Physical Sciences and Mathematics Commons^™

Meta-Analysis Of Type I Error Rates For Detecting Differential Item Functioning With Logistic Regression And Mantel-Haenszel In Monte Carlo Studies, Eva Van De Water Ph. D.

Eva Van De Water

Differential item functioning (DIF) occurs when individuals from different groups who have equal levels of a latent trait fail to earn commensurate scores on a testing instrument. Type I error occurs when DIF-detection methods result in unbiased items being excluded from the test while a Type II error occurs when biased items remain on the test after DIF-detection methods have been employed. Both errors create potential issues of injustice amongst examinees and can result in costly and protracted legal action. The purpose of this research was to evaluate two methods for detecting DIF: logistic regression (LR) and Mantel-Haenszel (MH).

To …

Ligand-Receptor Interactions For Supramolecular Disassembly With Applications In Screening And Drug Delivery, Diego F. Amado Torres

Diego Amado Torres

Proteins have the capacity to bind specific sets of compounds known as ligands, these are small molecules with a recurrent theme in their molecular design that is a characteristic exploited here to (i) identify particular affinities of small molecules for proteins with the aim of using them as ligands, inhibitors, or targeting moieties in more complex systems by means of a methodology that screens small molecules based on protein affinity; (ii) decorate a self-assembling supramolecular system at different positions, making it responsive to a complementary protein with the aim of exploring differences in disassembly and sensitivity of the release of …