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Full-Text Articles in Social and Behavioral Sciences
Revised Age For Mojokerto 1, An Early Homo Erectus Cranium From East Java, Indonesia, Michael Morwood, P O'Sullivan, E E. Susanto, F Aziz
Revised Age For Mojokerto 1, An Early Homo Erectus Cranium From East Java, Indonesia, Michael Morwood, P O'Sullivan, E E. Susanto, F Aziz
Faculty of Science, Medicine and Health - Papers: part A
Dates of around 1.8 Ma have been claimed for a hominin cranial vault excavated near Mojokerto City in East Java, Indonesia. Such an early date for presumed Homo erectus in East Asia would require a major revision of the general model for timing of initial hominin dispersal 'Out of Africa'. Instead, our field study and redating of two pumice horizons at the site indicate that the age of the Mojokerto cranial vault is less than 1.49 Ma. Furthermore, we argue that a basic understanding of site and regional depositional processes is fundamental for assessing the significance of any radiometric date.
Flexibility Revealed By The 1.85 Å Crystal Structure Of The Β Sliding-Clamp Subunit Of Escherichia Coli Dna Polymerase Iii, Aaron J. Oakley, Pavel Prosselkov, Gene Wijffels, Jennifer L. Beck, Matthew Cj Wilce, Nicholas E. Dixon
Flexibility Revealed By The 1.85 Å Crystal Structure Of The Β Sliding-Clamp Subunit Of Escherichia Coli Dna Polymerase Iii, Aaron J. Oakley, Pavel Prosselkov, Gene Wijffels, Jennifer L. Beck, Matthew Cj Wilce, Nicholas E. Dixon
Faculty of Science, Medicine and Health - Papers: part A
The subunit of the Escherichia coli replicative DNA polymerase III holoenzyme is the sliding clamp that interacts with the (polymerase) subunit to maintain the high processivity of the enzyme. The protein is a ring-shaped dimer of 40.6 kDa subunits whose structure has previously been determined at a resolution of 2.5 Å [Kong et al. (1992), Cell, 69, 425-437]. Here, the construction of a new plasmid that directs overproduction of to very high levels and a simple procedure for large-scale purification of the protein are described. Crystals grown under slightly modified conditions diffracted to beyond 1.9 Å at 100 …
Stx1c Is The Most Common Shiga Toxin 1 Subtype Among Shiga Toxin-Producing Escherichia Coli Isolates From Sheep But Not Among Isolates From Cattle, Kim Brett, Vidiya Ramachandran, Michael A Hornitzky, Karl A Bettelheim, Mark J. Walker, Steven P. Djordjevic
Stx1c Is The Most Common Shiga Toxin 1 Subtype Among Shiga Toxin-Producing Escherichia Coli Isolates From Sheep But Not Among Isolates From Cattle, Kim Brett, Vidiya Ramachandran, Michael A Hornitzky, Karl A Bettelheim, Mark J. Walker, Steven P. Djordjevic
Faculty of Science, Medicine and Health - Papers: part A
Unlike Shiga toxin 2 (stx2) genes, most nucleotide sequences of Shiga toxin 1 (stx1) genes from Shiga toxin-producing Escherichia coli (STEC), Shigella dysenteriae, and several bacteriophages (H19B, 933J, and H30) are highly conserved. Consequently, there has been little incentive to investigate variants of stx1 among STEC isolates derived from human or animal sources. However stx1OX3, originally identified in an OX3:H8 isolate from a healthy sheep in Germany, differs from other stx1 subtypes by 43 nucleotides, resulting in changes to 12 amino acid residues, and has been renamed stx1c …