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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice, Brandon L. Oliver
Serotonin 1b/1a Receptor Modulation On Behavioral Flexibility In C57bl/6j Mice, Brandon L. Oliver
Electronic Theses, Projects, and Dissertations
Pharmacological activation of the 5-HT1B and 1A receptors has been implicated in OCD-like behaviors in rodents such as increased perseverative circling, checking behaviors, and locomotor stereotypy. However, little is understood about the effects of 5-HT1B and 1A receptor activation on behavioral inflexibility, a common symptom associated with OCD. The present study utilized the 5-HT1B/1A receptor agonist RU24969 at 0.01, 0.1, and 1.0 mg/kg to test three hypotheses. The first hypothesis predicted RU24969 would lead to a dose-dependent impairment on behavioral flexibility in C57BL/6J mice. It was also predicted that male C57BL/6J mice would be more inflexible than female C57BL/6J mice …
Effects Of Neonatal Ethanol Exposure In Normal And Dopamine Deficient Rats, Jessica Luz Razo
Effects Of Neonatal Ethanol Exposure In Normal And Dopamine Deficient Rats, Jessica Luz Razo
Electronic Theses, Projects, and Dissertations
Attention deficit hyperactivity disorder (ADHD) is a common developmental disorder characterized by impulsivity, inattention, and hyperactivity. In rodents, neonatal 6-OHDA lesions is an established model of ADHD because it produces symptoms of hyperactivity and cognitive deficits that improve following psychostimulant treatment. Recently, early alcohol exposure in rodents has also been suggested as a model of ADHD due to the high prevalence of ADHD in children exposed prenatally to alcohol. However, children exposed to prenatal alcohol differ in symptoms from children with idiopathic ADHD, suggesting that ADHD caused by prenatal alcohol exposure may be a special subtype of ADHD or a …