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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Drd2 Polymorphisms Imparting Risk For Schizophrenia, Lauren Paish
Drd2 Polymorphisms Imparting Risk For Schizophrenia, Lauren Paish
Honors Capstone Projects - All
Schizophrenia is a disorder that affects 1% of the population and causes enormous deficits in functioning. The development of this disorder is through unclear mechanisms, yet studies suggest that genetics and dopamine processes play a major role in the manifestation of schizophrenia. This study considers the gene that encodes dopamine receptor D2 (DRD2) and how single nucleotide polymorphisms (SNPs) affect alternative splicing of the gene and the balance between the two different protein isoforms, Long (D2L) and Short (D2S). Four mutations (rs12363125 and rs2511521 from intron 5 and rs6275 and rs6277 from exon 7) were studied. Constructs were derived …
Su People, Yuhan Xu, Paula Meseroll, Kathleen Haley, Jay Cox, Jim Reilly, Carol L. Boll
Su People, Yuhan Xu, Paula Meseroll, Kathleen Haley, Jay Cox, Jim Reilly, Carol L. Boll
Syracuse University Magazine
No abstract provided.