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Full-Text Articles in Social and Behavioral Sciences
Persistent Sympathetic Activation During Chronic Antihypertensive Therapy, Qi Fu, Rong Zhang, Sarah Witkowski, Armin Arbab-Zadeh, Anand Prasad, Kazunobu Okazaki, Benjamin D. Levine
Persistent Sympathetic Activation During Chronic Antihypertensive Therapy, Qi Fu, Rong Zhang, Sarah Witkowski, Armin Arbab-Zadeh, Anand Prasad, Kazunobu Okazaki, Benjamin D. Levine
Exercise and Sport Studies: Faculty Publications
Previous studies have demonstrated that antihypertensive treatment resets baroreflex control of heart rate (HR) and increases cardiac vagal baroreflex sensitivity. However, it is uncertain whether baroreflex control of muscle sympathetic nerve activity (MSNA) also resets after treatment. We tested the hypothesis that chronic antihypertensive therapy alters baroreflex regulation of MSNA in patients with untreated moderate hypertension. Seven newly diagnosed patients with systolic blood pressure (BP) of 159 5 mm Hg (mean SE) and diastolic BP of 103 4 mm Hg were studied before and after 1 to 2 weeks ´ and 3 months (chronic) of antihypertensive treatment with losartan– hydrochlorothiazide …
Nitric Oxide Synthase Inhibition Does Not Affect Regulation Of Muscle Sympathetic Nerve Activity During Head-Up Tilt, Jian Cui, Rong Zhang, Thad E. Wilson, Sarah Witkowski, Craig G. Crandall, Benjamin D. Levine
Nitric Oxide Synthase Inhibition Does Not Affect Regulation Of Muscle Sympathetic Nerve Activity During Head-Up Tilt, Jian Cui, Rong Zhang, Thad E. Wilson, Sarah Witkowski, Craig G. Crandall, Benjamin D. Levine
Exercise and Sport Studies: Faculty Publications
To test the hypothesis that systemic inhibition of nitric oxide (NO) synthase does not alter the regulation of sympathetic outflow during head-up tilt in humans, in eight healthy subjects NO synthase was blocked by intravenous infusion of NG-monomethyl-L-arginine (L-NMMA). Blood pressure, heart rate, cardiac output, total peripheral resistance (TPR), and muscle sympathetic nerve activity (MSNA) were recorded in the supine position and during 60° head-up tilt. In the supine position, infusion of L-NMMA increased blood pressure, via increased TPR, and inhibited MSNA. However, the increase in MSNA evoked by head-up tilt during L-NMMA infusion (change in burst rate: 24 ± …