Physical Sciences and Mathematics Commons^™

Design Of Novel Anticancer Drugs Utilizing Busulfan For Optimizing Pharmacological Properties And Pattern Recognition Techniques For Elucidation Of Clinical Efficacy, Ronald Bartzatt

Chemistry Faculty Publications

Chronic myelogenous leukemia (CML) is a disorder in which an excessive number of blood stem cells develop into the white blood cell group called granulocytes. The anticancer drug Busulfan is a cell cycle non-specific alkylating agent which is utilized to maintain white blood cell counts below 15000 cells/microliter. The side effects induced by busulfan are significant and affirms the intimation for new drug constructs. Fifteen analogous compounds were generated from the molecular structure of busulfan . These compounds retain the double methanesulfonate functional groups descriptive of this class of alkylating anticancer drugs. However, the carbon chain substituent separating the methanesulfonate …