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Full-Text Articles in Social and Behavioral Sciences
Neuronal Effects Of Cocaine In An Animal Model Of Social Stress: Analysis Of Neuronal Recordings, Eboni Eddins
Neuronal Effects Of Cocaine In An Animal Model Of Social Stress: Analysis Of Neuronal Recordings, Eboni Eddins
Honors Theses
Studies that use Intermittent (episodic) Social Defeat (ISD) in rats demonstrate that ISD increases cocaine-self administration several weeks after the end of the adverse experience and suggest that a history of social stress makes individuals more vulnerable to substance abuse in the long term. The medial prefrontal cortex (mPFC) plays a key role in regulating drug-seeking behavior. The present study investigates whether ISD enhances the response of mPFC neurons to cocaine. Male Long Evans rats (3-4 months) were implanted with electrode arrays in the mPFC (prelimbic area) and divided into two groups (Control, n= 4; Stress, n= 4). They were …
Analysis Of Multigenerational Behavioral Effects Of Dietary Benzo[A]Pyrene Exposure In Adult Zebrafish, Mary Beth Gillespie
Analysis Of Multigenerational Behavioral Effects Of Dietary Benzo[A]Pyrene Exposure In Adult Zebrafish, Mary Beth Gillespie
Honors Theses
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon that is linked to negative reproductive and developmental effects in humans and animals. Because BaP is carcinogenic, and its continued presence in the environment allows it to be inhaled and ingested, better understanding of the effects of BaP is needed. To determine the behavioral effects of BaP exposure, zebrafish were used as a model. Wild-type zebrafish (5D) underwent two separate 21-day dietary exposures to 2.5 and 25 μg BaP/g fish to compare how BaP exposure affects locomotor activity. Following the dietary exposure, fish were mated to obtain and raise the F1 generation to …