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Social and Behavioral Sciences Commons™
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- Autism spectrum disorders (2)
- Memory (2)
- Affective Behavior (1)
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- Clinical Language Understanding (1)
- Contextual fear conditioning (1)
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- Progesterone Neurosteroids (1)
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- Serum/Glucocorticoid-inducible Kinase-1 (1)
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- Temporal Reasoning (1)
Articles 1 - 4 of 4
Full-Text Articles in Social and Behavioral Sciences
Mediation Of Recurrent Hypoglycemia's Physiological And Behavioral Effects In The Hippocampus By Glucocorticoids, Danielle Osborne
Mediation Of Recurrent Hypoglycemia's Physiological And Behavioral Effects In The Hippocampus By Glucocorticoids, Danielle Osborne
Legacy Theses & Dissertations (2009 - 2024)
Recurrent hypoglycemia (RH) occurs with the over administration of insulin resulting in severe hypoglycemia on a repetitive basis. This occurs most commonly among Type I Diabetics who rely on exogenous insulin replacement for management of their disease; however it is becoming increasingly common among Type II Diabetics. Although cognitive deficits are reported during hypoglycemia, the period following restoration of euglycemia has been denoted by improved hippocampally-mediated short-term and working memory in humans and rodents, respectively. RH is also associated with an altered glucocorticoid secretion profile in response to hypoglycemia. In vitro and in vivo approaches were utilized with the goal …
Time Will Tell : Temporal Reasoning In Clinical Narratives And Beyond, Weiyi Sun
Time Will Tell : Temporal Reasoning In Clinical Narratives And Beyond, Weiyi Sun
Legacy Theses & Dissertations (2009 - 2024)
Temporal reasoning in natural language refers to the extraction and understanding of time-related information conveyed in free text. A clinical narrative temporal reasoning component can enable a spectrum of medical natural language processing (NLP) applications that directly improve patient care documentation efficiency, accessibility and accountability. This dissertation contributes in three subtasks under temporal reasoning: temporal annotation, temporal expression extraction and temporal relation inferences. The temporal annotation work described in the dissertation produced one of the first publicly available clinical narratives. We published one of the first sets of temporal
The Role Of Igf-Ii In Memory Enhancement : Implications For Autism Spectrum Disorders, Amy S. Kohtz
The Role Of Igf-Ii In Memory Enhancement : Implications For Autism Spectrum Disorders, Amy S. Kohtz
Legacy Theses & Dissertations (2009 - 2024)
Cognitive and memory impairments significantly affect multiple domains in life and play major roles in disease. Identifying critical mechanisms and factors that mediate memory consolidation and enhancement may represent an important approach for increasing cognition in normal adults and preventing or treating cognitive impairments. The expression of the C/EBP- target gene insulin-like growth factor 2, (IGF-II) is required for memory consolidation; furthermore, IGF-II administration during memory consolidation produces memory enhancement, increased memory persistence and prevents forgetting. In this thesis, I investigated the therapeutic potential of IGF-II to promote memory consolidation when administered systemically. In addition, I investigated one particularly interesting …
The Role Of Progestogen Neurosteroids In Behaviors Relevant For Autism Spectrum Disorders, Danielle Christine Llaneza
The Role Of Progestogen Neurosteroids In Behaviors Relevant For Autism Spectrum Disorders, Danielle Christine Llaneza
Legacy Theses & Dissertations (2009 - 2024)
Autism spectrum disorder (ASD) affects children across the U.S. and is characterized by deficits in social communication and restrictive/repetitive behaviors, for which few therapeutic interventions have been successful. Steroid hormones, such as progesterone (P4) and its metabolite, 5α-pregnan-3α-ol-20-one (3α,5α-THP), can exert neuroprotective effects, influence synaptic morphology, mediate behavioral outcomes, and influence stress-responding. In this thesis, the behaviors and baseline levels of the stress hormone, corticosterone, P4, and 3α,5α-THP are investigated in BTBR T+ Itpr3tf/J (BTBR) mice, a proposed ASD model. It was hypothesized that BTBR mice would show abnormalities in behaviors and in levels of steroids and neuroendocrine factors. Results …