Social and Behavioral Sciences Commons^™

Thrombin And Exercise Similarly Influence Expression Of Cell Cycle Genes In Cultured Putative Endothelial Progenitor Cells, Michael M. Lockard, Sarah Witkowski, Nathan T. Jenkins, Espen E. Spangenburg, Thomas O. Obisesan, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

Acute exercise and exercise training may influence putative endothelial progenitor cell (EPC) number and colony forming units (CFU-ECs), although the mechanisms remain unclear. This study examined the effects of in vitro thrombin supplementation and acute exercise on CFU-EC gene expression, associated with cellular proliferation and differentiation. The effect of habitual physical activity was evaluated through analysis of EPCs from chronically high- and low-active men. Participants were healthy high- and low-active men (n = 23), aged 55-80 yr. Circulating CD34+/VEGFR2+ number, CFU-ECs, plasma prothrombin fragment (F1+2), and thrombin-antithrombin III were measured at rest and after 30 min of exercise. Gene expression …