Social and Behavioral Sciences Commons^™

Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee

Electronic Theses and Dissertations

We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …

The Intersection Of Aging And Pet Guardianship: Influences Of Health And Social Support, Ranell L. Mueller, Elizabeth G. Hunter

People and Animals: The International Journal of Research and Practice

Studies of the human-animal bond show many positive health effects for pet guardians including a sense of companionship, reduced depression and loneliness, and higher activity levels, yet few studies have examined factors such as how the pet guardians’ health, age, and social networks influence their relationship with and ability to care for their pet. These health factors may affect the ability of older adults to care for their pets, therefore inhibiting them from reaping positive benefits associated with pet guardianship. This qualitative study involved 21 in-depth interviews with older adults, aged 60+, who were pet guardians. Four themes emerged from …

One Year Change In Cognitive Function In Male And Female Common Marmosets (Callithrix Jacchus), Brianna Healey

Masters Theses

Long term cognitive studies in humans and nonhuman primates such as macaques are difficult because of their long lifespan. The common marmoset (Callithrix jacchus) is a non-human primate who shares with humans many features characteristic of primates, including a complex brain and cognitive function. They also have a short lifespan (~10 years) that makes them a great model in studies of cognitive aging. This study focuses on the rate of decline in cognitive function in male and female marmosets based on performance on reversal learning tasks over 2 years of testing.

We found that marmosets improved their overall …

Effect Of Maternal Age On Offspring Social Behaviour In Drosophila Melanogaster, Shirley Long

2016 Undergraduate Awards

Aging can be defined as the natural and progressive decline in physiological functioning leading to increased risk for disease and death. Although the effects of age are well characterised, much less work has been done to study whether these detrimental changes can be transmitted to offspring. Advanced parental age has been correlated with higher incidence of neuropsychiatric disorders such as autism in children. As average maternal age increases in North America, it is becoming increasingly relevant to study the effects of maternal and paternal age on offspring social behaviour. We hypothesize that advanced maternal age in Drosophila melanogaster will affect …

Effects Of 17Β-Estradiol On Learning And Memory And Strategy Use During A Hole Board Spatial Navigation Task In Aged Male Rats, Megan Berthiaume

Seton Hall University Dissertations and Theses (ETDs)

Treatment with 17β- estradiol has been shown to ameliorate age related deficits in spatial learning and memory as well as to promote the use of an allocentric strategy during spatial navigation. While the majority of research using 17β- estradiol has been done using females rodents, there have been studies showing an improvement in spatial learning and memory and promoted use of allocentric strategies in spatial navigation in males as well. In males testosterone (T) is metabolized into estradiol by aromatase. As circulating levels of T decline with aging there is less available T to be metabolized into estradiol. The current …

The Canine Sand Maze: An Appetitive Spatial Memory Paradigm Sensitive To Age-Related Change In Dogs, Hannah Salvin, Paul D. Mcgreevy, Perminder S. Sachdev, Michael Valenzuela

Spatial Cognition Collection

Aged dogs exhibit a spectrum of cognitive abilities including a syndrome similar to Alzheimer's disease. A major impediment to research so far has been the lack of a quick and accurate test of visuospatial memory appropriate for community-based animals. We therefore report on the development and validation of the Canine Sand Maze. A 4.5-m-diameter circular pool was filled with a sand and powdered food reward mix to a depth of 10 cm. Dogs were given 4 habituation and 16 learning trials which alternated a food reward being half (control trials) or fully-buried (acquisition trials) in a fixed location. After a …