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Social and Behavioral Sciences Commons™
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- Keyword
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- Aging (1)
- Behavior (1)
- Biological determinism (1)
- Chromium (1)
- Clines (1)
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- Creations of culture (1)
- Genetics (1)
- Haplotype phasing (1)
- Human social identity (1)
- IL-10 (1)
- Immune genes (1)
- Linkage disequilibrium (1)
- MAPKAP-K2 (1)
- Nemo (1)
- Neurotoxicity (1)
- Neurotoxicology (1)
- Philosophy and society (1)
- Population genetics (1)
- Range expansions (1)
- Simulations (1)
- Toxic aging coin (1)
Articles 1 - 4 of 4
Full-Text Articles in Social and Behavioral Sciences
Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee
Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee
Electronic Theses and Dissertations
We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …
Unraveling Dna And Identity: A Humanistic Perspective On Epistemologies And Ethics Of Genetic Ancestry Testing., Eve Carlisle Polley
Unraveling Dna And Identity: A Humanistic Perspective On Epistemologies And Ethics Of Genetic Ancestry Testing., Eve Carlisle Polley
Electronic Theses and Dissertations
The advent of DNA ancestry testing motivated a burst of human activities that constitute a scientific-technological-industrial-personal-social movement of immense scale, infused with epistemological and ethical questions of great and important variety. This movement has motivated many discourses in the social sciences, with study subjects ranging from the language usage of geneticists, to moral conundrums faced by test-takers, to potential ramifications in global structures of political power. At the same time, and especially in recent decades, the discourses of the comparative humanities have included with increasing frequency and urgency research and theorization about concepts and consequences of human social identities, alongside …
This Is Just A Phase : The Impact Of Population Structure On Haplotype Phasing And Linkage Disequilibrium Measures At Functional Genetic Sites., Roxanne Kaaren Leiter
This Is Just A Phase : The Impact Of Population Structure On Haplotype Phasing And Linkage Disequilibrium Measures At Functional Genetic Sites., Roxanne Kaaren Leiter
Electronic Theses and Dissertations
The block-like structure of the human genome has been the subject of many scientific papers and is of practical significance in large-scale genome-wide association studies. How stringent haplotype block boundaries are within and between populations has been the subject of ongoing debate within human population genetics. This thesis will contribute to the description of universal and population-specific haplotype blocks at functional sites, namely across the IL-10 gene family (including IL-10, IL-19, IL-20 and IL-24), which is involved in a number of immune system processes, and MAPKAP-K2, an adjacent and functionally significant kinase gene. Beyond the description of blocks across these …
Effect Of Migration, Carrying Capacity, And Fecundity On The Formation Of Clinal Patterns During Range Expansions., Neha J. Angal
Effect Of Migration, Carrying Capacity, And Fecundity On The Formation Of Clinal Patterns During Range Expansions., Neha J. Angal
Electronic Theses and Dissertations
Range expansions, empirically and in simulations, lead to clinal patterns of genetic diversity. Clines are often used as spatial markers of past migrations. This study investigated the effects of migration, growth, and carrying capacities on clinal patterns during range expansions, using forward-time simulations in Nemo. Initial results show, in the absence of prior population structure, range expansions result in a loss of diversity strongly affected by migration, growth, and carrying capacity. This loss of diversity did not persist to the final generation, corresponding to 10,000 years, indicating clinal patterns are less durable than previously assumed—challenging the utility of clinal patterns …