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Full-Text Articles in Social and Behavioral Sciences
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Danielle Skropeta
To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20 analogues incorporating a ring system between the N1 and C7 atoms of isatin were prepared using a variety of synthetic strategies. This yielded pyrroloindole-, pyrroloquinoline-, pyrroloacridine-, pyrrolophenanthridine- and benzopyrrolophenanthridine-based systems with embedded isatin moieties, the latter possessing a novel carbon skeleton. These compounds were subsequently assessed for their in vitro cytotoxicity against human U937 lymphoma cells, with the brominated pyrroloacridine dione 27 showing the most promising activity (IC50 3.01 μM) after 24 h.
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Mark R Wilson
Alzheimer's disease is characterised by the inappropriate death of brain cells and accumulation of the A beta peptide in the brain. Thus, it is possible that there are fundamental differences between Alzheimer's disease patients and healthy individuals in their abilities to clear A beta from brain fluid and to protect neurons from A beta toxicity. In the present study, we examined (1) the cytotoxicity of Alzheimer's disease cerebrospinal fluid (CSF) compared to control CSF, (2) the ability of Alzheimer's disease and control CSF to protect cells from A beta toxicity and to promote cell-mediated clearance of A beta and lastly …
Infrared Spectra Of The Li +_(H 2)N(N=1-3) Cation Complexes, C Emmeluth, B L. J Poad, C D. Thompson, G H. Weddle, E J. Bieske
Infrared Spectra Of The Li +_(H 2)N(N=1-3) Cation Complexes, C Emmeluth, B L. J Poad, C D. Thompson, G H. Weddle, E J. Bieske
Berwyck L. J. Poad
The Li+–(H2)n n = 1–3 complexes are investigated through infrared spectra recorded in the H–H stretch region (3980–4120 cm−1) and through ab initio calculations at the MP2∕aug-cc-pVQZ level. The rotationally resolved H–H stretch band of Li+–H2 is centered at 4053.4 cm−1 [a −108 cm−1 shift from the Q1(0) transition of H2]. The spectrum exhibits rotational substructure consistent with the complex possessing a T-shaped equilibrium geometry, with the Li+ ion attached to a slightly perturbed H2 molecule. Around 100 rovibrational transitions belonging to parallel Ka = 0‐0, 1-1, 2-2, and 3-3 subbands are observed. The Ka = 0‐0 and 1-1 transitions …
Infrared Spectra Of Mass-Selected Al+_(Ch4)Nn=1-6clusters, B Poad, C Thompson, E Bieske
Infrared Spectra Of Mass-Selected Al+_(Ch4)Nn=1-6clusters, B Poad, C Thompson, E Bieske
Berwyck L. J. Poad
Infrared spectra are recorded for Al+–(CH4)n n = 1–6 clusters in the CH stretch region (2800–3100 cm−1). The spectra, which are obtained by monitoring photofragmentation in a tandem mass spectrometer, are dominated by a single, narrow band corresponding to the totally symmetric C–H stretching mode of the CH4 subunits (rendered infrared active through the interaction with the Al+ cation). This band shifts progressively to higher wavenumber as the clusters becomes larger, concomitant with a weakening of the intermolecular Al+⋯CH4 bonds. Supporting ab initio calculations for the n = …
Infrared Spectra Of Cl-_(C6h6)Mm=1, 2, Christopher Thompson, Berwyck Poad, Corinna Emmeluth, Evan Bieske
Infrared Spectra Of Cl-_(C6h6)Mm=1, 2, Christopher Thompson, Berwyck Poad, Corinna Emmeluth, Evan Bieske
Berwyck L. J. Poad
The Cl--(C6H6)Arn n = 0,1,2 and Cl--(C6H6)2 complexes are investigated using photodissociation infrared spectroscopy in the CH stretch region and through ab initio calculations at the MP2/aug-cc-pVDZ level. The results indicate that Cl--C6H6 possesses a planar structure in which the benzene molecule is attached to the Cl- anion by a double hydrogen bond. The calculations predict that Cl (C6H6)2 has a C2 symmetry structure in which the two face-to-face benzene molecules are attached to …