Physical Sciences and Mathematics Commons^™

The Synthesis And Evaluation Of The Cardiovascular Activity Of Novel Imidazole Ring Systems, Joseph E. De Los Angeles

Chemistry & Biochemistry Theses & Dissertations

An investigation was undertaken to synthesize and evaluate the cardiovascular activity of two imidazole ring systems. Imidazoles with hypotensive activity would provide novel potential antihypertensive drugs. These novel structures may also find use as chemical probes in the study of the cardiovascular system and as prototypes for other potential cardiovascular agents.

The histamine derivative, 7,7-dipyridyl-4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine (ligand l), was demonstrated to possess significant hypotensive activity in laboratory rats. A 15 mg/Kg dose of ligand 1 produces a statistically significant decrease in blood pressure when injected IP. This hypotensive effect is also associated with marked increase in heart rate. Although compound 1 …

Deconvolution Techniques With Applications In Cardiovascular Systems Analysis, Lakshminarayan Rajaram

Theses

System characterization by means of Impulse and Frequency Response Functions are well known in classical linear systems analysis. Impulse Response Function is a time domain description of a linear system where as the Frequency Response Function represents the frequency domain counterpart. Linear systems are often characterized in frequency domain. In many biological research applications, it becomes necessary to examine the impulse response function in order to understand the behavior of the system under investigation. One such application is the arterial system in cardiovascular dynamics. It has been shown that although both representations are identical, some aspects of the arterial system …