Synaptic Development In A Maternal Immune Activation Mouse Model Of Neurodevelopmental Disorders, Pierluca Coiro, Ragunathan Padmashri, Anand Suresh, Elizabeth Spartz, Gurudutt Pendyala, Shinnyi Chou, Yoosun Jung, Brittney Meays, Shreya Roy, Nagsen Gautam, Yazen Alnouti, Ming Li, Anna Dunaevsky
Department of Psychology: Faculty Publications
Both genetic and environmental factors are thought to contribute to neurodevelopmental and neuropsychiatric disorders with maternal immune activation (MIA) being a risk factor for both autism spectrum disorders and schizophrenia. Although MIA mouse offspring exhibit behavioral impairments, the synaptic alterations in vivo that mediate these behaviors are not known. Here we employed in vivo multiphoton imaging to determine that in the cortex of young MIA offspring there is a reduction in number and turnover rates of dendritic spines, sites of majority of excitatory synaptic inputs. Significantly, spine impairments persisted into adulthood and correlated with increased repetitive behavior, an ASD relevant …
The Role Of Anger Rumination And Autism Spectrum Disorder– Linked Perseveration In The Experience Of Aggression In The General Population, Cara E. Pugliese, Matthew S. Fritz, Susan W. White
The Role Of Anger Rumination And Autism Spectrum Disorder– Linked Perseveration In The Experience Of Aggression In The General Population, Cara E. Pugliese, Matthew S. Fritz, Susan W. White
Department of Educational Psychology: Faculty Publications
This study (a) examined the role of anger rumination as a mediator of the relation between social anxiety and the experience of anger, hostility, and aggression, in the general population, and (b) evaluated the degree to which the presence of autism spectrum disorder characteristics moderates the indirect influence of anger rumination. We then explored whether social cognition and perseveration characteristic of autism spectrum disorder uniquely accounted for the predicted moderation. In this survey study of young adults (n = 948), anger rumination mediated the relation between social anxiety and hostility, as well as verbal and physical aggression, as predicted. Greater …