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Full-Text Articles in Social and Behavioral Sciences
All Chronic Rhinosinusitis Endotype Clusters Demonstrate Improvement In Patient Reported And Clinical Outcome Measures After Endoscopic Sinus Surgery, Nikita Chapurin, Rodney J. Schlosser, Jorge Gutierrez, Jess C. Mace, Todd Bodner, Timothy L. Smith, Jose L. Mattos, Vijay R. Ramakrishnan, Jeremiah Alt, Zachary M. Soler
All Chronic Rhinosinusitis Endotype Clusters Demonstrate Improvement In Patient Reported And Clinical Outcome Measures After Endoscopic Sinus Surgery, Nikita Chapurin, Rodney J. Schlosser, Jorge Gutierrez, Jess C. Mace, Todd Bodner, Timothy L. Smith, Jose L. Mattos, Vijay R. Ramakrishnan, Jeremiah Alt, Zachary M. Soler
Psychology Faculty Publications and Presentations
Background
It is unclear if chronic rhinosinusitis (CRS) endotypes show differential response to endoscopic sinus surgery (ESS). We explored mucus inflammatory cytokine expression in a cohort with CRS and associations with both patient-reported and clinically measured postoperative outcome measures.
Methods
Patients with CRS were prospectively recruited between 2016-2021 into a multi-center observational study. Mucus was collected from the olfactory cleft preoperatively and evaluated for 26 biomarkers using cluster analysis. Patient reported outcome measures included the Sino-Nasal Outcome Test (SNOT-22) and Questionnaire of Olfactory Dysfunction (QOD). Additional clinical measures of disease severity included Threshold, Discrimination, and Identification (TDI) scores using Sniffin’ …