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Synthesis And Antibacterial Studies Of Some 2-Furanthiocarboxyhydrazones, Xiaorong Li, Zoumin Sun, James C. Chang
Synthesis And Antibacterial Studies Of Some 2-Furanthiocarboxyhydrazones, Xiaorong Li, Zoumin Sun, James C. Chang
Journal of the Iowa Academy of Science: JIAS
Seven 2-furanthiocarboxyhydrazones were prepared, 5-nitro-furaldehyde-2-furanthiocarboxyhydrazone from the reaction of 2-furanthiocarboxyhydrazide with 5-nitro-2-furaldiacetate and the others from the condensation of 2-furanthiocarboxyhydrazide with aldehydes: 2- furaldehyde, benzaldehyde, p-hydroxybenzaldehyde, o-methoxybenzaldehyde, o-vanillin, and salicylaldehyde. The seven 2-furanthiocarboxyhydrazones were tested for their antibacterial activities against Staphyloccocus aureus and Bacillus subtilis. 5-Nitro-2-furaldehyde-2- furanthiocarboxyhydrazone was found to display the strongest bacterotoxicity.