Physical Sciences and Mathematics Commons^™

Biogenetically Inspired Total Synthesis Of Lingzhiol. Design And Synthesis Of Axially Chiral N-Heterocyclic Carbene Catalysts., Krishna Sharmah Gautam

Arts & Sciences Electronic Theses and Dissertations

A stereo- and enantio-selective synthesis of lingzhiol has been achieved, mimicking a proposed biogenetic pathway via Brønsted acid-catalyzed semipinacol rearrangement of a 2,3-epoxy alcohol. A new and improved method was developed for alkylation of anilines using a domestic microwave oven. The resulting racemic chiral anilines were resolved via classical resolution and transformed into axially chiral thiazolylidene-based NHC organocatalysts, which were applied to asymmetric benzoin condensation.

Indoor Scene Localization To Fight Sex Trafficking In Hotels, Abigail Stylianou

McKelvey School of Engineering Theses & Dissertations

Images are key to fighting sex trafficking. They are: (a) used to advertise for sex services,(b) shared among criminal networks, and (c) connect a person in an image to the place where the image was taken. This work explores the ability to link images to indoor places in order to support the investigation and prosecution of sex trafficking. We propose and develop a framework that includes a database of open-source information available on the Internet, a crowd-sourcing approach to gathering additional images, and explore a variety of matching approaches based both on hand-tuned features such as SIFT and learned features …

A Traders Guide To The Predictive Universe- A Model For Predicting Oil Price Targets And Trading On Them, Jimmie Harold Lenz

Doctor of Business Administration Dissertations

At heart every trader loves volatility; this is where return on investment comes from, this is what drives the proverbial “positive alpha.” As a trader, understanding the probabilities related to the volatility of prices is key, however if you could also predict future prices with reliability the world would be your oyster. To this end, I have achieved three goals with this dissertation, to develop a model to predict future short term prices (direction and magnitude), to effectively test this by generating consistent profits utilizing a trading model developed for this purpose, and to write a paper that anyone with …

Application Of The Dispersive Optical Model To 208pb, Michael Keim

Undergraduate Research Symposium Posters

A review of developments for the application of the dispersive optical model (DOM) to ²⁰⁸Pb is presented. By providing appropriate parameters describing real and imaginary parts of a nonlocal self-energy, connected through a dispersion relation, reasonable reproductions of both scattering and bound-state properties are generated. By fitting these parameters to experimental data, a more accurate description of the neutron skin may be achieved, which would have implications for the physics of neutron stars.

Survival Analysis In A Clinical Setting, Yunzhao Liu

Arts & Sciences Electronic Theses and Dissertations

With the fast paced advancement of modern medicine, cancer treatments have improved greatly over the past few decades; however, the overall survival rate has not improved for head neck squamous cell carcinoma (HNSCC). Traditionally, the general affected population of HNSCC was male over 50-60 years of age, whom have had history of alcohol and tobacco use. Conversely, in the recent decades, HNSCC has exhibited significant rise in younger patients, largely due to the increase in human papillomavirus (HPV) infection among young adults.

Generally, HPV as the most prevalent sexually transmitted disease, consisted of strains that do not cause harm to …

Development Of A Long-Period Torsion Balance For Tests Of Einstein's Equivalence Principle And A Search For Normal Mode Torsional Oscillations Of The Earth, Michael David Abercrombie

Arts & Sciences Electronic Theses and Dissertations

This thesis describes the development of a torsion balance experiment designed to test Einstein's equivalence principle with unprecedented sensitivity, while also taking a novel approach to directly observe the normal mode torsional oscillations of the Earth. Accordingly, a model of the signal expected from a potential equivalence principle violation has been developed, as well as a multi-slit auto-collimating optical lever which possesses a resolution on the order of a nanoradian and a range of observation of 10 milliradians and is used to monitor the torsion balance. A torsion balance with a natural torsional frequency of ~104 Hz, signi_cantly below the …

