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Full-Text Articles in Physical Sciences and Mathematics
Automated Reductions Of Markov Chain Models Of Calcium Release Site Models, Yan Hao
Automated Reductions Of Markov Chain Models Of Calcium Release Site Models, Yan Hao
Dissertations, Theses, and Masters Projects
Markov chain models have played an important role in understanding the relationship between single channel gating of intracellular calcium (Ca2+) channels, specifically 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), and the stochastic dynamics of Ca2+ release events, known as Ca2+ puffs and sparks. Mechanistic Ca2+ release site models are defined by the composition of single channel models whose transition probabilities depend on the local calcium concentration and thus the state of the other channels. Unfortunately, the large state space of such compositional models impedes simulation and computational analysis of the whole cell Ca2+ signaling in which the stochastic dynamics of …
Thermochemistry Of Amino Acids And Constrained Diamines, Erica Jane Tullo
Thermochemistry Of Amino Acids And Constrained Diamines, Erica Jane Tullo
Dissertations, Theses, and Masters Projects
The gas-phase proton affinities of several highly basic amino acids and diamines were determined using the extended kinetic method in an ESI-quadrupole ion trap instrument. The non-protein amino acid L-canavanine is structurally related to L-arginine with an oxygen substituted for the terminal methylene group of L-arginine and is highly toxic to humans. The proton affinity of L-arginine, a protein amino acid, was determined to be 1036 kJ mol -1, whereas the proton affinity of L-canavanine was determined to be 1005 kJ mol-1. Thus, substitution of an oxyguanidino group for the guanidine group in L-arginine results in a large decrease in …