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Rack1 Facilitates Efficient Translation Of Viral And Cellular Iress, Natasha Permaul

Anthropology

Ribosomes, the cellular machinery that translates mRNA sequences into protein sequences, are surprisingly heterogeneous molecules. More and more ribosomal proteins have been shown to facilitate translation of mRNA subsets. These mRNA subsets include mRNAs that can initiate translation using non-canonical pathways, for example using an internal ribosome entry site (IRES). IRESs are RNA structures that facilitate translation with fewer translation initiation factors than are required for canonical cap-dependent translation initiation. The ribosomal protein Receptor for Activated C Kinase 1 (RACK1) has been previously shown to be required for translation of the hepatitis C virus (HCV) IRES, but not required for …