Physical Sciences and Mathematics Commons^™

Computed Tomography Imaging To Quantify Iodine Distribution In Iododeoxyuridine-Labeled Dna, Christopher Erik Welch

LSU Master's Theses

Purpose: Treatment planning for x-ray activated Auger electron radiotherapy requires knowledge of the spatial distribution of Auger electron-producing target atoms in DNA; iodine is a candidate atom. Because planning uses computed tomography (CT) data to show anatomy, obtaining the target atoms' distribution with CT methods is an attractive goal. This study evaluates the ability of two available CT systems to measure the target atoms' spatial distribution. Method and Materials: A polychromatic desktop CT scanner and a synchrotron monochromatic CT system acquired images of iodine concentrations in water, ranging from 0.03-10 mg/ml. The polychromatic scanner was operated at 40 kVp while …