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Genome-Scale Metabolic Analysis Of Clostridium Thermocellum For Bioethanol Production, Seth B. Roberts, Christopher M. Gowen, J. Paul Brooks, Stephen S. Fong
Genome-Scale Metabolic Analysis Of Clostridium Thermocellum For Bioethanol Production, Seth B. Roberts, Christopher M. Gowen, J. Paul Brooks, Stephen S. Fong
Chemical and Life Science Engineering Publications
Background
Microorganisms possess diverse metabolic capabilities that can potentially be leveraged for efficient production of biofuels. Clostridium thermocellum (ATCC 27405) is a thermophilic anaerobe that is both cellulolytic and ethanologenic, meaning that it can directly use the plant sugar, cellulose, and biochemically convert it to ethanol. A major challenge in using microorganisms for chemical production is the need to modify the organism to increase production efficiency. The process of properly engineering an organism is typically arduous.
Results
Here we present a genome-scale model of C. thermocellum metabolism, iSR432, for the purpose of establishing a computational tool to study the …