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Full-Text Articles in Physical Sciences and Mathematics
Metamorphic Epiphany -- 3d Animation, Michael G. Corr
Metamorphic Epiphany -- 3d Animation, Michael G. Corr
Senior Scholar Papers
As far back as I can remember, I have always been interested in studio art. Whether it be painting, drawing, printmaking, or photography, it has consistently been a part of my life. Upon enrolling in Colby, I became interested in computers and decided to major my undergraduate college career in Computer Science. Not forgetting past interests, I continued my studio art education, taking several classes within the Art department. In due time, I began combining interests and began studying Computer Graphics and Design. With limited resources in this field at Colby, the majority of my computer graphic education and experience …
Molecular Design And Association Constants Of Nizatidine-Guest Complexes, Elizabeth Corbeil
Molecular Design And Association Constants Of Nizatidine-Guest Complexes, Elizabeth Corbeil
Honors Theses
Nizatidine, N-[2-[[[2-[(dimethylamino)metbyl]-4-thiazolyl]methyl]thio]ethyl]-N'methyl- 2-nitro-l,l-ethenediamine (Axid"), has been investigated for its potential to act as a host in guest-host complexes. Nizatidine binds with the guests through hydrogen bonding and pi-pi interactions. Guest-host studies were conducted using fluorescence quenching, calorimetry, NMR and invisible experiments. The lowest energy conformation of nizatidine is found to be U-shaped through theoretical calculations. Fluorescence experiments indicated that tryptophan and pyridoxine had large association constants. Further studies using calorimetry and NMR techniques concluded that no complexation had occurred. Complexation experiments have been done to find guests that complex with nizatidine. Caffeine, luminol, nicotinamide, phenylalanine, pyridoxine, pyrogallol, and tryptophan were …
Alternatives To Nitroprusside, William T. Hiscock
Alternatives To Nitroprusside, William T. Hiscock
Honors Theses
Any transition metal nitrosyl complex may release nitric oxide and thus has potential as a vasodilator. Nitroprusside, Na2[Fe(CN)5(NO)], is currently used, but dosages are limited because of the potential release of cyanide. Research in our group has been directed towards the synthesis of iron and ruthenium complexes containing the nitrosyl ligand and polypyridyl coligands such as 2,2-dipyridyl (bpy) and 2,2': 6',2"-terpyridine (tpy). These coligands are much less toxic than cyanide. Both [(bpy)(tpy)Fe(NO)]3+ and [(bpy)(tpy)Ru(NO)]3+ have been synthesized and characterized using infrared and ultraviolet spectroscopy, conductivity, and magnetic susceptibility. Along with the search for other possible polydentate coligands, is the search …
Approaches And Methodologies For The Synthesis Of Aromatic Natural Products, Christina A. Goudreau
Approaches And Methodologies For The Synthesis Of Aromatic Natural Products, Christina A. Goudreau
Honors Theses
Chemists have been captivated by the ability of most natural products to exhibit biological activity which in effect has made them very attractive to pharmaceutical companies. Many over-the-counter drugs such as aspirin were first extracted from natural products and are now an integral part of most of our lives. More importantly, certain drugs such as taxol, which is used to treat breast cancer, initially came from the bark of a yew tree. Extracting these substances from their natural source and using them medicinally at the demand of the consumers would result in the destruction of the natural habitat. Oftentimes, the …