Social and Behavioral Sciences Commons^™

Differential Expression Of Hypothalamic Cart Mrna In Response To Body Weight Change Following Different Dietary Interventions, Yinghua Yu, Timothy South, Qing Wang, Xu-Feng Huang

Xu-Feng Huang

Cocaine- and amphetamine-regulated transcript (CART) peptide is widely expressed in the hypothalamus and is involved in the central regulation of energy balance. Using in situ hybridization, this study examined the roles of CART peptide in the hypothalamus of diet-induced obese (DIO) or dietresistant (DR) mice under different dietary interventions including high-fat (HF), low-fat (LF) and pairfeeding (PF) diet for 6 weeks. Pair feeding the energy intake of the DIO and DR mice was used to determine whether there is an inherent difference in baseline CART expression that may cause the DIO and DR phenotypes. The results demonstrated that CART mRNA …