Social and Behavioral Sciences Commons^™

Eeg Features Of Explore-Exploit Decision-Making In Alcohol Use Disorder, Ethan Campbell

Psychology ETDs

Little research has assessed explore-exploit behavior in addiction using drug cues and even fewer studies have measured the neural activity underlying these behaviors. The present study aims to explore brain mechanisms of disordered decision-making in alcohol use disorder (AUD) through electroencephalography (EEG) during performance of a novelty bandit task with alcohol imagery and using a validated computational model of explore-exploit dynamics. Individuals with AUD (n = 28) and age and sex-matched controls (n = 27) showed differences in choice behavior and showed differences in EEG activity as a function of exploratory behavior, chosen stimulus type, and explore-exploit computational …

Std Prevention: An Educational Intervention For Exotic Dancers, Maria Delurdes Dehoyos

Electronic Theses and Dissertations

The Centers for Disease Control and prevention reported nearly 2.3 million STD cases diagnosed in 2017, and the number is continuing to rise. San Antonio, Texas, is ranked third in the state of Texas with the highest STD rates and leading in the state with congenital syphilis. There is an increased risk for contracting STDs working in the sex industry. There are little to no studies pertaining to any educational interventions offered to exotic dancers to increase personal knowledge on STDs. This research has focused on an educational intervention offered by a nurse practitioner to exotic dancers in two adults-only …

Predicting Young Adults’ Intentions And Involvement In Alcohol-Influenced Aquatic Activity, Hannah L M Calverley, Lauren A. Petrass Ph.D., Jennifer D. Blitvich

International Journal of Aquatic Research and Education

Globally, alcohol consumption is a public health issue and a risk factor for drownings among young adults. While studies have identified a prominence of alcohol in youth drownings, little is known about the factors that influence young adults’ involvement in alcohol-influenced aquatic activity. The current study aimed to identify the predictors of young adults’ intention to participate, and past participation, in alcohol-influenced aquatic activity. A reliable and valid survey, informed by the Theory of Planned Behavior, was distributed to young adults (aged 18-24 years) educated in the UK and Australia. Cumulative odds ordinal logistic regressions with proportional odds were …

Pharmacokinetics And Reward-Related Behaviors Of Ethanol In Male And Female Japanese Quail (Coturnix Japonica), Shannon Eaton

Theses and Dissertations--Psychology

Ethanol is one of the most widely used and abused drugs. Problem use is associated with many different health problems and the economic burden is in the billions of dollars. Additionally, many people have difficulty controlling their ethanol consumption and about 5% of adults end up with an alcohol use disorder (AUD). Many people with an AUD often find themselves in a cycle of binge, remission, and relapse.

Following ethanol consumption ethanol enters the bloodstream from the small intestine where it gets distributed to peripheral tissues. Ethanol in the bloodstream is cleared from the system by the liver. The primary …

Alcohol_Focused Drowning Prevention Campaigns: What Do We Know And What Should We Do Now?, Hannah Calverley, Lauren Petrass, Jennifer Blitvich

International Journal of Aquatic Research and Education

Alcohol and drugs have been identified as key risk factors for youth (aged 15-24 years) and adult drownings in high-income countries (HIC). Whilst alcohol specific drowning prevention education programs have been developed and implemented, youth continue to be over-represented in drowning statistics, including those linked with alcohol. Therefore, this project aimed to: (i) review and assess all alcohol themed drowning prevention campaigns within HICs; (ii) determine whether the campaign had undergone evaluation for effectiveness; and (iii) provide recommendations to improve the effectiveness of future interventions. For each of the eighty-one HICs identified for the 2019 fiscal year, searches of peer-reviewed …

Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt

Theses and Dissertations

Alcohol use disorder (AUD) is a debilitating psychiatric illness that develops from a combination of genetic and environmental factors. While it is well documented that AUD is heritable, the shift from recreational alcohol use to abuse/dependence is poorly understood. In this dissertation, using postmortem brain tissue from individuals with alcohol dependence (AD), we profiled the genome-wide expression of circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) to better understand the impact of gene expression on the development of AUD. To achieve this, we performed two independent studies that explore transcriptome differences between AD cases and controls. The first of …

Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna

Theses and Dissertations

Widely effective treatment for alcohol use disorder is not yet available, because the exact biological mechanisms that underlie this disorder are not completely understood. One way to gain a better understanding of these mechanisms is to examine the genetic frameworks that contribute to the risk for developing this disorder. This dissertation examines genetic association data in combination with gene expression networks in the brain to identify functional groups of genes associated with alcohol consumption and dependence.

