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Full-Text Articles in Social and Behavioral Sciences
Latent ;Toxoplasma Gondii; Infection Moderates The Association Between The C677t Mthfr Polymorphism And Cognitive Function In U.S. Adults, Andrew Nathan Berrett
Latent ;Toxoplasma Gondii; Infection Moderates The Association Between The C677t Mthfr Polymorphism And Cognitive Function In U.S. Adults, Andrew Nathan Berrett
Theses and Dissertations
Sufficient blood concentrations of folate and the products from its metabolism arenecessary for several cellular functions. The C677T MTHFR polymorphism, present in over halfof the U.S. population, reduces the efficiency of folate metabolism and has been linked to theonset of multiple psychiatric disorders and cognitive decline. The intracellular parasiteToxoplasma gondii can infect the human brain and is associated with increased prevalence ofpsychiatric disorders and cognitive decline. In vitro studies have found that Toxoplasma gondiimay salvage unmetabolized folate from host cells. Since the C677T MTHFR polymorphism andinfection by Toxoplasma gondii both affect folate metabolism or availability, I used data fromthe third …
Latent Toxoplasma Gondii Infection Moderates The Association Between The C677t Mthfr Polymorphism And Cognitive Function In U.S. Adults, Andrew Nathan Berrett
Latent Toxoplasma Gondii Infection Moderates The Association Between The C677t Mthfr Polymorphism And Cognitive Function In U.S. Adults, Andrew Nathan Berrett
Theses and Dissertations
Sufficient blood concentrations of folate and the products from its metabolism are necessary for several cellular functions. The C677T MTHFR polymorphism, present in over half of the U.S. population, reduces the efficiency of folate metabolism and has been linked to the onset of multiple psychiatric disorders and cognitive decline. The intracellular parasite Toxoplasma gondii can infect the human brain and is associated with increased prevalence of psychiatric disorders and cognitive decline. In vitro studies have found that Toxoplasma gondii may salvage unmetabolized folate from host cells. Since the C677T MTHFR polymorphism and infection by Toxoplasma gondii both affect folate metabolism …
Association Between Latent Toxoplasma Gondii Infection And Alzheimer's Disease, Cynthia Elizabeth Wyman
Association Between Latent Toxoplasma Gondii Infection And Alzheimer's Disease, Cynthia Elizabeth Wyman
Theses and Dissertations
Introduction: Many studies have found an association between Toxoplasma gondii seropositivity and behavioral and cognitive changes in animal models and in humans. In addition, early findings have suggested an association between T. gondii seropositivity and Alzheimer's disease (AD). We sought to determine whether there is an association between T. gondii seropositivity and AD as well as cognitive functioning (including memory, working memory, processing speed, language functioning, executive functioning) in a large, well-characterized sample of subjects with AD and matched controls without dementia. Method: Using ELISA assays, we determined anti-T. gondii IgG antibody titers in 114 control subjects and in …
Association Between Latent Toxoplasma Gondii Infection And Alzheimer's Disease, Cynthia Elizabeth Wyman
Association Between Latent Toxoplasma Gondii Infection And Alzheimer's Disease, Cynthia Elizabeth Wyman
Theses and Dissertations
Introduction: Many studies have found an association between Toxoplasma gondii seropositivity and behavioral and cognitive changes in animal models and in humans. In addition, early findings have suggested an association between T. gondii seropositivity and Alzheimer's disease (AD). We sought to determine whether there is an association between T. gondii seropositivity and AD as well as cognitive functioning (including memory, working memory, processing speed, language functioning, executive functioning) in a large, well-characterized sample of subjects with AD and matched controls without dementia. Method: Using ELISA assays, we determined anti-T. gondii IgG antibody titers in 114 control subjects and in 105 …