Nanostructured Thin Film Synthesis By Aerosol Chemical Vapor Deposition For Energy Storage Applications, Tandeep Singh Chadha

McKelvey School of Engineering Theses & Dissertations

Renewable energy sources offer a viable solution to the growing energy demand while mitigating concerns for greenhouse gas emissions and climate change. This has led to a tremendous momentum towards solar and wind-based energy harvesting technologies driving efficiencies higher and costs lower. However, the intermittent nature of these energy sources necessitates energy storage technologies, which remain the Achilles heel in meeting the renewable energy goals. This dissertation focusses on two approaches for addressing the needs of energy storage: first, targeting direct solar to fuel conversion via photoelectrochemical water-splitting and second, improving the performance of current rechargeable batteries by developing new …

Geometric Inference With Microlens Arrays, Ian Schillebeeckx

McKelvey School of Engineering Theses & Dissertations

This dissertation explores an alternative to traditional fiducial markers where geometric

information is inferred from the observed position of 3D points seen in an image. We offer an alternative approach which enables geometric inference based on the relative orientation

of markers in an image. We present markers fabricated from microlenses whose appearance

changes depending on the marker's orientation relative to the camera. First, we show how

to manufacture and calibrate chromo-coding lenticular arrays to create a known relationship

between the observed hue and orientation of the array. Second, we use 2 small chromo-coding lenticular arrays to estimate the pose of …

Calcium Carbonate Formation In Energy-Related Subsurface Environments And Engineered Systems, Qingyun Li

McKelvey School of Engineering Theses & Dissertations

Geologic CO2 sequestration (GCS) in subsurface saline aquifers is a promising strategy to mitigate climate change caused by increasing anthropogenic CO2 emissions from energy production. At GCS sites, interactions between fluids and geomedia are important because they can affect CO2 trapping efficiency and the safety of CO2 storage. These interactions include the dissolution and precipitation of minerals. One of the most important minerals is calcium carbonate, because it can permanently trap CO2.

In this work, Portland cement was used as a model geomedium to investigate the chemical reactions, mechanical alterations, transport of reactive fluids, and the interplay of all these …

Actin-Based Feedback Circuits In Cell Migration And Endocytosis, Xinxin Wang

Arts & Sciences Electronic Theses and Dissertations

In this thesis, we study the switch and pulse functions of actin during two important cellular processes, cell migration and endocytosis. Actin is an abundant protein that can polymerize to form a dendritic network. The actin network can exert force to push or bend the cell membrane. During cell migration, the actin network behaves like a switch, assembling mostly at one end or at the other end. The end with the majority of the actin network is the leading edge, following which the cell can persistently move in the same direction. The other end, with the minority of the actin …

Bayesian Networks To Assess The Newborn Stool Microbiome, William E. Bennett Jr.

McKelvey School of Engineering Theses & Dissertations

In human stool, a large population of bacterial genes and transcripts from hundreds of genera coexist with host genes and transcripts. Assessments of the metagenome and transcriptome are particularly challenging, since there is a great deal of sequence overlap among related species and related genes. We sequenced the total RNA content from stool samples in a neonate using previously-described methods. We then performed stepwise alignment of different populations of RNA sequence reads to different indices, including ribosomal databases, the human genome, and all sequenced bacterial genomes. Each pool of RNA at each alignment step was subjected to compression to assess …

Deep Semantic Image Interpolation, Joshua D. Little

McKelvey School of Engineering Theses & Dissertations

Image datasets often live on a continuum: Images from an outdoor scene vary from day to night, across different weather conditions, and over the course of seasons. Faces age and exhibit different expressions. We consider the problem of taking individual images from these datasets and explicitly manipulating those images to change where they lie on the continuum. We focus on a version of this problem that requires as little input as possible, and we build off of previous work using CNN features to construct an intermediate image manifold on which to manipulate the images. We also investigate a novel way …

