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Full-Text Articles in Social and Behavioral Sciences
Long-Term Effects Of Increased Dietary Polyunsaturated Fat From Walnuts On Metabolic Parameters In Type Ii Diabetes, Cassandra Quick, Marijka Batterham, Linda Tapsell, Lynda Gillen, Karen Charlton, Sze Yen Tan, Grigorijs Teuss, Sayne Mam Dalton
Long-Term Effects Of Increased Dietary Polyunsaturated Fat From Walnuts On Metabolic Parameters In Type Ii Diabetes, Cassandra Quick, Marijka Batterham, Linda Tapsell, Lynda Gillen, Karen Charlton, Sze Yen Tan, Grigorijs Teuss, Sayne Mam Dalton
Karen E. Charlton
Background/Objectives: Most dietary interventions have metabolic effects in the short term, but long-term effects may require dietary fat changes to influence body composition and insulin action. This study assessed the effect of sustained high polyunsaturated fatty acids (PUFA) intake through walnut consumption on metabolic outcomes in type II diabetes.Subjects/Methods: Fifty overweight adults with non-insulin-treated diabetes (mean age 54±8.7 years) were randomized to receive low-fat dietary advice ±30 g per day walnuts targeting weight maintenance (around 2000 kcal, 30% fat) for 1 year. Differences between groups were assessed by changes in anthropometric values (body weight, body fat, visceral adipose tissue) and …
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Xu-Feng Huang
Antipsychotic drugs have various neuropharmacological properties as a result of their structural diversity. Despite their therapeutic benefits, most of the prescribed atypical antipsychotics can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases. Among the developed atypical antipsychotic agents, tetracyclic dibenzodiazepine and thienobenzodiazepine compounds, particularly clozapine and olanzapine, are associated with the greatest weight gain and metabolic disturbances. However, the unique chemical structure of these compounds causes the low risk of side effects reported for typical antipsychotics (e.g. extrapyramidal symptoms and tardive dyskinesia). This report reviews the recent discovery of the potential role of the …