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Articles 1 - 7 of 7
Full-Text Articles in Social and Behavioral Sciences
Systematic Reviews Of Animal Experiments Demonstrate Poor Human Clinical And Toxicological Utility, Andrew Knight
Systematic Reviews Of Animal Experiments Demonstrate Poor Human Clinical And Toxicological Utility, Andrew Knight
Experimentation Collection
The assumption that animal models are reasonably predictive of human outcomes provides the basis for their widespread use in toxicity testing and in biomedical research aimed at developing cures for human diseases. To investigate the validity of this assumption, the comprehensive Scopus biomedical bibliographic databases were searched for published systematic reviews of the human clinical or toxicological utility of animal experiments. In 20 reviews in which clinical utility was examined, the authors concluded that animal models were either significantly useful in contributing to the development of clinical interventions, or were substantially consistent with clinical outcomes, in only two cases, one …
Animal Research: A Moral Science, Bernard E. Rollin
Animal Research: A Moral Science, Bernard E. Rollin
Experimentation Collection
No abstract provided.
Overcoming Ideology: Why It Is Necessary To Create A Culture In Which The Ethical Review Of Protocols Can Flourish, Bernard E. Rollin
Overcoming Ideology: Why It Is Necessary To Create A Culture In Which The Ethical Review Of Protocols Can Flourish, Bernard E. Rollin
Experimentation Collection
My objective in this commentary is to describe and discuss a major threat to the continued thriving of science in our society, which is all the more insidious because it is largely unrecognized by those in the scientific community who are in a position to rectify the problem. Astute people in that community are well aware of many threats to science that include but are not limited to the following: appalling public scientific illiteracy; the unfortunate resurgence of “magic thinking”—reflected in turn in the reappearance of Creationism, which is hostile to evolution—and the billions of dollars spent on evidentially baseless …
Chimpanzee Research: An Examination Of Its Contribution To Biomedical Knowledge And Efficacy In Combating Human Diseases, Jarrod Bailey, Jonathan Balcombe, Theodora Capaldo
Chimpanzee Research: An Examination Of Its Contribution To Biomedical Knowledge And Efficacy In Combating Human Diseases, Jarrod Bailey, Jonathan Balcombe, Theodora Capaldo
Experimentation Collection
Research on captive chimpanzees incurs considerable animal welfare, ethical and financial costs. Advocates of such research claim these costs are outweighed by substantial advancements in biomedical knowledge, and that the genetic similarity of chimpanzees to humans enables the former to make critical contributions to preventing, diagnosing and combating human diseases. To assess these claims, we examined the disciplines investigated in 749 studies of captive chimpanzees published from 1995-2004 inclusive, and subjected 95 randomly selected papers to a detailed citation analysis:
49.5% (47/95) of papers had not been cited at the time of this study; 38.5% (34/95) were cited by 116 …
The Poor Contribution Of Chimpanzee Experiments To Biomedical Progress, Andrew Knight
The Poor Contribution Of Chimpanzee Experiments To Biomedical Progress, Andrew Knight
Experimentation Collection
Biomedical research on captive chimpanzees incurs substantial nonhuman animal welfare, ethical, and financial costs that advocates claim result in substantial advancements in biomedical knowledge. However, demonstrating minimal contribution toward the advancement of biomedical knowledge generally, subsequent papers did not cite 49.5% (47/95), of 95 experiments randomly selected from a population of 749 published worldwide between 1995 and 2004. Only 14.7% (14/95) were cited by 27 papers that abstracts indicated described well-developed methods for combating human diseases. However, detailed examination of these medical papers revealed that in vitro studies, human clinical and epidemiological studies, molecular assays and methods, and genomic studies …
Of Mice And Men, Bernard E. Rollin
A Holistic Approach To Taking Research Animal Suffering Seriously, Martin Stephens, Kathleen Conlee
A Holistic Approach To Taking Research Animal Suffering Seriously, Martin Stephens, Kathleen Conlee
Experimentation Collection
It is widely agreed, and often legally required, that distress and pain in research animals should be minimized--for the sake of animal welfare, ethical obligation, and public concern, as well as scientific quality. As testimony to the importance of distress and pain to stakeholders interested in research animals, many countries compile and publish annual statistics documenting overall patterns and trends on distress and pain in research animals.
We argue for a holistic approach to minimizing research animal suffering, with all relevant parties sharing in this responsibility. Researchers, laboratory personnel, oversight committees, and facility administrators are central to day-to-day animal care. …