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Full-Text Articles in Physical Sciences and Mathematics

Statistical Issues In Proteomic Research, Jeffrey S. Morris Dec 2007

Statistical Issues In Proteomic Research, Jeffrey S. Morris

Jeffrey S. Morris

No abstract provided.


Internet Enabled Remote Driving Of A Combat Hybrid Electric Power System For Duty Cycle Measurement, Jarrett Goodell, Marc Compere, Wilford Smith, Mark Brudnak, Mike Pozolo, Et Al. Jun 2007

Internet Enabled Remote Driving Of A Combat Hybrid Electric Power System For Duty Cycle Measurement, Jarrett Goodell, Marc Compere, Wilford Smith, Mark Brudnak, Mike Pozolo, Et Al.

Publications

This paper describes a human-in-the-loop motion-based simulator interfaced to hybrid-electric power system hardware, both of which were used to measure the duty cycle of a combat vehicle in a virtual simulation environment. The project discussed is a greatly expanded follow-on to the experiment published in [1,7]. This paper is written in the context of [1,7] and therefore highlights the enhancements. The most prominent of these enhancements is the integration (in real-time) of the Power & Energy System Integration Lab (P&E SIL) with a motion base simulator by means of a “long haul” connection over the Internet (a geographical distance of …


Laser Capture Sampling And Analytical Issues In Proteomics, Howard Gutstein, Jeffrey S. Morris Jan 2007

Laser Capture Sampling And Analytical Issues In Proteomics, Howard Gutstein, Jeffrey S. Morris

Jeffrey S. Morris

Proteomics holds the promise of evaluating global changes in protein expression and post-translational modificaiton in response to environmental stimuli. However, difficulties in achieving cellular anatomic resolution and extracting specific types of proteins from cells have limited the efficacy of these techniques. Laser capture microdissection has provided a solution to the problem of anatomical resolution in tissues. New extraction methodologies have expanded the range of proteins identified in subsequent analyses. This review will examine the application of laser capture microdissection to proteomic tissue sampling, and subsequent extraction of these samples for differential expression analysis. Statistical and other quantitative issues important for …