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Biological and Physical Anthropology

University of Louisville

Electronic Theses and Dissertations

Articles 1 - 6 of 6

Full-Text Articles in Social and Behavioral Sciences

Combating Frailty: Application Of A Modified Skeletal Frailty Index In Modern Military And Civilian Populations., Emily M. Frazier May 2022

Combating Frailty: Application Of A Modified Skeletal Frailty Index In Modern Military And Civilian Populations., Emily M. Frazier

Electronic Theses and Dissertations

Conceptualizing, quantifying, and evaluating frailty in human skeletal remains is critical to understanding and interpreting physiological health and stress among past populations. While many researchers focus on frailty in bioarchaeological samples, developing models for mortality risk and individual- and population-specific indices of stress, no current methods directly address frailty in forensic contexts. This study considers the applicability of a modified index for assessing frailty in forensic anthropology by comparing distributions of 8 biomarkers of stress (linear enamel hypoplasia; periodontal disease; caries; osteoarthritis; intervertebral disc disease; rotator cuff disorder; antemortem fracture; and surgical procedure) using the original skeletal frailty index (SFI) …

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"When The Voices Of Children Are Heard": Evaluating The Biological Effects Of Socioeconomic Status On Children In Postmedieval London., Ashley R. Ezzo Aug 2021

"When The Voices Of Children Are Heard": Evaluating The Biological Effects Of Socioeconomic Status On Children In Postmedieval London., Ashley R. Ezzo

Electronic Theses and Dissertations

As the most vulnerable members of society, children (and their treatment) may reveal important sociocultural and socioeconomic praxes throughout human history. During the Postmedieval period, children, especially low socioeconomic status (SES) individuals, participated in the workforce. By examining the demographic distributions and paleopathological profiles of juvenile skeletal remains from high SES (St. Bride’s Crypt and Chelsea Old Church) and low SES (St. Bride’s Lower and Crossbones) Postmedieval (1700-1850 CE) London cemeteries, we can better understand how SES impacted the biological health and mortality of children. While results indicated higher mortality risk associated with low SES circumstances, most differences in pathological …

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Experimental Immunology And The Potential For Osteopathological Reconstructions : Pursuing An Experimental Foundation For The Skeletal Inflammatory Index., Megan Elizabeth Duncanson May 2019

Experimental Immunology And The Potential For Osteopathological Reconstructions : Pursuing An Experimental Foundation For The Skeletal Inflammatory Index., Megan Elizabeth Duncanson

Electronic Theses and Dissertations

Individuals who mount a strong inflammatory response may produce a shift in the systemic levels of inflammatory mediators, which may lead to a potential hyper-inflammatory phenotype (HIP). Systemic inflammation can increase severity in local inflammatory processes detected in bone lesions. This thesis investigated in vitro if human immune cells pre-treated with inflammatory inducers would affect the inflammatory response against Porphyromonas gingivalis or Staphylococcus aureus (both associated with osteological lesions). We exposed human peripheral blood mononuclear cells to bacterial lysates, or pro-inflammatory cytokines. Sequentially, we exposed the same culture to either P. gingivalis or S. aureus. The final expression of …

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This Is Just A Phase : The Impact Of Population Structure On Haplotype Phasing And Linkage Disequilibrium Measures At Functional Genetic Sites., Roxanne Kaaren Leiter Dec 2017

This Is Just A Phase : The Impact Of Population Structure On Haplotype Phasing And Linkage Disequilibrium Measures At Functional Genetic Sites., Roxanne Kaaren Leiter

Electronic Theses and Dissertations

The block-like structure of the human genome has been the subject of many scientific papers and is of practical significance in large-scale genome-wide association studies. How stringent haplotype block boundaries are within and between populations has been the subject of ongoing debate within human population genetics. This thesis will contribute to the description of universal and population-specific haplotype blocks at functional sites, namely across the IL-10 gene family (including IL-10, IL-19, IL-20 and IL-24), which is involved in a number of immune system processes, and MAPKAP-K2, an adjacent and functionally significant kinase gene. Beyond the description of blocks across these …

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Detecting Evidence Of Systemic Inflammation From Osteological Markers In The Indian Knoll Population Of Ohio County, Kentucky., Krysta Wilham Dec 2016

Detecting Evidence Of Systemic Inflammation From Osteological Markers In The Indian Knoll Population Of Ohio County, Kentucky., Krysta Wilham

Electronic Theses and Dissertations

Indian Knoll is an Archaic shell midden site located in the Green River region of west-central Kentucky, and was excavated twice in the first half of the 20th century. While Indian Knoll has been the subject of frequent bioarchaeological studies, the present study presents an osteological analysis of the relationships between skeletal markers commonly associated with local inflammatory processes, and that have the potential to be used as proxies for systemic inflammation. The analysis revealed a significant positive association in the presence of periodontal disease (PD) and periosteal lesions (PL), suggesting a potential underlying hyper-inflammatory status or phenotype. These …

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Effect Of Migration, Carrying Capacity, And Fecundity On The Formation Of Clinal Patterns During Range Expansions., Neha J. Angal Aug 2016

Effect Of Migration, Carrying Capacity, And Fecundity On The Formation Of Clinal Patterns During Range Expansions., Neha J. Angal

Electronic Theses and Dissertations

Range expansions, empirically and in simulations, lead to clinal patterns of genetic diversity. Clines are often used as spatial markers of past migrations. This study investigated the effects of migration, growth, and carrying capacities on clinal patterns during range expansions, using forward-time simulations in Nemo. Initial results show, in the absence of prior population structure, range expansions result in a loss of diversity strongly affected by migration, growth, and carrying capacity. This loss of diversity did not persist to the final generation, corresponding to 10,000 years, indicating clinal patterns are less durable than previously assumed—challenging the utility of clinal patterns …

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