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Full-Text Articles in Social and Behavioral Sciences
Individual Characteristics And Their Effect On Predicting Mu Rhythm Modulation, Adriane Randolph, Melody Jackson, Saurav Karmakar
Individual Characteristics And Their Effect On Predicting Mu Rhythm Modulation, Adriane Randolph, Melody Jackson, Saurav Karmakar
Adriane B. Randolph
Brain-computer interfaces (BCIs) offer users with severe motor disabilities a nonmuscular input channel for communication and control but require that users achieve a level of literacy and be able to harness their appropriate electrophysiological responses for effective use of the interface. There is currently no formalized process for determining a user's aptitude for control of various BCIs without testing on an actual system. This study presents how basic information captured about users may be used to predict modulation of mu rhythms, electrical variations in the motor cortex region of the brain that may be used for control of a BCI. …
Escherichia Coli Single-Stranded Dna-Binding Protein: Nanoesi-Ms Studies Of Salt-Modulated Subunit Exchange And Dna Binding Transactions, Claire E. Mason, Slobodan Jergic, Allen Lo, Yao Wang, Nicholas E. Dixon, Jennifer L. Beck
Escherichia Coli Single-Stranded Dna-Binding Protein: Nanoesi-Ms Studies Of Salt-Modulated Subunit Exchange And Dna Binding Transactions, Claire E. Mason, Slobodan Jergic, Allen Lo, Yao Wang, Nicholas E. Dixon, Jennifer L. Beck
Professor Nick E Dixon
Single-stranded DNA-binding proteins (SSBs) are ubiquitous oligomeric proteins that bind with very high affinity to single-stranded DNA and have a variety of essential roles in DNA metabolism. Nanoelectrospray ionization mass spectrometry (nanoESI-MS) was used to monitor subunit exchange in full-length and truncated forms of the homotetrameric SSB from Escherichia coli. Subunit exchange in the native protein was found to occur slowly over a period of hours, but was significantly more rapid in a truncated variant of SSB from which the eight C-terminal residues were deleted. This effect is proposed to result from C-terminus mediated stabilization of the SSB tetramer, in …
Characterization Of Cleavage Events In The Multifunctional Cilium Adhesin Mhp684 (P146) Reveals A Mechanism By Which Mycoplasma Hyopneumoniae Regulates Surface Topography, Daniel Bogema, Ania T. Deutscher, Lauren K. Woolley, Lisa M. Seymour, Benjamin B. A Raymond, Jessica L. Tacchi, Matthew P. Padula, Nicholas E. Dixon, F Chris Minion, Cheryl Jenkins, Mark J. Walker, Steven P. Djordjevic
Characterization Of Cleavage Events In The Multifunctional Cilium Adhesin Mhp684 (P146) Reveals A Mechanism By Which Mycoplasma Hyopneumoniae Regulates Surface Topography, Daniel Bogema, Ania T. Deutscher, Lauren K. Woolley, Lisa M. Seymour, Benjamin B. A Raymond, Jessica L. Tacchi, Matthew P. Padula, Nicholas E. Dixon, F Chris Minion, Cheryl Jenkins, Mark J. Walker, Steven P. Djordjevic
Professor Nick E Dixon
Mycoplasma hyopneumoniae causes enormous economic losses to swine production worldwide by colonizing the ciliated epithelium in the porcine respiratory tract, resulting in widespread damage to the mucociliary escalator, prolonged inflammation, reduced weight gain, and secondary infections. Protein Mhp684 (P146) comprises 1,317 amino acids, and while the N-terminal 400 residues display significant sequence identity to the archetype cilium adhesin P97, the remainder of the molecule is novel and displays unusual motifs. Proteome analysis shows that P146 preprotein is endogenously cleaved into three major fragments identified here as P50P146, P40P146, and P85P146 that reside on the cell surface. Liquid chromatography with tandem …
Structure Of The Theta Subunit Of Escherichia Coli Dna Polymerase Iii In Complex With The Epsilon Subunit, Max A Keniry, Ah-Young Park, Elisabeth A. Owen, Samir M. Hamdan, Guido Pintacuda, Gottfried Otting, Nicholas E. Dixon
Structure Of The Theta Subunit Of Escherichia Coli Dna Polymerase Iii In Complex With The Epsilon Subunit, Max A Keniry, Ah-Young Park, Elisabeth A. Owen, Samir M. Hamdan, Guido Pintacuda, Gottfried Otting, Nicholas E. Dixon
Professor Nick E Dixon
