Physical Sciences and Mathematics Commons^™

Studies Directed Toward The Enantioselective Addition Of Reformatsky Reagents To Aldimines, Lamyaa Hassib

Honors Theses

Interest in β-amino esters and β-lactams has grown significantly due to their applications in the synthesis of compounds of pharmaceutical interest. Examples include β-lactam antibiotics such as the penicillin and carbapenem families. Because β-lactams and β-amino esters share a common pathway, methods to prepare either are often contaminated and thus complicated by the formation of the other. We have developed convenient and highly controllable method which can afford either product cleanly.

Dinetic And Mechanistic Investigations Of Photocatalysis : Photoreactions Of Cr(Co)6 With Alkenes, Aaron E. Dietrich

Honors Theses

Flash photolysis has proven to be an effective technique for determining reaction mechanisms. Upon photolysis, a CO ligand is removed from Cr(CO)6 forming the reactive molecular fragment Cr(C0)5. In the presence of alkene, L, Cr(CO)s can react to form the meta-stable intermediate Cr(C0)5L. At high L concentrations, Cr(CO)5L decays by pseudo-first-order kinetics with an observed rate constant, kobs, which is dependent on the concentration of both L and added CO. The exar.t nature of the dependence provides insight into the mechanism of the decay of Cr(C0)5L and a plot of 1/kobs vs. [L] will give the rate constants for both …

Studies Directed Toward The Enantioselective Addition Of Reformatsky Reagents To Aldimines, Lamyaa Hassib

Honors Theses

Interest in β-amino esters and β-lactams has grown significantly due to their applications in the synthesis of compounds of pharmaceutical interest. Examples include β-lactam antibiotics such as the penicillin and carbapenem families. Because β-lactams and β-amino esters share a common pathway, methods to prepare either are often contaminated and thus complicated by the formation of the other. We have developed convenient and highly controllable method which can afford either product cleanly.

The Two-Dimensional Ising Model: Mean-Field And Monte Carlo Results For Equilibrium And Nonequilibrium Transitions, Kevin Scott Brown

Honors Theses

No abstract provided.

Exact Real Computational Arithmetic Via Infinite Composition Of Mobiüs Transformations As Presented By Dr. Peter John Potts, Et Al., David Michael Robertson

Honors Theses

No abstract provided.

Molecular Design And Association Constants Of Nizatidine-Guest Complexes, Elizabeth Corbeil

Honors Theses

Nizatidine, N-[2-[[[2-[(dimethylamino)metbyl]-4-thiazolyl]methyl]thio]ethyl]-N'methyl- 2-nitro-l,l-ethenediamine (Axid"), has been investigated for its potential to act as a host in guest-host complexes. Nizatidine binds with the guests through hydrogen bonding and pi-pi interactions. Guest-host studies were conducted using fluorescence quenching, calorimetry, NMR and invisible experiments. The lowest energy conformation of nizatidine is found to be U-shaped through theoretical calculations. Fluorescence experiments indicated that tryptophan and pyridoxine had large association constants. Further studies using calorimetry and NMR techniques concluded that no complexation had occurred. Complexation experiments have been done to find guests that complex with nizatidine. Caffeine, luminol, nicotinamide, phenylalanine, pyridoxine, pyrogallol, and tryptophan were …

Accounting For Sample Selection Bias In Louisiana Hmo Satisfaction Studies, Travis Warziniack

Honors Theses

No abstract provided.

The Dirichlet Problem And Its Physical Motivations, Andrew E. Pitts

Honors Theses

In this work, we explore the basics of harmonic function theory and its relationship to problems in the theory of heat diffusion. In particular, we will focus on the classical Dirichlet problem.

A Method For The Determination Of Purity Of Pnu-10483 Bulk Drug By Capillary Zone Electrophoresis, Gavin Gibson

Honors Theses

In this investigation, a method was developed for the determination of purity of the drug PNU-10483 using the technique of capillary zone electrophoresis (CZE). CZE was seen as a potential alternative to the formerly used procedure of ion-pair reversed phase highperformance liquid chromatography (HPLC). Nearly five years earlier, a similar study was performed, in which an attempt was made to develop a method that used CZE to determine the purity of bulk drug and the potency of drug tablets. While this development was mostly successful, sporadically unpredictable results reduced the method's overall viability. These outliers were thought to be caused …

Problems In Harmonic Function Theory, Ronald A. Walker

Honors Theses

Harmonic Function Theory is a field of differential mathematics that has both many theoretical constructs and physical connections, as well as its store of classical problems.

One such problem is the Dirichlet Problem. While the proof of the existence of a solution is well-founded on basic theory, and general methods for polynomial solutions have been well studied, much ground is still yet to be overturned. In this paper we focus on the examination, properties and computation methods and limitations, of solutions for rational boundary functions.

Another area that we shall study is the properties and generalizations of the zero sets …

Alternatives To Nitroprusside, William T. Hiscock

Honors Theses

Any transition metal nitrosyl complex may release nitric oxide and thus has potential as a vasodilator. Nitroprusside, Na2[Fe(CN)5(NO)], is currently used, but dosages are limited because of the potential release of cyanide. Research in our group has been directed towards the synthesis of iron and ruthenium complexes containing the nitrosyl ligand and polypyridyl coligands such as 2,2-dipyridyl (bpy) and 2,2': 6',2"-terpyridine (tpy). These coligands are much less toxic than cyanide. Both [(bpy)(tpy)Fe(NO)]3+ and [(bpy)(tpy)Ru(NO)]3+ have been synthesized and characterized using infrared and ultraviolet spectroscopy, conductivity, and magnetic susceptibility. Along with the search for other possible polydentate coligands, is the search …

Approaches And Methodologies For The Synthesis Of Aromatic Natural Products, Christina A. Goudreau

Honors Theses

Chemists have been captivated by the ability of most natural products to exhibit biological activity which in effect has made them very attractive to pharmaceutical companies. Many over-the-counter drugs such as aspirin were first extracted from natural products and are now an integral part of most of our lives. More importantly, certain drugs such as taxol, which is used to treat breast cancer, initially came from the bark of a yew tree. Extracting these substances from their natural source and using them medicinally at the demand of the consumers would result in the destruction of the natural habitat. Oftentimes, the …