The first study took advantage of the behavioral complexity of human samples, and experimental capabilities provided by mouse models, by co-analyzing gene expression networks …

Evaluation Of Neurobiological Risk Factors For Alcohol Consumption; Convergent Evidence For Predispositional Effects Of Brain Volume, David Baranger

Arts & Sciences Electronic Theses and Dissertations

Alcohol is one of the most widely used psychoactive substances and accounts for 5% of global disease burden. The goal of the present work is to help advance efforts to both identify prognostic markers of risk, and to understand the mechanisms by which alcohol consumption impacts health. Early life stress is one of the strongest predictors of mental illness, including alcohol dependence, and has been hypothesized to impact risk via modulation of striatal reward functions and reward learning. Studies examined the effect of stress on reward learning and processing, and tested for moderation by genetic and environmental risk. Results were …

Baked And Buzzed: Investigating The Influence Of Co-Use Of Cannabis And Alcohol On White Matter Integrity In Emerging Adults, Natasha E. Wright

Theses and Dissertations

Objective: Growing evidence suggests alcohol and cannabis use independently alter neural structure and functioning, particularly during sensitive developmental time periods such as adolescence and emerging adulthood. However, there has been minimal investigation into the effects co-occurring use of these two substances, despite preliminary evidence of unique acute and psychopharmacological changes due to using alcohol and cannabis together.

Method: Data drawn from the IDEAA Consortium was utilized to assess white matter integrity as measured by FreeSurfer’s TRACULA in emerging adults (n=192; 16-27 years old). Timeline Follow-Back was used to calculate past month cannabis use, alcohol use, co-use days, binge alcohol episode, …

College Student Alcohol Use And Engagement In Prevention Programming, Alexis H. Branch, Shimona Kumar, Christina Mcgrath

Undergraduate Research Posters

Social problems and adverse consequences have been associated with risky alcohol use (Paschall et al, 2015). Personalized Normative Feedback (PNF) has been utilized to address these problems (White and Hingson, 2014) by comparing students’ alcohol use to campus or national norms (Butler et al, 2009). The current investigation sought to understand differences in alcohol use behaviors in freshmen who did and did not report completion of a personalized feedback intervention (PFI) in a diverse sample of college students from the Spit for Science (S4S) project. S4S is a campus-wide, longitudinal study on the genetic and environmental factors that contribute to …

Anxiety-Like Behaviors And C-Fos Expression In Adult Zebrafish: Effects Of Housing Conditions, Alcohol And Caffeine, Adam Douglas Collier

Dissertations

Alcohol abuse is the third largest risk factor for disease world, responsible for an estimated 3.3 million deaths each year. The concomitant ingestion of alcohol and caffeine is hypothesized to increase risk factors associated with alcohol use alone by reducing subjective effects of intoxication. The zebrafish (Danio rerio) has recently garnered attention from researchers as an effective pre-clinical in-vivo animal model in behavioral pharmacology research, largely due to small size, low-cost and ease of drug delivery. A number of studies have reported the effects of alcohol and caffeine on zebrafish behavior at a variety of doses. However, the …

The Effects Of Chronic Partial Sleep Deprivation And Chronic Voluntary Alcohol Consumption On Δfos B Accumulation, Kristian Ponder