The catalytic core of Escherichia coli DNA polymerase III contains three tightly associated subunits, the α, ε, and θ subunits. The θ subunit is the smallest and least understood subunit. The three-dimensional structure of θ in a complex with the unlabeled N-terminal domain of the ε subunit, ε186, was determined by multidimensional nuclear magnetic resonance spectroscopy. The structure was refined using pseudocontact shifts that resulted from inserting a lanthanide ion (Dy3+, Er3+, or Ho3+) at the active site of ε186. The structure determination revealed a three-helix bundle fold that is similar to the solution structures of θ in a methanol-water …
Replication Termination In Escherichia Coli: Structure And Anti-Helicase Activity Of The Tus-Ter Complex, Cameron Neylon, Andrew V. Kralicek, Thomas M. Hill, Nicholas E. Dixon
Replication Termination In Escherichia Coli: Structure And Anti-Helicase Activity Of The Tus-Ter Complex, Cameron Neylon, Andrew V. Kralicek, Thomas M. Hill, Nicholas E. Dixon
Professor Nick E Dixon
The arrest of DNA replication in Escherichia coli is triggered by the encounter of a replisome with a Tus protein-Ter DNA complex. A replication fork can pass through a Tus-Ter complex when traveling in one direction but not the other, and the chromosomal Ter sites are oriented so replication forks can enter, but not exit, the terminus region. The Tus-Ter complex acts by blocking the action of the replicative DnaB helicase, but details of the mechanism are uncertain. One proposed mechanism involves a specific interaction between Tus-Ter and the helicase that prevents further DNA unwinding, while another is that the …
Proofreading Exonuclease On A Tether: The Complex Between The E. Coli Dna Polymerase Iii Subunits Α, Ε, Θ And Β Reveals A Highly Flexible Arrangement Of The Proofreading Domain, Kiyoshi Ozawa, Nicholas P. Horan, Andrew Robinson, Hiromasa Yagi, Flynn R. Hill, Slobodan Jergic, Zhi-Qiang Xu, Karin V. Loscha, Nan Li, Moeava Tehei, Aaron J. Oakley, Gottfried Otting, Thomas Huber, Nicholas E. Dixon
Proofreading Exonuclease On A Tether: The Complex Between The E. Coli Dna Polymerase Iii Subunits Α, Ε, Θ And Β Reveals A Highly Flexible Arrangement Of The Proofreading Domain, Kiyoshi Ozawa, Nicholas P. Horan, Andrew Robinson, Hiromasa Yagi, Flynn R. Hill, Slobodan Jergic, Zhi-Qiang Xu, Karin V. Loscha, Nan Li, Moeava Tehei, Aaron J. Oakley, Gottfried Otting, Thomas Huber, Nicholas E. Dixon
Professor Nick E Dixon
A complex of the three (αεθ) core subunits and the β2 sliding clamp is responsible for DNA synthesis by Pol III, the Escherichia coli chromosomal DNA replicase. The 1.7 Å crystal structure of a complex between the PHP domain of α (polymerase) and the C-terminal segment of ε (proofreading exonuclease) subunits shows that ε is attached to α at a site far from the polymerase active site. Both α and ε contain clamp-binding motifs (CBMs) that interact simultaneously with β2 in the polymerization mode of DNA replication by Pol III. Strengthening of both CBMs enables isolation of stable αεθ:β2 complexes. …
Flexibility Revealed By The 1.85 Å Crystal Structure Of The Β Sliding-Clamp Subunit Of Escherichia Coli Dna Polymerase Iii, Aaron J. Oakley, Pavel Prosselkov, Gene Wijffels, Jennifer L. Beck, Matthew Cj Wilce, Nicholas E. Dixon
Flexibility Revealed By The 1.85 Å Crystal Structure Of The Β Sliding-Clamp Subunit Of Escherichia Coli Dna Polymerase Iii, Aaron J. Oakley, Pavel Prosselkov, Gene Wijffels, Jennifer L. Beck, Matthew Cj Wilce, Nicholas E. Dixon
Professor Nick E Dixon
The subunit of the Escherichia coli replicative DNA polymerase III holoenzyme is the sliding clamp that interacts with the (polymerase) subunit to maintain the high processivity of the enzyme. The protein is a ring-shaped dimer of 40.6 kDa subunits whose structure has previously been determined at a resolution of 2.5 Å [Kong et al. (1992), Cell, 69, 425-437]. Here, the construction of a new plasmid that directs overproduction of to very high levels and a simple procedure for large-scale purification of the protein are described. Crystals grown under slightly modified conditions diffracted to beyond 1.9 Å at 100 K at …
Before You Write: Six Keys To Success – A Pilot Online Information Literacy Course For Graduate Nursing Students, Shannon F. Johnson, Tammy Toscos
Before You Write: Six Keys To Success – A Pilot Online Information Literacy Course For Graduate Nursing Students, Shannon F. Johnson, Tammy Toscos
Shannon F Johnson
