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Full-Text Articles in Physical Sciences and Mathematics
Conformational Response To Solvent Interaction And Temperature Of A Protein (Histone H3.1) By A Multi-Grained Monte Carlo Simulation, Ras B. Pandey, Barry L. Farmer
Conformational Response To Solvent Interaction And Temperature Of A Protein (Histone H3.1) By A Multi-Grained Monte Carlo Simulation, Ras B. Pandey, Barry L. Farmer
Faculty Publications
Interaction with the solvent plays a critical role in modulating the structure and dynamics of a protein. Because of the heterogeneity of the interaction strength, it is difficult to identify multi-scale structural response. Using a coarse-grained Monte Carlo approach, we study the structure and dynamics of a protein (H3.1) in effective solvent media. The structural response is examined as a function of the solvent-residue interaction strength (based on hydropathy index) in a range of temperatures (spanning low to high) involving a knowledge-based (Miyazawa-Jernigan(MJ)) residue-residue interaction. The protein relaxes rapidly from an initial random configuration into a quasi-static structure at low …
A Hierarchical Coarse-Grained (All-Atom-To-All-Residue) Computer Simulation Approach: Self-Assembly Of Peptides, Ras B. Pandey, Zhifeng Kuang, Barry L. Farmer
A Hierarchical Coarse-Grained (All-Atom-To-All-Residue) Computer Simulation Approach: Self-Assembly Of Peptides, Ras B. Pandey, Zhifeng Kuang, Barry L. Farmer
Faculty Publications
A hierarchical computational approach (all-atom residue to all-residue peptide) is introduced to study self-organizing structures of peptides as a function of temperature. A simulated residue-residue interaction involving all-atom description, analogous to knowledge-based analysis (with different input), is used as an input to a phenomenological coarse-grained interaction for large scales computer simulations. A set of short peptides P1 (1H 2S 3S 4Y 5W 6Y 7A 8F 9N 10N 11K 12T) is considered as an example to illustrate the utility. We find that peptides assemble rather fast into globular …
Laughing At The Looking Glass: Does Humor Style Serve As An Interpersonal Signal?, Virgil Zeigler-Hill, Avi Besser, Stephanie E. Jett
Laughing At The Looking Glass: Does Humor Style Serve As An Interpersonal Signal?, Virgil Zeigler-Hill, Avi Besser, Stephanie E. Jett
Faculty Publications
Objective: The provision of information appears to be an important feature of humor. The present studies examined whether humor serves as an interpersonal signal such that an individual's style of humor is associated with how the individual is perceived by others. Method: We examined this issue across two studies. In Study 1, undergraduate participants (257 targets) were rated more positively by their friends and family members (1194 perceivers) when they possessed more benign humor styles. In Study 2, 1190 community participants rated the romantic desirability of targets ostensibly possessing different humor styles. Results: Across both studies, our results were consistent …
On The Currents And Transports Connected With The Atlantic Meridional Overturning Circulation In The Subpolar North Atlantic, X. Xu, H. E. Hurlburt, W. J. Schmitz Jr., R. Zantopp, J. Fischer, P.J. Hogan
On The Currents And Transports Connected With The Atlantic Meridional Overturning Circulation In The Subpolar North Atlantic, X. Xu, H. E. Hurlburt, W. J. Schmitz Jr., R. Zantopp, J. Fischer, P.J. Hogan
Faculty Publications
Results from an interannually forced, 0.08 degrees eddy-resolving simulation based on the Hybrid Coordinate Ocean Model, in conjunction with a small but well-determined transport database, are used to investigate the currents and transports associated with the Atlantic meridional overturning circulation (AMOC) in the subpolar North Atlantic (SPNA). The model results yield a consistent warming in the western SPNA since the early 1990s, along with mean transports similar to those observed for the trans-basin AMOC across the World Ocean Circulation Experiment hydrographic section AR19 (16.4 Sv) and boundary currents at the exit of the Labrador Sea near 53 degrees N (39.0 …