Masters Theses, 2010-2019

The present study explores the relation between sleep restriction and alcohol use and the neural substrates that result from chronic behaviors. Accumulation of the transcription factors ΔFosB is suggested as a possible outcome of chronic behaviors, such as addiction. Sleep is discussed as possible mediating factor in the relationship between ΔFosB and chronic alcohol consumption. There were four experimental groups in this study: Control (C), Sleep Deprivation only (SD), Alcohol Exposure only (AO), and both sleep deprivation and alcohol exposure (B). Levels of ΔFosB accumulation in the Nucleus Accumbens (NAc) revealed a significant main effect of sleep deprivation, but no …

Moderate Ethanol Consumption Results In Cognitive Protection From Alzheimer’S Disease, Dementia, And Related Cognitive Decline: A Critical Review, Sean P. Coffinger

Butler Journal of Undergraduate Research

Moderate ethanol preconditioning, a result of prolonged moderate alcohol intake, serves as a protective process by staving off cognitive decline while providing neuronal protection through several mechanisms. These individual mechanisms are relatively well known, however a comprehensive and integrated conversation of ethanol’s protective tendencies is lacking from literature and the field of neuroscience. First, a review of the leading theories behind moderate ethanol preconditioning’s biological and cognitive benefits is presented, including overviews of neuroprotective, antioxidant, and neurotropic mechanisms responsible for neurological benefit. Secondly, an integrative model is presented, incorporating all research into a novel collaborative model. An additional discussion regarding …

The Effect Of Voluntary Binge Caffeine And Ethanol Coexposure On Neurobehavioral Sensitivity To Cocaine In Male C57bl/6j Mice, Brandon M. Fritz

Open Access Dissertations

Recently, the co-consumption of highly caffeinated energy drinks and alcohol has become a public health concern. Consumption of these beverages has been linked to a wide variety negative consequences including alcohol poisoning, driving under the influence, physical harm, and sexual violence. The more protracted consequences of caffeinated alcohol consumption have received very little attention, however. Some evidence suggests that individuals that frequently consume energy drinks mixed with alcohol are more likely to develop an alcohol use disorder. Interestingly, both caffeine and alcohol use alone have been linked to polydrug abuse. It is therefore of interest whether combined caffeine and alcohol …

The Role Of The Dopamine/Ecdysteroid Receptor Dopecr In Ethanol Induced Behavioral Disinhibition, Gissel Pryscilla Aranda

Open Access Theses & Dissertations

Ethanol, a main active ingredient of alcoholic beverages, exerts numerous effects on behavior through its interaction with diverse membrane and signaling molecules and effector cells. The effects include lack of motor control, behavioral disinhibition, tolerance, sensitization and addiction. In particular, behavioral disinhibition is typically associated with heavy drinking and can lead to detrimental consequences such as car accidents, violent rages, risky sexual behavior and illegal substance abuse. This research aimed to clarify the neural elements and cellular mechanisms underlying behavioral disinhibition induced by ethanol. The neurotransmitter dopamine (DA) is implicated in ethanol-induced behavioral disinhibition (Van Gaalen et al., 2006). To …

Chronic Pancreatitis, Pain, And Anxiety In An Alcohol And High Fat Mouse Model, Tiffanie Clinkinbeard

Theses and Dissertations--Gerontology

Homeodynamic space (HDS) shrinks as vulnerability increases with aging and repeated damage to the cells. HDS is lost in alcoholic pancreatitis patients due to overconsumption of alcohol, smoking, and high fat diets. Etiologically relevant animal models for study of chronic pancreatitis (CP) are needed. In order to begin filling this gap a central purpose of this dissertation research was to examine relationships between the alcohol and high fat diet (AHF) and pancreatitis with attention to hypersensitivity and anxiety-like behaviors. The AHF diet induced pancreatitis described here etiologically mimics human risk factors of AHF consumption for advancement to alcoholic CP.