In this article, the authors share their experiences with the creation and implementation of an online self-paced information literacy instruction for graduate students of nursing. Before You Write: Six Keys to success is a non-credit required online course attached to the Indiana University - Purdue University Fort Wayne (IPFW) graduate nursing program. The rationale behind the creation of the course was to help graduate students recognize areas where their information literacy skills may be lacking or have become outdated and provide them with tools to increase their proficiency, while still early in their first semester of the program. It consists …
New Ages For Human Occupation And Climatic Change At Lake Mungo Australia, James Bowler, Harvey Johnston, Jon M Olley, John Prescott, Richard Roberts, Wilfred Shawcross, Nigel Spooner
New Ages For Human Occupation And Climatic Change At Lake Mungo Australia, James Bowler, Harvey Johnston, Jon M Olley, John Prescott, Richard Roberts, Wilfred Shawcross, Nigel Spooner
Richard G Roberts
Australia’s oldest human remains, found at Lake Mungo, include the world’s oldest ritual ochre burial (Mungo III) and the first recorded cremation (Mungo I). Until now, the importance of these finds has been constrained by limited chronologies and palaeoenvironmental information. Mungo III, the source of the world’s oldest human mitochondrial DNA, has been variously estimated at 30 thousand years (kyr) old, 42–45 kyr old and 62 +/- 6 kyr old. while radiocarbon estimates placed theMungo I cremation near 20–26 kyr ago. Here we report a new series of 25 optical ages showing that both burials occurred at 40 +/- 2 …
Archaeology And Age Of A New Hominin From Flores, In Eastern Indonesia, Michael Morwood, R Soejono, Richard Roberts, T. Sutikna, Christian Turney, Kira Westaway, W Rink, Jian-Xin Zhao, Gerrit Van Den Bergh, Rokhus Awe Due, Douglas Hobbs, M Moore, M Bird, L Fifield
Archaeology And Age Of A New Hominin From Flores, In Eastern Indonesia, Michael Morwood, R Soejono, Richard Roberts, T. Sutikna, Christian Turney, Kira Westaway, W Rink, Jian-Xin Zhao, Gerrit Van Den Bergh, Rokhus Awe Due, Douglas Hobbs, M Moore, M Bird, L Fifield
Richard G Roberts
Excavations at Liang Bua, a large limestone cave on the island of Flores in eastern Indonesia, have yielded evidence for a population of tiny hominins, sufficiently distinct anatomically to be assigned to a new species, Homo floresiensis1. The finds comprise the cranial and some post-cranial remains of one individual, as well as a premolar from another individual in older deposits. Here we describe their context, implications and the remaining archaeological uncertainties. Dating by radiocarbon (14C), luminescence, uranium-series and electron spin resonance (ESR) methods indicates that H. floresiensis existed from before 38,000 years ago (kyr) until at …
Sources Of Overdispersion In A K-Rich Feldspar Sample From North-Central India: Insights From De, K Content And Irsl Age Distributions For Individual Grains, C Neudorf, Richard Roberts, Z Jacobs
Sources Of Overdispersion In A K-Rich Feldspar Sample From North-Central India: Insights From De, K Content And Irsl Age Distributions For Individual Grains, C Neudorf, Richard Roberts, Z Jacobs
Richard G Roberts
Luminescence dating of individual sand-sized grains of quartz is a well-established technique in Quaternary geochronology, but the most ubiquitous mineral on the surface of the Earth—feldspar—has received much less attention at the single-grain level. In this study, we estimated single-grain equivalent dose values and infrared stimulated luminescence (IRSL) ages for K-rich feldspar (KF) grains from a fluvial sample underlying Youngest Toba Tuff (YTT) deposits in north-central India, and compared these ages (corrected for anomalous fading) with those obtained from individual grains of quartz from the same sample. Both minerals have broadly similar single-grain age distributions, but both are greatly overdispersed …
Time Matters, Richard Roberts, M F Smith
New Ages For The Last Australian Megafauna: Continent Wide Extinction About 46,000 Years Ago, Richard Roberts, T Flannery, Linda Ayliffe, Hiroyuki Yoshida, Jon M Olley, Gavin Prideaux, G Laslett, A Baynes, M Smith, Richard Jones, B Smith
New Ages For The Last Australian Megafauna: Continent Wide Extinction About 46,000 Years Ago, Richard Roberts, T Flannery, Linda Ayliffe, Hiroyuki Yoshida, Jon M Olley, Gavin Prideaux, G Laslett, A Baynes, M Smith, Richard Jones, B Smith
Richard G Roberts
No abstract provided.
