Social and Behavioral Sciences Commons^™

Hyperhomocysteinemia-Induced Gene Expression Changes In The Cell Types Of The Brain, Erica M. Weekman, Abigail E. Woolums, Tiffany L. Sudduth, Donna M. Wilcock

Sanders-Brown Center on Aging Faculty Publications

High plasma levels of homocysteine, termed hyperhomocysteinemia, are a risk factor for vascular cognitive impairment and dementia, which is the second leading cause of dementia. While hyperhomocysteinemia induces microhemorrhages and cognitive decline in mice, the specific effect of hyperhomocysteinemia on each cell type remains unknown. We took separate cultures of astrocytes, microglia, endothelial cells, and neuronal cells and treated each with moderate levels of homocysteine for 24, 48, 72, and 96 hr. We then determined the gene expression changes for cell-specific markers and neuroinflammatory markers including the matrix metalloproteinase 9 system. Astrocytes had decreased levels of several astrocytic end feet …

Cerebrovascular Pathology In Down Syndrome And Alzheimer Disease, Elizabeth Head, Michael J. Phelan, Eric Doran, Ronald C. Kim, Wayne W. Poon, Frederick A. Schmitt, Ira T. Lott

Sanders-Brown Center on Aging Faculty Publications

People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly, atherosclerosis and hypertension are atypical in DS with age, suggesting the lack of these vascular risk factors may be associated with reduced cerebrovascular pathology. However, because the extra copy of APP leads to increased beta-amyloid peptide (Aβ) accumulation in DS, we hypothesized that there would be more extensive and widespread cerebral amyloid angiopathy (CAA) with age in DS relative to sporadic AD. To test this hypothesis CAA, …

A New Opportunity For Memri, Ryan Cloyd, Moriel H. Vandsburger, Jose F. Abisambra

Sanders-Brown Center on Aging Faculty Publications

No abstract provided.

Retention Of Normal Glia Function By An Isoform-Selective Protein Kinase Inhibitor Drug Candidate That Modulates Cytokine Production And Cognitive Outcomes, Zhengqiu Zhou, Adam D. Bachstetter, Claudia B. Späni, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik

Sanders-Brown Center on Aging Faculty Publications

Background: Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an innovative pharmacological strategy via inhibiting the same activated target in both glia and neurons, thereby enhancing the possibility for efficacy. The highly selective, brain-penetrant p38αMAPK inhibitor MW150 attenuates cognitive dysfunction in two distinct Alzheimer's disease (AD)-relevant models and avoids the problems encountered with previous mixed-kinase inhibitor drug candidates. Therefore, it is essential that the glial effects of this CNS-active kinase inhibitor be addressed in order to anticipate future use in clinical investigations.

Methods: …

Tuning Up The Old Brain With New Tricks: Attention Training Via Neurofeedback, Yang Jiang, Reza Abiri, Xiaopeng Zhao

Sanders-Brown Center on Aging Faculty Publications

Neurofeedback (NF) is a form of biofeedback that uses real-time (RT) modulation of brain activity to enhance brain function and behavioral performance. Recent advances in Brain-Computer Interfaces (BCI) and cognitive training (CT) have provided new tools and evidence that NF improves cognitive functions, such as attention and working memory (WM), beyond what is provided by traditional CT. More published studies have demonstrated the efficacy of NF, particularly for treating attention deficit hyperactivity disorder (ADHD) in children. In contrast, there have been fewer studies done in older adults with or without cognitive impairment, with some notable exceptions. The focus of this …

Rape Myth Acceptance: A Vignette Approach, Alyssa M. Campbell

Theses and Dissertations--Family Sciences

The purpose of this study was to empirically examine the extent to which rape myth acceptance (RMA) varies according to four key contextual factors—race, the victim–perpetrator relationship, resistance strategies, and the decision to report—among those embedded within college and military cultures. Although sexual assault in a university context has been thoroughly investigated, it is typically in comparison to the general population that may not share the same high-risk elements that promote the environment for sexual assault. Therefore, comparisons of college, military, and a general population were sampled to better understand the attitudes that maintain RMA in these high risk environments. …

Body Image And Sex: How Women's Body Image Influences And Impacts Sexual Experiences, Sarah E. Christian

Theses and Dissertations--Family Sciences

Body image, the subjective view about one’s own body and how others perceive it, has been shown to have numerous impacts on women in multiple facets of their lives, including sexual experiences. This study seeks to examine the specific impact that body image has on women using sexual relationships for self-validation. Findings suggest that the more likely a woman is to perceive herself as overweight, the higher the chance that she seeks out sex in order to validate her feelings with regards to her body. Parental involvement and comments about the participant’s body were also shown with the woman seeking …

Arranged Marriage In Village & Middle Class India, Umang Khandpur

Lewis Honors College Capstone Collection

In order to ensure compatibility and future sustenance of a marriage, most people devote significant time in a preparatory phase known as dating. More time spent dating would sensibly correlate to higher marriage longevities as the partners become more acquainted with the intricacies of each other. Ironically, the countries who practice this Western ideology of marriage harbor staggering divorce-to-marriage ratios (some upwards of 60%) while those with a different concept of marriage e.g. India experience much higher marriage longevities. To illuminate this seeming paradox, multiple sources were consulted including current literature, newspaper columns, economic reports, films, television series, and personal …