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Full-Text Articles in Social and Behavioral Sciences
Bone Mineral Density In Hiv Participants Randomized To Raltegravir And Lopinavir/Ritonavir Compared With Standard Second Line Therapy, Allison Martin, Cecilia L. Moore, Patrick W. G Mallon, Jennifer F. Hoy, Sean Emery, Waldo H. Belloso, Praphan Phanuphak, Samuel Ferret, David A. Cooper, Mark A. Boyd
Bone Mineral Density In Hiv Participants Randomized To Raltegravir And Lopinavir/Ritonavir Compared With Standard Second Line Therapy, Allison Martin, Cecilia L. Moore, Patrick W. G Mallon, Jennifer F. Hoy, Sean Emery, Waldo H. Belloso, Praphan Phanuphak, Samuel Ferret, David A. Cooper, Mark A. Boyd
Allison Humphries Dr
Objective: To compare changes over 48 weeks in bone mineral density (BMD) between participants randomized to lopinavir/ritonavir (LPV/r) + raltegravir (RAL) or LPV/r + 2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) as second line therapy. Design: 48-week open-label sub-study of the Second Line trial conducted in South Africa, India, Thailand, Malaysia and Argentina. Methods: Dual energy X-ray absorptiometry scans of proximal femur and lumbar spine were performed at baseline and week 48. Linear regression was used to compare means of differences between arms. McNemars test compared osteopenia and osteoporosis. Associations between percentage BMD changes and baseline variables were assessed by multivariate …
Simplification With Fixed-Dose Tenofovir-Emtricitabine Or Abacavir-Lamivudine In Treatment Experienced, Virologically Suppressed Adults With Hiv Infection: Combined Analysis Of Two Randomised, Non-Inferiority Trials Bicombo And Steal, Janaki Amin, E De Lazzari, Sean Emery, Allison Martin, E Martinez, Andrew Carr, J Gatell, David A. Cooper
Simplification With Fixed-Dose Tenofovir-Emtricitabine Or Abacavir-Lamivudine In Treatment Experienced, Virologically Suppressed Adults With Hiv Infection: Combined Analysis Of Two Randomised, Non-Inferiority Trials Bicombo And Steal, Janaki Amin, E De Lazzari, Sean Emery, Allison Martin, E Martinez, Andrew Carr, J Gatell, David A. Cooper
Allison Humphries Dr
Background: There is uncertainty about the comparative safety and effi cacy of the fi xed-dose-combination tablets tenofovir 300mg+emtricitabine 200mg (TDF/FTC); and abacavir 600mg+lamivudine 300mg (ABC/3TC). Methods: We used random effects meta-analysis to compare 96 week data for ABC/3TC and TDF/FTC randomised arms from the BICOMBO (n=333) and STEAL (n=357) treatment experienced and virologically suppressed switch studies. Endpoints included: virological failure (VF, repeat plasma HIV RNA >400 copies/mL); mean change to week 96 in CD4 and metabolic parameters; proportion with serious non-AIDS events (SNAEs, retrospectively collected in BICOMBO). We used exact statistics for relative difference in proportions (RD), and ANOVA for …
Hiv Lipodystrophy In Participants Randomised To Lopinavir/Ritonavir (Lpv/R) +2-3 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (N(T)Rti) Or Lpv/R + Raltegravir As Second-Line Antiretroviral Therapy, Allison Martin, Cecilia L. Moore, Patrick W. G Mallon, Jennifer F. Hoy, Sean Emery, Waldo H. Belloso, Praphan Phanuphak, Samuel Ferret, David A. Cooper, Mark A. Boyd
Hiv Lipodystrophy In Participants Randomised To Lopinavir/Ritonavir (Lpv/R) +2-3 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (N(T)Rti) Or Lpv/R + Raltegravir As Second-Line Antiretroviral Therapy, Allison Martin, Cecilia L. Moore, Patrick W. G Mallon, Jennifer F. Hoy, Sean Emery, Waldo H. Belloso, Praphan Phanuphak, Samuel Ferret, David A. Cooper, Mark A. Boyd
Allison Humphries Dr
Objective To compare changes over 48 weeks in body fat, lipids, Metabolic Syndrome and cardiovascular disease risk between patients randomised 1:1 to lopinavir/ritonavir (r/LPV) plus raltegravir (RAL) compared to r/LPV plus 2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) as second-line therapy. Methods Participants were HIV-1 positive (>16 years) failing first-line treatment (2 consecutive HIV RNA >500 copies/mL) of NNRTI +2N(t)RTI. Whole body dual energy x-ray absorptiometry was performed at baseline and week 48. Data were obtained to calculate the Metabolic Syndrome and Framingham cardiovascular disease (CVD) risk score. Linear regression was used to compare mean differences between arms. Logistic regression …
Interdisciplinary Lifestyle Intervention: A Pilot Study Of Effects On Weight Loss, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Joseph Russell, Allison Humphries
Interdisciplinary Lifestyle Intervention: A Pilot Study Of Effects On Weight Loss, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Joseph Russell, Allison Humphries
Allison Humphries Dr
Abstract of a presentation that was present at the NSA 2014 Annual Scientific Meeting, 26-28 November, Hobart, Australia.