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Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
Deepcon-Pre: Improved Protein Contact Map Prediction Using Inverse Covariance And Deep Residual Networks, Nachammai Palaniappan
Deepcon-Pre: Improved Protein Contact Map Prediction Using Inverse Covariance And Deep Residual Networks, Nachammai Palaniappan
Theses
As with most domains where machine learning methods are applied, correct feature engineering is critical when developing deep learning algorithms for solving the protein folding problem. Unlike the domains such as computer vision and natural language processing, feature engineering is not rigorously studied towards solving the protein folding problem. A recent research has highlighted that input features known as precision matrix are most informative for predicting inter-residue contact map, the key for building three-dimensional models. In this work, we study the significance of the precision matrix feature when very deep residual networks are trained. Using a standard dataset of 3456 …
Protein Inter-Residue Distance Prediction Using Residual And Capsule Networks, Andrew Dillon
Protein Inter-Residue Distance Prediction Using Residual And Capsule Networks, Andrew Dillon
Theses
The protein folding problem, also known as protein structure prediction, is the task of building three-dimensional protein models given their one-dimensional amino acid sequence. New methods that have been successfully used in the most recent CASP challenge have demonstrated that predicting a protein's inter-residue distances is key to solving this problem. Various deep learning algorithms including fully convolutional neural networks and residual networks have been developed to solve the distance prediction problem. In this work, we develop a hybrid method based on residual networks and capsule networks. We demonstrate that our method can predict distances more accurately than the algorithms …
Deep Morphological Neural Networks, Yucong Shen
Deep Morphological Neural Networks, Yucong Shen
Theses
Mathematical morphology is a theory and technique applied to collect features like geometric and topological structures in digital images. Determining suitable morphological operations and structuring elements for a give purpose is a cumbersome and time-consuming task. In this paper, morphological neural networks are proposed to address this problem. Serving as a non-linear feature extracting layers in deep learning frameworks, the efficiency of the proposed morphological layer is confirmed analytically and empirically. With a known target, a single-filter morphological layer learns the structuring element correctly, and an adaptive layer can automatically select appropriate morphological operations. For high level applications, the proposed …