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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Alternations Of Nmda And Gabab Receptor Function In Development: A Potential Animal Model Of Schizophrenia, Monica Bolton
Alternations Of Nmda And Gabab Receptor Function In Development: A Potential Animal Model Of Schizophrenia, Monica Bolton
UNLV Theses, Dissertations, Professional Papers, and Capstones
Schizophrenia is a debilitating mental disorder that affects up to 3% of the world population. The behavioral symptoms are categorized into positive and negative symptoms, which appear during late adolescence/early adulthood. Unfortunately, the underlying cellular and molecular mechanisms of the disease are poorly understood. Several hypotheses exist to explain mechanisms contributing to these behavioral alterations. One model proposes that a reduced function of the NMDA glutamate receptor on specific GABAergic interneurons may be responsible for deficits in schizophrenia. Post-mortem investigations provide evidence of reductions in both glutamate and GABA-related proteins in patients with schizophrenia. Further, GABAergic interneurons that are activated …
An Acute Inflammatory Response In A Diabetic Alzheimer’S Disease Model, Krystal Courtney D. Belmonte, Jefferson Kinney
An Acute Inflammatory Response In A Diabetic Alzheimer’S Disease Model, Krystal Courtney D. Belmonte, Jefferson Kinney
McNair Poster Presentations
Alzheimer’s disease (AD) is the most common form of dementia, accounting for 50 to 80 percent of all dementia cases. This neurodegenerative disease leads to neuronal death and tissue loss in the brain, resulting in the slow deterioration of memory, thinking skills, and eventually even the ability perform daily tasks. While it is not a normal part of aging, AD is mostly diagnosed in people over the age of 65; thus, the main risk factor for Alzheimer’s disease is increased age, though it is most likely other additional factors also contribute (Heese & Akatsu, 2006). Neuropathological hallmarks of AD include …
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
Ketamine Induced Deficits In Working Memory With Relevance To Schizophrenia, Michael A. Langhardt, Jefferson Kinney
McNair Poster Presentations
Schizophrenia is a chronic debilitating brain disorder, which affects approximately one percent of the adult population worldwide. The symptoms of schizophrenia are commonly divided into three broad classes: positive symptoms, negative symptoms, and cognitive disturbances (Kay, et al., 1987). The positive symptoms of schizophrenia include hallucinations, delusions, and disorganized thinking, while the negative symptoms include affective flattening, social withdrawal, and an inability to plan and carry out future activities. The cognitive disturbances exhibited in schizophrenia include deficits in spatial reference and working memory as well as difficulties with focus and attention (Lewis et. al., 2007). Several models have been proposed …