Elements Of The Mathematical Formulation Of Quantum Mechanics, Keunjae Go

Senior Honors Papers / Undergraduate Theses

In this paper, we will explore some of the basic elements of the mathematical formulation of quantum mechanics. In the first section, I will list the motivations for introducing a probability model that is quite different from that of the classical probability theory, but still shares quite a few significant commonalities. Later in the paper, I will discuss the quantum probability theory in detail, while paying a brief attention to some of the axioms (by Birkhoff and von Neumann) that illustrate both the commonalities and differences between classical mechanics and quantum mechanics. This paper will end with a presentation of …

Seismic Array Studies Of Antarctica And Madagascar, Martin James Pratt

Arts & Sciences Electronic Theses and Dissertations

The scope of this dissertation is broad, involving seismic array studies from Antarctica and Madagascar, and includes aspects of glaciology and oceanography as well as solid Earth geophysics. Chapter 2 focuses on the study of stickslip motion of the Whillans Ice Stream, West Antarctica. It includes methods combining seismic array and GPS time series, from ice stream based-sensors, to determine source dynamics in the framework of an earthquake source. The source characteristics are then analyzed to explain far-field seismic observations of ice stream- sourced surface waves detected throughout West Antarctica. Locations of asperities, or sticky- spots, that cause the Whillans …

Examining Cost Functionality And Optimization: A Case Study On Testing The Reasonableness Of New Aircraft Using Historical Aircraft Data, Katherine Jozefiak

Arts & Sciences Electronic Theses and Dissertations

When pursuing business by competing for government contracts, proving the submitted price is reasonable is often required. This proof is called a test of reasonableness. This study analyzes data from historical aircraft programs in relation of a new aircraft program in order to demonstrate the estimated cost of the new program is reasonable. The purpose of this study is to investigate three questions. Is the new program cost reasonable using current industry and government parameters? Is it better to look at programs from a total cost perspective or break the total cost into subcategory levels? Finally, this study applies a …

Lead Poisoning In United States Children, Zeren Zhou

Arts & Sciences Electronic Theses and Dissertations

We investigate factors related to blood lead levels of children ages 1 to 5 in the United States for the years 2007-2014. We use data from the National Health and Nutrition Examination Survey (NHANES). The goal is to explore predictors of lead in childrens' blood and to develop a multivariate model using as many predictors as possible. The analysis is conducted using SAS survey regression procedures that account for weighting, stratification, and clustering of the data.

Revelation Of Yin-Yang Balance In Microbial Cell Factories By Data Mining, Flux Modeling, And Metabolic Engineering, Gang Wu

McKelvey School of Engineering Theses & Dissertations

The long-held assumption of never-ending rapid growth in biotechnology and especially in synthetic biology has been recently questioned, due to lack of substantial return of investment. One of the main reasons for failures in synthetic biology and metabolic engineering is the metabolic burdens that result in resource losses. Metabolic burden is defined as the portion of a host cells resources either energy molecules (e.g., NADH, NADPH and ATP) or carbon building blocks (e.g., amino acids) that is used to maintain the engineered components (e.g., pathways). As a result, the effectiveness of synthetic biology tools heavily dependents on cell capability to …

Modeling, Simulation, And Analysis Of Lithium-Ion Batteries For Grid-Scale Applications, Matthew Thomas Lawder

McKelvey School of Engineering Theses & Dissertations

Lithium-ion batteries have become universally present in daily life, being used across a wide range of portable consumer electronics. These batteries are advantageous compared to other forms of energy storage due to their high energy density and long cycle life. These characteristics make lithium-ion batteries advantageous for many new and developing applications that require large scale energy storage such as electric vehicles and the utility grid. Typical uses for lithium-ion batteries require consistent cycling patterns that are predictable and easy to approximate across all uses, but new large scale applications will have much more dynamic demands. The cycling patterns for …

