Social and Behavioral Sciences Commons^™

Flavonoid Intake And Plasma Sex Steroid Hormones, Prolactin, And Sex Hormone-Binding Globulin In Premenopausal Women, You Wu, Susan E. Hankinson, Stephanie A. Smith-Warner, Molin Wang, A. Heather Eliassen

Biostatistics and Epidemiology Faculty Publications Series

Background: Flavonoids potentially exert anti-cancer effects, as suggested by their chemical structures and supported by animal studies. In observational studies, however, the association between flavonoids and breast cancer, and potential underlying mechanisms, remain unclear. Objective: To examine the relationship between flavonoid intake and sex hormone levels using timed blood samples in follicular and luteal phases in the Nurses’ Health Study II among premenopausal women. Methods: Plasma concentrations of estrogens, androgens, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), prolactin, and sex hormone-binding globulin (SHBG) were measured in samples collected between 1996 and 1999. Average flavonoid were calculated from semiquantitative food frequency questionnaires …

Incidence Of Pediatric Cannabis Exposure Among Children And Teenagers Aged 0 To 19 Years Before And After Medical Marijuana Legalization In Massachusetts, Jennifer M. Whitehill, Calla Harrington, Cheryl J. Lang, Michael Chary, Waqaas A. Bhutta, Michael D. Burns

Health Promotion and Policy Faculty Publication Series

Importance Pediatric health care contacts due to cannabis exposure increased in Colorado and Washington State after cannabis (marijuana) policies became more liberal, but evidence from other US states is limited.

Objective To document the incidence of pediatric cannabis exposure cases reported to the Regional Center for Poison Control and Prevention (RPC) before and after medical marijuana legalization (MML) in Massachusetts.

Design, Setting, and Participants Cross-sectional comparison of pediatric cannabis exposure cases 4 years before and after MML in Massachusetts. The exposure cases included those of 218 children and teenagers aged between 0 and 19 years, as reported to the RPC …

Pregnancies, Abortions, And Pregnancy Intentions: A Protocol For Modeling And Reporting Global, Regional And Country Estimates, Jonathan Marc Bearak, Anna Popinchalk, Gilda Sedgh, Bela Ganatra, Ann-Beth Moller, Özge Tunçalp, Leontine Alkema

Biostatistics and Epidemiology Faculty Publications Series

Background

Estimates of pregnancies, abortions and pregnancy intentions can help assess how effectively women and couples are able to fulfil their childbearing aspirations. Abortion incidence estimates are also a necessary foundation for research on the safety of abortions performed and the consequences of unsafe abortion. Furthermore, periodic estimates of these indicators are needed to help inform policy and programmes.

Methods

We will develop a Bayesian hierarchical times series model which estimates levels and trends in pregnancy rates, abortion rates, and percentages of pregnancies and births unintended for each five-year period between 1990 and 2019. The model will be informed by …

Identifying Metabolomic Profiles Of Insulinemic Dietary Patterns, Fred K. Tabung, Raji Balasubramanian, Liming Liang, Steven K. Clinton, Elizabeth M. Cespedes Feliciano, Joann E. Manson, Linda Van Horn, Jean Wactawski-Wende, Clary B. Clish, Edward L. Giowanucci, Kathryn M. Rexrode

Biostatistics and Epidemiology Faculty Publications Series

The food-based empirical dietary index for hyperinsulinemia (EDIH) score assesses the insulinemic potential of diet. This cross-sectional study evaluated associations between EDIH scores from food frequency questionnaires with c-peptide concentrations and with 448 metabolites, from fasting plasma samples, in multivariable linear regression analyses. Metabolites were measured with liquid chromatography tandem mass spectroscopy. Using a robust two-stage study design, discovery of metabolite associations was conducted among 1109 Women’s Health Initiative (WHI) Hormone Therapy (HT) trial participants and results replicated in an independent dataset of 810 WHI Observational Study (OS) participants. In both discovery and replication datasets, statistical significance was based on …