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Full-Text Articles in Social and Behavioral Sciences
Transcranial Doppler Estimation Of Cerebral Blood Flow And Cerebrovascular Conductance During Modified Rebreathing, Jurgen A.H.R. Claassen, Rong Zhang, Qi Fu, Sarah Witkowski, Benjamin D. Levine
Transcranial Doppler Estimation Of Cerebral Blood Flow And Cerebrovascular Conductance During Modified Rebreathing, Jurgen A.H.R. Claassen, Rong Zhang, Qi Fu, Sarah Witkowski, Benjamin D. Levine
Exercise and Sport Studies: Faculty Publications
Clinical transcranial Doppler assessment of cerebral vasomotor reactivity (CVMR) uses linear regression of cerebral blood flow velocity (CBFV) vs. end-tidal CO2 (PETCO2) under steady-state conditions. However, the cerebral blood flow (CBF)-PETCO2 relationship is nonlinear, even for moderate changes in CO2. Moreover, CBF is increased by increases in arterial blood pressure (ABP) during hypercapnia. We used a modified rebreathing protocol to estimate CVMR during transient breath-by-breath changes in CBFV and PETCO2. Ten healthy subjects (6 men) performed 15 s of hyperventilation followed by 5 min of rebreathing, with supplemental O2 to maintain arterial oxygen saturation constant. To minimize effects of changes …