Three Problems In Operator Theory And Complex Analysis, Cheng Chu

Arts & Sciences Electronic Theses and Dissertations

This thesis concerns three distinct problems in operator theory and complex analysis. In Chapter 2, we study the following problem: On the Hardy space H^2, when is the product of a Hankel operator and a Toeplitz operator compact? We give necessary and sucient conditions for when such a product H_fT_g is compact. In Chapter 3, we discuss hyponormal Toeplitz operators. We show that for those operators, there exists a lower bound for the area of the spectrum. This extends the known estimate for the spectral area of Toeplitz operators with an analytic symbol. This part is joint work with Dmitry …

Investigation Of Lung Structure-Function Relationships Using Hyperpolarized Noble Gases, Robert P. Thomen

Arts & Sciences Electronic Theses and Dissertations

Magnetic Resonance Imaging (MRI) is an application of the nuclear magnetic resonance (NMR) phenomenon to non-invasively generate 3D tomographic images. MRI is an emerging modality for the lung, but it suffers from low sensitivity due to inherent low tissue density and short T₂*. Hyperpolarization is a process by which the nuclear contribution to NMR signal is greatly enhanced to more than 100,000 times that of samples in thermal equilibrium. The noble gases ³He and ¹²⁹Xe are most often hyperpolarized by transfer of light angular momentum through the electron of a vaporized alkali metal to the noble …

Classification Trees And Rule-Based Modeling Using The C5.0 Algorithm For Self-Image Across Sex And Race In St. Louis, Rohan Shirali

Arts & Sciences Electronic Theses and Dissertations

The study population comprised children, adolescents, and adults who were residents of the city of St. Louis at the time of data collection in 2015. The data collected includes sex, age, race, measured height and weight, self-reported height and weight, zip code, educational background, exercise and diet habits, and descriptions and strategies of participants' weight (i.e. overweight and trying to lose weight, respectively). I use the C5.0 algorithm to create classification trees and rule-based models to analyze this population. Specifically, I model a binary self-image variable as a function of sex, age, race, zip code, and a ratio of reported …

Genetic Imputation: Accuracy To Application, Shelina Raynell Ramnarine

Arts & Sciences Electronic Theses and Dissertations

Genotype imputation, the process of inferring genotypes for untyped variants, is used to identify and refine genetic association findings. This body of work focuses on assessing imputation accuracy and uses imputed data to identify genetic contributors to mentholated cigarette preference.

Inaccuracies in imputed data can distort the observed association between variants and a disease. Many statistics are used to assess accuracy; some compare imputed to genotyped data and others are calculated without reference to true genotypes. Prior work has shown that the Imputation Quality Score (IQS), which is based on Cohens kappa statistic and compares imputed genotype probabilities to true …

Plate Tectonics Initiation On Earth-Like Planets: Insights From Numerical And Theoretical Analysis Of Convection-Induced Lithospheric Failure, Teresa Wong

Arts & Sciences Electronic Theses and Dissertations

Plate tectonics is central to many aspects of the geology and evolution of terrestrial planets, yet it is only observed on the Earth while all other known planets are covered with a stagnant lithosphere. Plate motions on the Earth are mostly driven by the pull of subducting slabs, therefore understanding the initiation of subduction is crucial to understanding plate tectonics initiation. On a one-plate planet which lacks the forces due to plate motions, some other mechanisms will have to cause the first episode of subduction to mobilize the surface. Sublithospheric convection has been proposed as a possible mechanism that induce …

Seismic Studies Of The Tonga Subduction Zone And The Lau Back-Arc Basin, Songqiao Wei

Arts & Sciences Electronic Theses and Dissertations

This dissertation utilizes multiple techniques of seismic tomography and earthquake location to investigate the upper mantle structure and intermediate-depth seismicity of the Tonga subduction zone, the Lau back-arc basin, and adjacent regions. Data for these studies consist of broadband records from 49 ocean bottom seismographs and 17 island-based seismic stations deployed for one year in 2009-2010, as well as more limited earlier datasets. I conducted tomographic studies of Rayleigh wave velocity and body wave attenuation to examine the thermal variations and the distribution of partial melt in the mantle wedge. The shear-wave velocity structure is first determined using only teleseismic …