In …

Behavioral And Neural Mechanisms Of Impulsive Choice, Jesse Mcclure

Doctoral Dissertations

Impulsive choice is defined as the preference for a small immediate reward over a larger delayed reward. Individual variablity in impulsive choice correlates with many socially relevant behaviors. Although forms of impulsive choice have been studied in both behavioral ecology and psychology, the exchange of knowledge between these fields is just beginning. Drawing from both of these fields will improve our research methods allowing for a more detailed understanding of this complex behavior. Existing tasks to measure impulsive choice conflate the delay and quantity of the reward. To address this, I have drawn from foraging research to establish a method …

Verbal Learning And Memory In Adolescent Cannabis Users, Alcohol Users And Non-Users, Nadia Solowij, Katy A. Jones, Megan E. Rozman, Sasha M. Davis, Joseph Ciarrochi, Patrick C. L Heaven, Dan I. Lubman, Murat Yucel

joseph Ciarrochi

Rationale Long-term heavy cannabis use can result in memory impairment. Adolescent users may be especially vulnerable to the adverse neurocognitive effects of cannabis. Objectives and methods In a cross-sectional and prospective neuropsychological study of 181 adolescents aged 16–20 (mean 18.3 years), we compared performance indices from one of the most widely used measures of learning and memory—the Rey Auditory Verbal Learning Test—between cannabis users (n=52; mean 2.4 years of use, 14 days/month, median abstinence 20.3 h), alcohol users (n=67) and non-user controls (n=62) matched for age, education and premorbid intellectual ability (assessed prospectively), and alcohol consumption for cannabis and alcohol …

Reflection Impulsivity In Adolescent Cannabis Users: A Comparison With Alcohol-Using And Non-Substance-Using Adolescents, Nadia Solowij, Katy A. Jones, Megan E. Rozman, Sasha M. Davis, Joseph Ciarrochi, Patrick C. L Heaven, Nicole Pesa, Dan I. Lubman, Murat Yucel

joseph Ciarrochi

Rationale Reflection impulsivity-a failure to gather and evaluate information before making a decision-is a critical component of risk-taking and substance use behaviours, which are highly prevalent during adolescence. Objectives and methods The Information Sampling Test was used to assess reflection impulsivity in 175 adolescents (mean age 18.3, range 16.5-20; 55% female)-48 cannabis users (2.3 years use, 10.8 days/month), 65 alcohol users, and 62 non-substance-using controls-recruited from a longitudinal cohort and from the general community and matched for education and IQ. Cannabis and alcohol users were matched on levels of alcohol consumption. Results Cannabis users sampled to the lowest degree of …

Responsible Integration Of Biological And Psychosocial Models: Comments On “Genetic Associations With Intimate Partner Violence In A Sample Of Hazardous Drinking Men In Batterer Intervention Programs”, Antonia Abbey

Psychology Faculty Research Publications

Despite research demonstrating that gene expression differs in response to social environmental circumstances, deterministic views of biology are common. Stuart and colleagues (this issue) encourage readers to think about genetic factors in the same dynamic and probabilistic manner that they consider other causes of intimate partner violence. Given that participants had co-occurring alcohol problems, future studies should evaluate how different genetic polymorphisms uniquely and synergistically contribute to heavy drinking and aggression under different socio-environmental conditions. Psychological expectancies have a powerful impact on behavior, thus extreme caution is required before labeling people as genetically predisposed to violence.

Alcohol Biomarkers As Predictive Factors Of Rearrest In High Risk Repeat Offense Drunk Drivers, Brian Charles Kay

Theses and Dissertations

Alcohol biomarkers, or naturally occurring molecules which occur in response to one's alcohol consumption, are proving to be a value tool in objectively monitoring one's alcohol consumption. Coupling this assessment tool, with advances in computing power, new and powerful predictions are becoming evermore possible. In this retrospective study, data was first collected that consisted of a sample of 249 drivers convicted of driving under the influence charge and who monitored over the course of a year by biomarker blood tests. This data was then analyzed using machine learning methods. TwoStep cluster analysis showed distinct drinking groups within the drivers who …

Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly

Peter Kelly

Objective: Premature termination from treatment is a major factor associated with poorer drug and alcohol treatment outcomes. The present study investigated client-related baseline predictors of dropout at 3 months from a faith-based 12-step residential drug treatment program. Method: Data were collected over a period of 14 months from eight residential drug and alcohol treatment programs run by The Australian Salvation Army. The final sample consisted of 618 participants, including 524 men (84.8%) and 94 women (15.2%). Predictor variables of interest were age, gender, primary drug of concern, criminal involvement, psychological distress, drug cravings, self-efficacy to abstain, spirituality, forgiveness of self …