Archaeology: Progress And Pitfalls In Radiocarbon Dating, Christian Turney, Richard Roberts, Zenobia Jacobs
Archaeology: Progress And Pitfalls In Radiocarbon Dating, Christian Turney, Richard Roberts, Zenobia Jacobs
Richard G Roberts
No abstract provided.
Tight Entrance Cave, Southwestern Australia: A Late Pleistocene Vertebrate Deposit Spanning More Than 180 Ka, Gavin Prideaux, G Gully, Linda Ayliffe, M Bird, Richard Roberts
Tight Entrance Cave, Southwestern Australia: A Late Pleistocene Vertebrate Deposit Spanning More Than 180 Ka, Gavin Prideaux, G Gully, Linda Ayliffe, M Bird, Richard Roberts
Richard G Roberts
No abstract provided.
A Bayesian Approach To The Evaluation Of Equivalent Doses In Sediment Mixtures For Luminescence Dating, D Sivia, C Burbidge, Richard Roberts, Richard Bailey
A Bayesian Approach To The Evaluation Of Equivalent Doses In Sediment Mixtures For Luminescence Dating, D Sivia, C Burbidge, Richard Roberts, Richard Bailey
Richard G Roberts
No abstract provided.
The People Time Forgot, Richard Roberts, Michael Morwood, T. Sutikna
The People Time Forgot, Richard Roberts, Michael Morwood, T. Sutikna
Richard G Roberts
No abstract provided.
Human History Written In Stone And Blood, Zenobia Jacobs, Richard Roberts
Human History Written In Stone And Blood, Zenobia Jacobs, Richard Roberts
Richard G Roberts
Even by archaeological standards, Blombos Cave is a modestly sized shelter. Yet artifacts recovered from just 13 cubic meters of deposit inside transformed our understanding of when our species developed behavioral attributes we associate with “modern” humans. From this cramped hole in a sandstone cliff on the Southern Cape coast of South Africa, Christopher Henshilwood and his colleagues unearthed evidence of symbolic expression, in the form of abstract designs (carved ochre bars) and personal ornaments (shell beads) at least 70,000 years old. That is more than 35,000 years before anything comparable emerged in Europe.
Elemental Delta C-13 At Allen's Cave, Nullarbor Plain, Australia: Assessing Post-Depositional Disturbance And Reconstructing Past Environments, C Turney, M Bird, Richard Roberts
Elemental Delta C-13 At Allen's Cave, Nullarbor Plain, Australia: Assessing Post-Depositional Disturbance And Reconstructing Past Environments, C Turney, M Bird, Richard Roberts
Richard G Roberts
No abstract provided.
Obituary: Professor Rhys Jones, Ao, Richard Roberts
Obituary: Professor Rhys Jones, Ao, Richard Roberts
Richard G Roberts
No abstract provided.
Orang Kedil Dari Dunia Yang Hilung, Michael Morwood, T. Sutikna, Richard Roberts
Orang Kedil Dari Dunia Yang Hilung, Michael Morwood, T. Sutikna, Richard Roberts
Richard G Roberts
No abstract provided.
Optical Dating Of Deep-Sea Sediments Using Single Grains Of Quartz: A Comparison With Radiocarbon, Jon M Olley, Patrick De Deckker, Richard Roberts, L Fifield, Hiroyuki Yoshida, G Hancock
Optical Dating Of Deep-Sea Sediments Using Single Grains Of Quartz: A Comparison With Radiocarbon, Jon M Olley, Patrick De Deckker, Richard Roberts, L Fifield, Hiroyuki Yoshida, G Hancock
Richard G Roberts
No abstract provided.
