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Full-Text Articles in Social and Behavioral Sciences
Neuronal Effects Of Cocaine In An Animal Model Of Social Stress: Analysis Of Neuronal Recordings, Eboni Eddins
Neuronal Effects Of Cocaine In An Animal Model Of Social Stress: Analysis Of Neuronal Recordings, Eboni Eddins
Honors Theses
Studies that use Intermittent (episodic) Social Defeat (ISD) in rats demonstrate that ISD increases cocaine-self administration several weeks after the end of the adverse experience and suggest that a history of social stress makes individuals more vulnerable to substance abuse in the long term. The medial prefrontal cortex (mPFC) plays a key role in regulating drug-seeking behavior. The present study investigates whether ISD enhances the response of mPFC neurons to cocaine. Male Long Evans rats (3-4 months) were implanted with electrode arrays in the mPFC (prelimbic area) and divided into two groups (Control, n= 4; Stress, n= 4). They were …