Learning With Scalability And Compactness, Wenlin Chen

McKelvey School of Engineering Theses & Dissertations

Artificial Intelligence has been thriving for decades since its birth. Traditional AI features heuristic search and planning, providing good strategy for tasks that are inherently search-based problems, such as games and GPS searching. In the meantime, machine learning, arguably the hottest subfield of AI, embraces data-driven methodology with great success in a wide range of applications such as computer vision and speech recognition. As a new trend, the applications of both learning and search have shifted toward mobile and embedded devices which entails not only scalability but also compactness of the models. Under this general paradigm, we propose a series …

Distributed Target Tracking And Synchronization In Wireless Sensor Networks, Jichuan Li

McKelvey School of Engineering Theses & Dissertations

Wireless sensor networks provide useful information for various applications but pose challenges in scalable information processing and network maintenance. This dissertation focuses on statistical methods for distributed information fusion and sensor synchronization for target tracking in wireless sensor networks.

We perform target tracking using particle filtering. For scalability, we extend centralized particle filtering to distributed particle filtering via distributed fusion of local estimates provided by individual sensors. We derive a distributed fusion rule from Bayes' theorem and implement it via average consensus. We approximate each local estimate as a Gaussian mixture and develop a sampling-based approach to the nonlinear fusion …

Exploiting The Weak Generational Hypothesis For Write Reduction And Object Recycling, Jonathan Andrew Shidal

McKelvey School of Engineering Theses & Dissertations

Programming languages with automatic memory management are continuing to grow in popularity due to ease of programming. However, these languages tend to allocate objects excessively, leading to inefficient use of memory and large garbage collection and allocation overheads.

The weak generational hypothesis notes that objects tend to die young in languages with automatic dynamic memory management. Much work has been done to optimize allocation and garbage collection algorithms based on this observation. Previous work has largely focused on developing efficient software algorithms for allocation and collection. However, much less work has studied architectural solutions. In this work, we propose and …

Environmental Fullerene Chemistry: Elucidating Critical Reaction Pathways And Resulting Products In The Aqueous Phase, Jiewei Wu

McKelvey School of Engineering Theses & Dissertations

As the production of fullerenes and fullerene-based materials approaches industrial scale, there are increasing interests/concerns regarding their (potential) environmental impact(s) upon release. To date, a number of critical, aqueous-based fullerene transformation pathways under environmentally relevant conditions remain poorly understood. Comprehensive, fundamental, and quantitative understanding of the potential (major) reaction pathways and resulting products of fullerene materials, particularly in aquatic systems, is now crucial for their accurate fate, transport, life cycle, risk assessment(s), and thus ultimate material sustainability.

Herein, this dissertation is focused on identifying and elucidating aqueous transformation pathways of fullerene materials, focused on C60 as a model fullerene, under …

Theory Of Carrier Transport From First Principles: Applications In Photovoltaic And Thermoelectric Materials, Alireza Faghaninia

McKelvey School of Engineering Theses & Dissertations

New sources of energy that are environmentally friendly, cost-effective, and renewable are essential if we are to combat the effects of global climate change. Two of these sources are solar photovoltaic (PV) cells to convert sunlight into electricity and thermoelectric (TE) devices to convert heat to electricity. To be practical on a large scale, the properties (e.g. electrical conductivity, band gap, Seebeck coefficient, etc) of the the underlying materials must be improved significantly through judicious control of structure and composition. Significant understanding of materials properties is required to design and engineer new high-performing materials. First principles calculations using density functional …

Goggle Augmented Imaging And Navigation System For Fluorescence-Guided Surgery, Suman Bikash Mondal

McKelvey School of Engineering Theses & Dissertations

Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor resection that necessitates repeat surgery. Sentinel lymph node biopsy by conventional radioactive tracking exposes patients and caregivers to ionizing radiation, while blue dye tracking stains the tissue highlighting only superficial lymph nodes. Improper identification of sentinel lymph nodes may misdiagnose the stage of the cancer. Therefore there is a clinical need for accurate intraoperative tumor and …