Physical Sciences and Mathematics Commons^™

Protective Interactions Of Dairy Peptides With Fibril Structures And Relevance To Alzheimer's Disease, Louise Bennett, Williams Roderick, Heath Ecroyd, Yanqin Liu, Sunanda Sudharmarajan, John Carver

Heath Ecroyd

Selected dairy caseins have been shown to have capacity for chaperone-like regulation of folding pathways of other caseins, specifically in preventing development of fibrillar aggregates of beta sheet structure. An assay based on fibril formation by reduced and carboxymethylated-kappa casein (RCM-kCn) was thus used to screen for anti-fibril activity among a selection of dairy protein hydrolysates, in order to discover peptides with possible anti-fibril, chaperone activity. From the selection of eight dairy hydrolysates based on different dairy protein fractions, two of the hydrolysates of whey protein exhibited superior anti-fibril bioactivity against RCM-kCn and amyloid beta (Aβ), the peptide associated with …

Crop Updates 2011 - Farming Systems, Janette Drew, Rob Grima, Bob French, Raj Malik, Mark Seymour, Christine Zaicou-Kunesch, Glenn Mcdonald, Brendon Nicholas, Dennis Van Gool, James Fisher, Peter Tozer, Doug Abrecht, Michael Robertson, Cameron Weeks, Michael O'Conner, Peter Newman, Mike Clarke, Andrew Blake, Gordon Macaulay, Vijay Jayasena, Syed M. Nasar-Abbas, Larisa Cato, Robert Loughman, Ken Quail

Crop Updates

This session covers twelve papers from different authors:

1. Fallowing 50% of the farm each year – does it pay? Janette Drew and Rob Grima

Department of Agriculture and Food

2. How crop sequences affect the productivity and resilience of cropping systems in two Western Australian environments, Bob French, Raj Malik, Mark Seymour, Department of Agriculture and Food

3. When is continuous wheat or barley sustainable? Christine Zaicou-Kunesch and Rob Grima Department of Agriculture and Food

4. Identifying constraints to bridging the yield gap, Glenn McDonald, Department of Agriculture and Food

5. Land constraints limiting wheat yields in …

Application Of Microsimulation To Disease Transmission And Control, A Green, Y Zhang, I Piper, Daniel Keep

Faculty of Informatics - Papers (Archive)

In this paper, we present an extension of our novel microsimulation technique, as applied to biological infection spread, to estimate the underlying causal parameters driving an infectious process. The underlying simulation framework, Simulacron, was developed in order to understand the development and course of, response to and recovery from single and multiple threats on community populations. Such threats include a range of natural (such as disease spread in communities, fire, flood etc.) and manmade events (such as terrorism, including the use of biological agents, money laundering, smuggling as well as accidents etc.). These threats can cause serious disruption to modern …

Wild Type And Tangier Disease Abca1 Mutants Modulate Cellular Amyloid-Beta Production Independent Of Cholesterol Efflux Activity, Kim S. Woojin, Andrew F. Hill, Michael L. Fitzgerald, Mason W. Freeman, Genevieve Evin, Brett Garner

Faculty of Science - Papers (Archive)

Cerebral amyloid-β (Aβ) deposition is a critical feature of Alzheimer’s disease. Aβ is derived from the amyloid-β protein precursor (AβPP) via two sequential cleavages that are mediated by β-secretase and the γ-secretase complex. Such amyloidogenic AβPP processing occurs in lipid raft microdomains of cell membranes and it is thought that modulating the distribution of lipids in rafts may regulate AβPP processing and Aβ production. Certain ATP-binding cassette (ABC) transporters regulate lipid transport across cell membranes and, as recent studies reveal, within membrane microdomains. ABCA1 also regulates Aβ metabolism in the brain although its direct impact on AβPP remains an open …

Lipid Pathway Alterations In Parkinson's Disease Primary Visual Cortex, Danni Cheng, Andrew M. Jenner, Guanghou Shui, Wei Fun Cheong, Todd W. Mitchell, Jessica Nealon, Woojin Scott Kim, H Mccann, Markus R. Wenk, Glenda Halliday, Brett Garner

Faculty of Science - Papers (Archive)

Background: We present a lipidomics analysis of human Parkinson’s disease tissues. We have focused on the primary visual cortex, a region that is devoid of pathological changes and Lewy bodies; and two additional regions, the amygdala and anterior cingulate cortex which contain Lewy bodies at different disease stages but do not have as severe degeneration as the substantia nigra. Methodology/Principal Findings: Using liquid chromatography mass spectrometry lipidomics techniques for an initial screen of 200 lipid species, significant changes in 79 sphingolipid, glycerophospholipid and cholesterol species were detected in the visual cortex of Parkinson’s disease patients (n = 10) compared to …

Structural Interactions And Dynamics Of Disease Related Proteins By Using Nmr Spectroscopy, Shadakshara Swamy Puttamadappa

Legacy Theses & Dissertations (2009 - 2024)

Nuclear Magnetic Resonance (NMR) is a powerful spectroscopic technique to study the structure, molecular interactions, and dynamics of proteins. Modern NMR instrumentation, advancements in experimental techniques and revolutionary developments in recombinant DNA technology have made NMR a versatile and very convenient tool for biomolecule characterization.