Physical Sciences and Mathematics Commons^™

Meta-Analysis Of Lapatinib Plus Capecitabine Versus Capecitabine In The Treatment Of Her2 Positive Breast Cancer, Lynda Smith

Culminating Projects in Applied Statistics

BACKGROUND:

Breast cancer is the most common type of cancer in women despite advances in research and detection methods. Approximately 25 to 30 percent of newly diagnosed cases of breast cancer will overexpress HER2, human epidermal growth factor receptor 2, and are at a greater risk for disease progression and poorer clinical outcomes. The traditional treatment is associated with irreversible cardiac dysfunction. An alternative treatment involving lapatinib plus capecitabine has been reported in some randomized controlled clinical trials comparing treatment outcomes. To quantify the effectiveness of lapatinib plus capecitabine combination therapy versus capecitabine monotherapy in treating metastatic breast cancer, a …

Integrated Bioinformatics, Environmental Epidemiologic And Genomic Approaches To Identify Environmental And Molecular Links Between Endometriosis And Breast Cancer, Deodutta Roy, Marisa L. Morgan, Changwon Yoo, Alok Deoraj, Sandhya Roy, Vijay Kumar Yadav, Mohannad Garoub, Hamza Assaggaf, Mayur Doke

Department of Biostatistics Faculty Publications

We present a combined environmental epidemiologic, genomic, and bioinformatics approach to identify: exposure of environmental chemicals with estrogenic activity; epidemiologic association between endocrine disrupting chemical (EDC) and health effects, such as, breast cancer or endometriosis; and gene-EDC interactions and disease associations. Human exposure measurement and modeling confirmed estrogenic activity of three selected class of environmental chemicals, polychlorinated biphenyls (PCBs), bisphenols (BPs), and phthalates. Meta-analysis showed that PCBs exposure, not Bisphenol A (BPA) and phthalates, increased the summary odds ratio for breast cancer and endometriosis. Bioinformatics analysis of gene-EDC interactions and disease associations identified several hundred genes that were altered by …

Computational Modeling To Study Disease Development: Applications To Breast Cancer And An In Vitro Model Of Macular Degeneration, Qanita Bani Baker

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

There have been several techniques developed in recent years to develop computer models of a variety of disease behaviors. Agent-based modeling is a discrete-based modeling approach used agents to represent individual cells that mechanically interact and secrete, consume or react to soluble products. It has become a powerful modeling approach, widely used by computational researchers. In this research, we utilized agent-based modeling to study and explore disease development, particularly in two applications, breast cancer and bioengineering experiments. We further proposed an error-minimization search approach and used it to estimate cellular parameters from multicellular in vitro data.

In this dissertation, in …

E-Esas: Evolution Of A Participatory Design-Based Solution For Breast Cancer (Bc) Patients In Rural Bangladesh, Mohammad Munirul Haque, Ferdaus Kawsar, Mohammad Adibuzzaman, Md Miftah Uddin, Sheikh Iqbal Ahamed, Richard Love, Ragib Hasan, Rumana Dowla, Tahmina Ferdousy, Reza Salim

Mathematics, Statistics and Computer Science Faculty Research and Publications

Healthcare facility is scarce for rural women in the developing world. The situation is worse for patients who are suffering from diseases that require long-term feedback-oriented monitoring such as breast cancer. Lack of motivation to go to the health centers on patients’ side due to sociocultural barriers, financial restrictions and transportation hazards results in inadequate data for proper assessment. Fortunately, mobile phones have penetrated the masses even in rural communities of the developing countries. In this scenario, a mobile phone-based remote symptom monitoring system (RSMS) with inspirational videos can serve the purpose of both patients and doctors. Here, we present …

Synthesis, Molecular Docking, And Antitumoral Activity Of Alnustone-Like Compounds Against Estrogen Receptor Alpha-Positive Human Breast Cancer, Kaan Küçükoğlu, Hati̇ce Seçi̇nti̇, Aykut Özgür, Hasan Seçen, Yusuf Tutar

Turkish Journal of Chemistry

Alnustone-like compounds are promising inhibitors for estrogen receptor \alpha (ER-\alpha), which is a novel cancer therapeutic target. Therefore, 10 alnustone-like compounds with substituents at the phenyl rings were synthesized by condensation of 4-phenyl-2-butanones and cinnamaldehydes via in situ enamination. The compounds displayed either protective activity or inhibited cell growth and proliferation of human breast cancer cells. Molecular docking studies indicated that the synthesized compounds interact with ER-\alpha efficiently. In this work, the protective and inhibitive roles of the synthesized compounds were related to their functional groups and to their binding mode of action on ER-\alpha protein. The compounds are potential …

The Use Of Textural Kinetic Habitats To Mine Diagnostic Information From Dce Mr Images Of Breast Tumors, Baishali Chaudhury

USF Tampa Graduate Theses and Dissertations

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of the breast is a widely used non-invasive approach to gather information about the underlying physiology of breast tumors. Recent studies indicate that breast tumor heterogeneity may reflect the presence of different levels of cellular aggressiveness or habitats within the tumor. This heterogeneity has been correlated to the variations in the contrast enhancement patterns within the tumor apparent on gadolinium-enhanced DCE-MRI. Although pathological and qualitative (based on contrast enhancement patterns) studies suggest the presence of clini- cal and molecular predictive tumor sub-regions, this has not been fully investigated in the quantitative domain.

The …