Physical Sciences and Mathematics Commons^™

Integration Over Curves And Surfaces Defined By The Closest Point Mapping, Catherine Kublik, Richard Tsai

Mathematics Faculty Publications

We propose a new formulation for integrating over smooth curves and surfaces that are described by their closest point mappings. Our method is designed for curves and surfaces that are not defined by any explicit parameterization and is intended to be used in combination with level set techniques. However, contrary to the common practice with level set methods, the volume integrals derived from our formulation coincide exactly with the surface or line integrals that one wishes to compute. We study various aspects of this formulation and provide a geometric interpretation of this formulation in terms of the singular values of …

Effects Of Cell Cycle Noise On Excitable Gene Circuits, Alan Veliz-Cuba, Chinmaya Gupta, Matthew R. Bennett, Krešimir Josić, William Ott

Mathematics Faculty Publications

We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect intensifies in the presence of transcriptional delay. We explain this concentration effect with a three-states stochastic model. For genetic oscillators, we quantify the temporal correlations between daughter cells induced by cell division. Temporal correlations must be captured properly in order to accurately quantify noise sources within gene networks.

Convolutions And Green’S Functions For Two Families Of Boundary Value Problems For Fractional Differential Equations, Paul W. Eloe, Jeffrey T. Neugebauer

Mathematics Faculty Publications

We consider families of two-point boundary value problems for fractional differential equations where the fractional derivative is assumed to be the Riemann-Liouville fractional derivative. The problems considered are such that appropriate differential operators commute and the problems can be constructed as nested boundary value problems for lower order fractional differential equations. Green's functions are then constructed as convolutions of lower order Green's functions. Comparison theorems are known for the Green's functions for the lower order problems and so, we obtain analogous comparison theorems for the two families of higher order equations considered here. We also pose a related open question …

Identification Of Control Targets In Boolean Molecular Network Models Via Computational Algebra, David Murrugarra, Alan Veliz-Cuba, Boris Aguilar, Reinhard Laubenbacher

Mathematics Faculty Publications

Many problems in biomedicine and other areas of the life sciences can be characterized as control problems, with the goal of finding strategies to change a disease or otherwise undesirable state of a biological system into another, more desirable, state through an intervention, such as a drug or other therapeutic treatment. The identification of such strategies is typically based on a mathematical model of the process to be altered through targeted control inputs. This paper focuses on processes at the molecular level that determine the state of an individual cell, involving signaling or gene regulation. The mathematical model type considered …

Theorems On Boundedness Of Solutions To Stochastic Delay Differential Equations, Youssef Raffoul, Dan Ren

Mathematics Faculty Publications

In this report, we provide general theorems about boundedness or bounded in probability of solutions to nonlinear delay stochastic differential systems. Our analysis is based on the successful construction of suitable Lyapunov functionals. We offer several examples as application of our theorems.

Optimal Control Analysis Of Ebola Disease With Control Strategies Of Quarantine And Vaccination, Muhammad Dure Ahmad, Muhammad Usman, Adnan Khan, Mudassar Imran

Mathematics Faculty Publications

The 2014 Ebola epidemic is the largest in history, affecting multiple countries in West Africa. Some isolated cases were also observed in other regions of the world.

Upper And Lower Solution Method For Boundary Value Problems At Resonance, Samerah Al Mosa, Paul W. Eloe

Mathematics Faculty Publications

We consider two simple boundary value problems at resonance for an ordinary differential equation. Employing a shift argument, a regular fixed point operator is constructed. We employ the monotone method coupled with a method of upper and lower solutions and obtain sufficient conditions for the existence of solutions of boundary value problems at resonance for nonlinear boundary value problems. Three applications are presented in which explicit upper solutions and lower solutions are exhibited for the first boundary value problem. Two applications are presented for the second boundary value problem. Of interest, the upper and lower solutions are easily and explicitly …

Uniform Stability In Nonlinear Infinite Delay Volterra Integro-Differential Equations Using Lyapunov Functionals, Youssef Raffoul, Habib Rai

Mathematics Faculty Publications

In [10] the first author used Lyapunov functionals and studied the exponential stability of the zero solution of nite delay Volterra Integro-dierential equation. In this paper, we use modified version of the Lyapunov functional that were used in [10] to obtain criterion for the stability of the zero solution of the infinite delay nonlinear Volterra integro-dierential equation

x′(t) = Px(t) + ^t∫ _−∞ C(t, s)g(x(s))ds.