On The Reliability Of Age Estimates For Human Remains At Lake Mungo, Richard Gillespie, Richard Roberts
On The Reliability Of Age Estimates For Human Remains At Lake Mungo, Richard Gillespie, Richard Roberts
Richard G Roberts
The lunettes that fringe the ancient shorelines of Lake Mungo, in the Willandra Lakes region of southeastern Australia, have been a source of sustained archaeological and environmental interest since 1968, when Jim Bowler found the first of many recently exposed human burials. Most attention has been directed toward the Mungo 1 and Mungo 3 burials, excavated from the southern end of the ‘‘Walls of China’’ lunette (Bowler et al., 1970, 1972; Bowler & Thorne, 1976). More than 200 radiocarbon (14C) and thermoluminescence (TL) age estimates have since been obtained from a wide range of materials associated with human occupation and …
Mid-Holocene Age Obtained For Nested Diamond Pattern Petroglyph In The Billasurgam Cave Complex, Kurnool District, Southern India, Paul S.C Tacon, Nicole Boivin, Michael Petraglia, James Blinkhorn, Allan Chivas, Richard G. Roberts, David Fink, Thomas Higham, Peter Ditchfield, Ravi Korisettar, Jian-Xin Zhao
Mid-Holocene Age Obtained For Nested Diamond Pattern Petroglyph In The Billasurgam Cave Complex, Kurnool District, Southern India, Paul S.C Tacon, Nicole Boivin, Michael Petraglia, James Blinkhorn, Allan Chivas, Richard G. Roberts, David Fink, Thomas Higham, Peter Ditchfield, Ravi Korisettar, Jian-Xin Zhao
Richard G Roberts
India has one of the world's largest and most significant bodies of rock paintings and engravings, yet not a single rock art site or image has been directly and accurately dated using radiometric techniques. Here we report on results from the Billasurgam Cave complex near Kurnool in southern India. Although this cave complex has been investigated archaeologically since the late 1800s, it was not until 2008 that a large petroglyph, consisting of the remains of three nested diamond designs on a stalactite, was noted. In order to determine if this petroglyph had been made recently, flowstone was sampled from on …
Radiocarbon Dating Of Organic- And Carbonate-Carbon In Genyornis And Dromaius Eggshell Using Stepped Combustion And Stepped Acidification, M Bird, C Turney, L Fifield, M Smith, G Miller, Richard Roberts, John Magee
Radiocarbon Dating Of Organic- And Carbonate-Carbon In Genyornis And Dromaius Eggshell Using Stepped Combustion And Stepped Acidification, M Bird, C Turney, L Fifield, M Smith, G Miller, Richard Roberts, John Magee
Richard G Roberts
No abstract provided.
Sample Collection For Analytical Study And Scientific Dating Of The Early Indian Petroglyphs And Rock Paintings By The International Commission, G Kumar, R Bednarik, A Watchman, Richard Roberts, E Lawson, C Patterson
Sample Collection For Analytical Study And Scientific Dating Of The Early Indian Petroglyphs And Rock Paintings By The International Commission, G Kumar, R Bednarik, A Watchman, Richard Roberts, E Lawson, C Patterson
Richard G Roberts
No abstract provided.
Dating Middle-Earth, Christian Turney, Richard Roberts, Kira Westaway
Dating Middle-Earth, Christian Turney, Richard Roberts, Kira Westaway
Richard G Roberts
The article presents information on determining the features of a new species of primitive human discovered called hobbits. The ancient anatomical features of the skeleton shared many similarities with 1.8-million-year-old human remains found at Dmanisi in the Republic of Georgia. So researchers anticipated it to be at least hundreds of thousands of years old. But because the skeletal remains were the only known examples of an entirely new species, we could not afford to destroy any of it by using direct dating methods that consumed any bones or teeth. Parts of the skeleton were still articulated, indicating "Hobbit" had died …
Early Human Occupation At Devil's Lair, South-Western Australia, Christian Turney, M Bird, L K Fifield, Richard Roberts, Michael Smith, C Dortch, R. Grun, E Lawson, Linda Ayliffe, G Miller, J Dortch, R Creswell
Early Human Occupation At Devil's Lair, South-Western Australia, Christian Turney, M Bird, L K Fifield, Richard Roberts, Michael Smith, C Dortch, R. Grun, E Lawson, Linda Ayliffe, G Miller, J Dortch, R Creswell
Richard G Roberts
No abstract provided.
Optical Dating Of Holocene Sediments From A Variety Of Geomorphic Settings Using Single Grains Of Quartz, Jon M Olley, Tim Pietsch, Richard Roberts
Optical Dating Of Holocene Sediments From A Variety Of Geomorphic Settings Using Single Grains Of Quartz, Jon M Olley, Tim Pietsch, Richard Roberts
Richard G Roberts
No abstract provided.
Archaeology And Australian Megafauna, Richard Roberts, Hiroyuki Yoshida, T Flannery, Linda Ayliffe, Jon M Olley, Gavin Prideaux, G Laslett, A Baynes, M Smith, Richard Jones, B Smith
Archaeology And Australian Megafauna, Richard Roberts, Hiroyuki Yoshida, T Flannery, Linda Ayliffe, Jon M Olley, Gavin Prideaux, G Laslett, A Baynes, M Smith, Richard Jones, B Smith
Richard G Roberts
No abstract provided.