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Full-Text Articles in Physical Sciences and Mathematics
Multiwavelength Monitoring Of The Narrow-Line Seyfert 1 Galaxy Arakelian 564. Iii. Optical Observations And The Optical--Uv--X-Ray Connection, O. Shemmer, P. Romano, R. Bertram, W. Brinkmann, S. Collier, K. A. Crowley, E. Detsis, A. V. Filippenko, C. Martin Gaskell, T. A. George, M. Gliozzi, M. E. Hiller, T. L. Jewell, Shai Kaspi, Elizabeth S. Klimek, M. H. Lannon, W D. Li, P. Martini, Smita Mathur, H. Negoro, Hagai Netzer, Iossif Papadakis, Ioannis Papamastorakis, Bradley M. Peterson, Bradley W. Peterson, Richard William Pogge, V. I. Pronik, Kenneth S. Rumstay, S. G. Sergeev, G. M. Stirpe, C. J. Taylor, R. R. Treffers, T. J. Turner, P. Uttley, Marianne Vestergaard, Kaspar Von Braun, R. M. Wagner, Z. Zheng
Multiwavelength Monitoring Of The Narrow-Line Seyfert 1 Galaxy Arakelian 564. Iii. Optical Observations And The Optical--Uv--X-Ray Connection, O. Shemmer, P. Romano, R. Bertram, W. Brinkmann, S. Collier, K. A. Crowley, E. Detsis, A. V. Filippenko, C. Martin Gaskell, T. A. George, M. Gliozzi, M. E. Hiller, T. L. Jewell, Shai Kaspi, Elizabeth S. Klimek, M. H. Lannon, W D. Li, P. Martini, Smita Mathur, H. Negoro, Hagai Netzer, Iossif Papadakis, Ioannis Papamastorakis, Bradley M. Peterson, Bradley W. Peterson, Richard William Pogge, V. I. Pronik, Kenneth S. Rumstay, S. G. Sergeev, G. M. Stirpe, C. J. Taylor, R. R. Treffers, T. J. Turner, P. Uttley, Marianne Vestergaard, Kaspar Von Braun, R. M. Wagner, Z. Zheng
Department of Physics and Astronomy: Faculty Publications
We present the results of a 2 yr long optical monitoring program of the narrow-line Seyfert 1 galaxy Ark 564. The majority of this monitoring project was also covered by X-ray observations (RXT E), and for a period of ~50 days, we observed the galaxy in UV (HST) and X-rays (RXTE and ASCA) simultaneously with the ground-based observations. Rapid and large-amplitude variations seen in the X-ray band, on a daily and hourly timescale, were not detected at optical and UV wavelengths, which in turn exhibited much lower variability either on short (1 day) or long (several months) timescales. The only …
Inhibition Of The Aminopeptidase From Aeromonas Proteolytica By L-Leucinephosphonic Acid. Spectroscopic And Crystallographic Characterization Of The Transition State Of Peptide Hydrolysis, Carin Stamper, Brian Bennett, Tanya Edwards, Richard C. Holz, Dagmar Ringe, Gregory A. Petsko
Inhibition Of The Aminopeptidase From Aeromonas Proteolytica By L-Leucinephosphonic Acid. Spectroscopic And Crystallographic Characterization Of The Transition State Of Peptide Hydrolysis, Carin Stamper, Brian Bennett, Tanya Edwards, Richard C. Holz, Dagmar Ringe, Gregory A. Petsko
Physics Faculty Research and Publications
The nature of the interaction of the transition-state analogue inhibitor l-leucinephosphonic acid (LPA) with the leucine aminopeptidase from Aeromonas proteolytica (AAP) was investigated. LPA was shown to be a competitive inhibitor at pH 8.0 with a Ki of 6.6 μM. Electronic absorption spectra, recorded at pH 7.5 of [CoCo(AAP)], [CoZn(AAP)], and [ZnCo(AAP)] upon addition of LPA suggest that LPA interacts with both metal ions in the dinuclear active site. EPR studies on the Co(II)-substituted forms of AAP revealed that the environments of the Co(II) ions in both [CoZn(AAP)] and [ZnCo(AAP)] become highly asymmetric and constrained upon the addition of …