A Hangover And A One-Night Stand: Alcohol And Risky Sexual Behaviour Among Female Students At An Australian University, Heidi Gilchrist, Kylie Smith, Christopher A. Magee, Sandra Jones

Sandra Jones

There is a growing body of research in Australia exploring the alcohol consumption behaviours of young people and the attendant health and social risks associated with excessive use of alcohol (Chikritzhs et al. 2003; Mancina-Pena & Tyson 2007). A number of studies from countries such as the United States and New Zealand indicate that university students tend to drink at riskier levels than the broader population (see for example Wechsler et al. 1994; Kypri, Stephenson & Langley 2005; Wechsler & Nelson 2008). Data from Australia are limited, although the few studies that have been conducted suggest that Australian university students …

A Pilot Study Investigating Of The Nature Of Point-Of-Sale Alcohol Promotions In Bottle Shops In A Large Australian Regional City, Sandra C. Jones, Melissa Lynch

Sandra Jones

Objective: The promotion of alcohol by retailers and media can contribute to a culture of excessive alcohol consumption, but the effect of non-advertising alcohol promotions has largely been neglected. This study sought to gather initial data on this important area.Method: An observational study of alcohol point-of-sale promotions in the Wollongong CBD area, conducted in July-August 2005.Results: We identified 17 different promotions in three categories: gift with purchase; competitions; and buy some, get some free.Conclusions: Given previous research demonstrating the relationship between increased alcohol consumption and both ownership of alcohol-related merchandise and reduced per unit price, it appears that point-of-sale promotions …

Exposure To Alcohol Advertising And Alcohol Consumption Among Australian Adolescents, Sandra C. Jones, Christopher A. Magee

Sandra Jones

Aims: Underage drinking is a major problem in Australia and may be influenced by exposure to alcohol advertising. The objective of the present study was to collect data on 12 17 year old Australian adolescents' exposure to different types of alcohol advertising and examine the association between exposure to advertising and alcohol consumption. Methods: A cross-sectional survey of 1113 adolescents aged 12 17 years recruited with a variety of methods to gain a cross-section of participants across metropolitan, regional and rural New South Wales (including independent schools, mall intercepts and online). Participants answered a series of questions assessing adolescents' exposure …

Non-Advertising Alcohol Promotions In Licensed Premises: Does The Code Of Practice Ensure Responsible Promotion Of Alcohol?, Sandra C. Jones, Melissa Lynch

Sandra Jones

Introduction and Aims. Binge drinking is a major public health issue in Australia, particularly among young people. There has been a considerable focus on alcohol advertising, among both researchers and policy makers, resulting in efforts to bring about some level of regulation of unacceptable advertising practices. However - despite the existence of a Code of Practice for Responsible Promotion of Liquor Products which provides 'a framework of practices which are considered acceptable and reasonable' for licensed premises - there are few, if any, data on the nature and extent of promotions which could arguably fall under either 'acceptable' or 'unacceptable' …

Predicting Dropout In The First 3 Months Of 12-Step Residential Drug And Alcohol Treatment In An Australian Sample, Frank P. Deane, David J. Wootton, Ching-I Hsu, Peter J. Kelly

Frank Deane

Objective: Premature termination from treatment is a major factor associated with poorer drug and alcohol treatment outcomes. The present study investigated client-related baseline predictors of dropout at 3 months from a faith-based 12-step residential drug treatment program. Method: Data were collected over a period of 14 months from eight residential drug and alcohol treatment programs run by The Australian Salvation Army. The final sample consisted of 618 participants, including 524 men (84.8%) and 94 women (15.2%). Predictor variables of interest were age, gender, primary drug of concern, criminal involvement, psychological distress, drug cravings, self-efficacy to abstain, spirituality, forgiveness of self …

Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe

Trevor Crowe

There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …

Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe

Frank Deane

There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …

Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe

Peter Kelly

There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …