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Full-Text Articles in Physical Sciences and Mathematics
Design And Synthesis Of Boronic Acid-Based Sensors For Microarray Analysis And Fret-Detection To Study Carbohydrates, Yilin Wang
Masters Theses
Carbohydrates play significant roles in various biological and pathological processes such as cancer metastasis and inflammation. They participate in various signaling pathways and are able to bind to a litany of biological receptors such as proteins and viruses. Biologists have known for decades that the structure of glycans changes with the onset of cancer and inflammation. Due to these important activities, carbohydrate sensing has long been a focus of research. One example of such a carbohydrate sensor is boronic acid-based sensors. Boronic acid-based sensors are of particular interest due to their selectivity for 1,2- or 1,3-diols. A variety of techniques …
Health Status, Infection And Disease In California Sea Lions (Zalophus Californianus) Studied Using A Canine Microarray Platform And Machine-Learning Approaches, Annalaura Mancia, James C. Ryan, Robert W. Chapman, Qingzhong Wu, Gregory W. Warr, Frances M.D. Gulland, Frances M. Van Dolah
Health Status, Infection And Disease In California Sea Lions (Zalophus Californianus) Studied Using A Canine Microarray Platform And Machine-Learning Approaches, Annalaura Mancia, James C. Ryan, Robert W. Chapman, Qingzhong Wu, Gregory W. Warr, Frances M.D. Gulland, Frances M. Van Dolah
United States Department of Commerce: Staff Publications
Conservation biologists face many challenges in assessing health, immune status and infectious diseases in protected species. These challenges include unpredictable sample populations, diverse genetic and environmental backgrounds of the animals, as well as the practical, legal and ethical issues involved in experimentation. The use of whole genome scale transcriptomics with animal samples obtained in a minimally invasive manner is an approach that shows promise for health assessment. In this study we assessed the utility of a microarray to identify changes in gene expression predictive of health status by interrogating blood samples from California sea lions (Zalophus californianus) in …