Asymptotically Periodic Solutions Of Volterra Integral Equations, Muhammad Islam

Mathematics Faculty Publications

We study the existence of asymptotically periodic solutions of a nonlinear Volterra integral equation. In the process, we obtain the existence of periodic solutions of an associated nonlinear integral equation with infinite delay. Schauder's fixed point theorem is used in the analysis.

Smallest Eigenvalues For A Right Focal Boundary Value Problem, Paul W. Eloe, Jeffrey T. Neugebauer

Mathematics Faculty Publications

We establish the existence of smallest eigenvalues for the fractional linear boundary value problems D^α₀₊u+λ₁p(t)u = 0 and D^α₀₊u+λ₂q(t)u = 0, 0

Existence Of Periodic Solutions For A Quantum Volterra Equation, Muhammad Islam, Jeffrey T. Neugebauer

Mathematics Faculty Publications

The objective of this paper is to study the periodicity properties of functions that arise in quantum calculus, which has been emerging as an important branch of mathematics due to its various applications in physics and other related fields. The paper has two components. First, a relation between two existing periodicity notions is established. Second, the existence of periodic solutions of a q-Volterra integral equation, which is a general integral form of a first order q-difference equation, is obtained. At the end, some examples are provided. These examples show the effectiveness of the relation between the two periodicity notions that …

Stochastic Models Of Evidence Accumulation In Changing Environments, Alan Veliz-Cuba, Zachary P. Kilpatrick, Krešimir Josić

Mathematics Faculty Publications

Organisms and ecological groups accumulate evidence to make decisions. Classic experiments and theoretical studies have explored this process when the correct choice is fixed during each trial. However, we live in a constantly changing world. What effect does such impermanence have on classical results about decision making? To address this question we use sequential analysis to derive a tractable model of evidence accumulation when the correct option changes in time. Our analysis shows that ideal observers discount prior evidence at a rate determined by the volatility of the environment, and the dynamics of evidence accumulation is governed by the information …

Almost Automorphic Solutions Of Delayed Neutral Dynamic Systems On Hybrid Domains, Murat Adıvar, Halis Can Koyuncuoğlu, Youssef Raffoul

Mathematics Faculty Publications

We study the existence of almost automorphic solutions of the delayed neutral dynamic system on hybrid domains that are additively periodic. We use exponential dichotomy and prove uniqueness of projector of exponential dichotomy to obtain some limit results leading to sufficient conditions for existence of almost automorphic solutions to neutral system. Unlike the existing literature we prove our existence results without assuming boundedness of the coefficient matrices in the system. Hence, we significantly improve the results in the existing literature. Finally, we also provide an existence result for an almost periodic solutions of the system.

Positive Solutions For A Singular Fourth Order Nonlocal Boundary Value Problem, John M. Davis, Paul W. Eloe, John R. Graef, Johnny Henderson

Mathematics Faculty Publications

Positive solutions are obtained for the fourth order nonlocal boundary value problem, u⁽⁴⁾=f(x,u), 0 < x < 1, u(0) = u''(0) = u'(1) = u''(1) - u''(2/3)=0, where f(x,u) is singular at x = 0, x=1, y=0, and may be singular at y=∞. The solutions are shown to exist at fixed points for an operator that is decreasing with respect to a cone.

Necessary And Sufficient Conditions For Stability Of Volterra Integro-Dynamic Equation Systems On Time Scales, Youssef Raffoul

Mathematics Faculty Publications

In this research we establish necessary and sufficient conditions for the stability of the zero solution of scalar Volterra integro-dynamic equation on general time scales. Our approach is based on the construction of suitable Lyapunov functionals. We will compare our findings with known results and provides application to quantum calculus.