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Full-Text Articles in Social and Behavioral Sciences
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Faculty of Science - Papers (Archive)
To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20 analogues incorporating a ring system between the N1 and C7 atoms of isatin were prepared using a variety of synthetic strategies. This yielded pyrroloindole-, pyrroloquinoline-, pyrroloacridine-, pyrrolophenanthridine- and benzopyrrolophenanthridine-based systems with embedded isatin moieties, the latter possessing a novel carbon skeleton. These compounds were subsequently assessed for their in vitro cytotoxicity against human U937 lymphoma cells, with the brominated pyrroloacridine dione 27 showing the most promising activity (IC50 3.01 μM) after 24 h.
Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly
Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly
Faculty of Health and Behavioural Sciences - Papers (Archive)
Objective: Premature termination from treatment is a major factor associated with poorer drug and alcohol treatment outcomes. The present study investigated client-related baseline predictors of dropout at 3 months from a faith-based 12-step residential drug treatment program. Method: Data were collected over a period of 14 months from eight residential drug and alcohol treatment programs run by The Australian Salvation Army. The final sample consisted of 618 participants, including 524 men (84.8%) and 94 women (15.2%). Predictor variables of interest were age, gender, primary drug of concern, criminal involvement, psychological distress, drug cravings, self-efficacy to abstain, spirituality, forgiveness of self …
Seven Out Of Ten Most Popular Vegetables Remain Top Choice During First 3 Months Of A 12 Month Weight Loss Dietary Intervention Trial, Jane O'Shea, Yasmine Probst, Rebecca Thorne, Sara Grafenauer, Linda Tapsell
Seven Out Of Ten Most Popular Vegetables Remain Top Choice During First 3 Months Of A 12 Month Weight Loss Dietary Intervention Trial, Jane O'Shea, Yasmine Probst, Rebecca Thorne, Sara Grafenauer, Linda Tapsell
Faculty of Health and Behavioural Sciences - Papers (Archive)
Increasing vegetable consumption is part of dietary advice for weight loss, but how this converts to vegetable choices is not known. In this context, our aim was to identify the main vegetable groups reported by the study sample in the Healthy Eating and Lifestyle Trial [ACTRN1260000784011] at baseline (Oct 2010-Feb 2011) and after 3mo (Feb - May 2011). Data from diet histories (DH) were analyzed using the AUSNUT 2007 database in Foodworks (Xyris, version 6.0.2562) to determine the average daily amount (g) of vegetables consumed by the study sample. Baseline DH (n=113 subjects; 85 female) exposed 32 vegetable categories. The …